BackgroundYi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that used to treat patients with liver failure. However, scientific evidence supporting the treatment of hepatic fibrosis YQJPF has not been forthcoming. The present study aimed determine mechanisms underlying anti-fibrotic effects in mouse models fibrosis.MethodsMice were randomly assigned control, model, silymarin (positive treated), and low-, medium- high-dose (7.5, 15, 30 g/kg, respectively) groups. Liver function, inflammatory...

BACKGROUND Hem-o-lock clip, a versatile and reliable non-absorbable tissue has gained widespread acceptance in laparoscopic surgeries for vessel ligation approximation. Its efficacy safety have been well-documented. CASE SUMMARY This case report describes the occurrence of bronchopleural fistula following application clip treatment lobar bronchial stump after lobectomy. CONCLUSION underscores importance exercising caution when using management non-vascular tissues during thoracic surgery.

The details regarding the pathogenesis of hypoxemia in presence acute type-A aortic dissection (ATAAD) remains to be fully elucidated. In this study, we investigated dynamic changes systemic inflammatory response, gut injury, hypoxemia, and succinate levels patients with ATAAD their impact on perioperative hypoxemia. We conducted a single-center, observational, case-control study that enrolled 18 who underwent emergency total arch repair (TAR) combined frozen elephant trunk (FET) procedure...

Ribonucleotide reductase M2 (RRM2) is a rate-limiting enzyme involved in DNA repair and synthesis. This study aimed to investigate the expression level, clinicopathological significance, prognostic value of RRM2 oral squamous cell carcinoma (OSCC).Human OSCC tissue microarrays were used detect RRM2, cancer stem (CSC) markers CD44 aldehyde dehydrogenase 1 (ALDH1), epithelial-mesenchymal transition (EMT) marker Slug. The correlation with parameters was evaluated. effects on proliferation,...

To enhance the thermal performance of shell-tube phase change storage equipment, transient two-dimensional mathematical models RT35 melting were established. The evolution temperature and velocity distribution effect positions inner tube on intensity natural convection for times analyzed. results showed that process liquid fraction could be divided into two stages: stage conduction stage. In stage, due to buoyancy effect, with high-temperature flowed upward convectively heat transferred...

Highly crystalline nano-MFI zeolites with different elemental compositions (Si, Ti, and Al) were synthesized. The effects of composition on the sorption properties toluene acetone clarified.

To fully exploit pore engineering in the design of more efficient zeolite adsorbents for volatile organic compound (VOC) treatment, roles meso- and micropores need to be clarified provide theoretical basis feasible measures. In this work, three VOC sorption properties conventional hierarchical porous beta zeolites were comparatively investigated study micropores. There is a division functions between micro- mesopores, with being main adsorption sites mesopores greatly enhancing diffusion...

<b><i>Background:</i></b> Allergen immunotherapy (AIT) is the unique causal treatment for respiratory allergy. As AIT expensive and of long duration, availability a marker predicting responders crucial relevance. <b><i>Objective:</i></b> To investigate clinical parameters correlated with effective in allergic rhinitis (AR) patients. <b><i>Methods:</i></b> This prospective, nonrandomized open study which total 284 AR...

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles has been developed by reacting hydrazonoyl halides with β-oxophosphonates under mild conditions in good yields excellent regioselectivity. This process employs an addition–elimination sequence. Wide scope, functional group compatibility established.

Purpose:The incidence of allergen specific immunotherapy-related systemic reactions (SRs) varies among different studies, and many factors are likely to contribute SRs.This study aims investigate the incidence, characteristics, risk SRs standardize dust mite-specific subcutaneous immunotherapy (SCIT) in Central China.Methods: All patients receiving standardized mites (100-100,000 SQ-U/mL; Alutard SQ, Hørsholn, Denmark) were followed up.Recorded data included demographics, diagnosis, patient...

Sijunzi decoction (SJZT), a traditional Chinese formula (TCMF) consisting of four herbs, has been widely used for the treatment various gastrointestinal symptoms. However, its modernization process is hindered by lack powerful quality control method that covers major active components in formula. The aim this study was to establish UPLC quantitative determination ten including ginsenoside Rg1, Re, Rb1, liquiritin, liquiritigenin, glycyrrhizic acid, atractylenolide I, II, III, and pachymic...

In this article, the qualitative theoretical derivation, together with finite element analysis and experimental studies are presented to investigate unbalanced magnetic pull (UMP) as well rotor vibration characteristics. Differently from previous studies, study focuses on UMP/vibration not only under normal conventional radial eccentricity conditions but also for three‐dimensional (3D) hybrid static air‐gap (SAGE) cases which composed of both SAGE axial SAGE. The detailed UMP expressions...

Globally, rhinitis is one of the most common chronic disorders. Despite availability drugs to manage symptomatology rhinitis, researchers still focus on identification novel molecular targets for better management. MicroRNAs are implicated in many biological and pathological processes. However, role miR-17-5p remains unexplored. This study aimed explore lipopolysaccharide (LPS)-induced injury nasal epithelial RPMI2650 cells elucidate possible underlying mechanism.LPS damaged by inhibiting...

Abstract Background Allergen immunotherapy (AIT) is the only causal therapy for IgE-mediated allergy. There less evidence about safety and efficacy of AIT especially subcutaneous (SCIT) in children under 5 years old. We aimed to investigate side effects associated risk factors house dust mite (HDM) SCIT preschool with respiratory allergic diseases. Methods The who had HDM-related rhinitis with/without asthma were enrolled undergone standardized HDM our department from June 2013 December...

This study investigated the clinical epidemiological characteristics of nitrous oxide (N2 O) abusers in a hospital China, which have not been systematically reported.The patients abusing N2 O who were examined and treated at Affiliated Hospital Xuzhou Medical University from January 2017 to December 2020 analyzed.A total 61 (average age: 21.7 ± 3.2 years; 42 male 19 female) enrolled; 60.7% had an education level high school or lower, most (59.0%) no stable occupation. The mean exposure time...