Clinical significance of the interleukin 8 and interleukin receptor 1 axis in stomach neoplasms

• DOI: 10.3760/cma.j.issn.0254-9026.2018.04.017
• Publication Date: 2018-04-14
• Authors: Liang Yu; Guoqiang Zhou; Shengyuan Yu; Jian Guo; Dechun Li
• Keywords: Neoplasm; Clinical Significance

Objective To explore sensitive indicators for the initiation, development, and metastasis of gastric cancer to provide objective evidence early diagnosis, treatment, progression monitoring cancer.

Methods A total 108 patients with were enrolled in this study.The expression interleukin receptor 1(CXCR1)in samples from adjacent tissues was detected by immunohistochemistry patient clinical data collected correlation analysis.Logistic regression analysis 5-year survival rate conducted.

Results The positive CXCR1 neoplasm significantly higher than that tissues.Nevertheless, correlated tumor differentiation (P=0.017), TNM staging (P=0.006), existence lymphatic (P=0.035). The overall (P=0.043) recurrence-free (P=0.029) lower those negative CXCR1.

Conclusions CXCR1 levels increase are associated differentiation, staging, metastasis.Positive is poor prognosis has potential serve as one prognostic indicators.

Key words: Gastric cancer; CXCL8/CXCR1; Tumor