SA/GMs/Dex-HA hydrogel provides a potential way for infected burn treatment with high-quality and efficient scar inhibition.

Burn infection is a serious problem that delays wound healing and leads to death. Curcumin (Cur) has been shown exhibit antioxidant, anti-inflammatory, antimicrobial anticarcinogenic activity. However, its instability, extremely low aqueous solubility bioavailability in physiological fluids may make it difficult maintain local Cur concentrations above the minimum inhibitory concentration for burn treatment. The objective of this study was construct complexes Cur/gelatin microspheres (GMs)...

As a representative agent of bicyclic antidepressants, venlafaxine (VEN) has become widely used worldwide and is frequently detected in surface waters with concentrations ranging from ng/L to µg/L. To evaluate the toxicological effects such medications on aquatic species, studies environmentally relevant are essential. Zebrafish were as model organism assess growth development larvae examine tissue accumulation, oxidative stress, DNA methylation adults. The results showed adverse effects,...

Abstract Collagen films have been widely used in the field of biomedical engineering. However, poor mechanical properties collagen limited its application. Here, rod‐like cellulose nanocrystals (CNCs) were fabricated and to reinforce films. A series collagen/CNCs prepared by solution with CNCs suspensions homogeneously dispersed at CNCs: weight ratios 1, 3, 5, 7, 10. The morphology resulting was analyzed scanning electron microscopy (SEM), enhancement thermomechanical composites demonstrated...

Two important issues in skin tissue engineering are the vascularization and regeneration of dermis. Basic fibroblast growth factor (bFGF) is known to promote angiogenesis accelerate wound healing. Direct delivery bFGF area, however, would lead a loss bioactivity. To this end, bFGF-loaded alginate microspheres (Ms) were fabricated incorporated into carboxymethyl chitosan (CMCS)–poly(vinyl alcohol) (PVA) form composite hydrogel. Scanning electron microscopy (SEM) results indicated that...

Tissue-engineered dermis is thought to be the best treatment for skin defects; however, slow vascularization of these biomaterial scaffolds limits their clinical application. Exogenous administration angiogenic growth factors highly desirable tissue regeneration. In this study, biodegradable gelatin microspheres (GMs) containing basic fibroblast factor (bFGF) were fabricated and incorporated into a porous collagen/cellulose nanocrystals (CNCs) scaffold, as platform long-term release...

Diabetic foot ulcers (DFU), which may lead to lower extremity amputation, is one of the severe and chronic complications diabetic mellitus. This study aims develop, use dressings based on Silk fibroin (SF) as scaffold material, gelatin microspheres (GMs) carrier for neurotensin (NT), a neuropeptide that acts an inflammatory modulator in wound healing NT accelerate drug treat DFU. We evaluated processes neo-tissue formation rat model by macroscopic observation, histological observation (H&E...

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) enhance water solubility and biocompatibility. Hyaluronan (HA), as the target ligand for CD44, was bound CHI layer selectively kill cancer cells. To achieve a new treatment strategy cancer, loaded anticancer doxorubicin hydrochloride (DOX). The data showed that DOX zeta potentials of 8.52 ± 0.12 mV at pH 7.4 12.53 0.23 5.5 had high drug-loading...

Diabetic foot ulcers (DFUs) are a threat to human health and can lead amputation even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found be beneficial for diabetic healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility facilitate fibroblast adhesion, spreading proliferation. PLGA/CNC novel materials that have not been used previously as NT carriers...

Evidence indicates that microRNAs (miRNAs) play vital roles in regulating osteogenic differentiation and bone formation. Methods: Here, we show a polyethyleneimine (PEI)-functionalized graphene oxide (GO) complex efficiently loaded with the miR-214 inhibitor is assembled into silk fibroin/hydroxyapatite (SF/HAP) scaffolds spatially control release of inhibitor. Results: SF/HAP/GO nanosized GO high mechanical strength, their hierarchical microporous structures promote cell adhesion growth....

In this study, poly(l-lactide) (PLLA)/halloysite nanotube (HNT) electrospun mats were prepared as a dual-drug delivery system. HNTs used to encapsulate polymyxin B sulphate (a hydrophilic drug). Dexamethasone hydrophobic drug) was directly dissolved in the PLLA solution. The drug-loaded with optimised encapsulation efficiency then mixed solution for subsequent electrospinning form composite dual-drug-loaded fibre mats. structure, morphology, degradability and mechanical properties of...

Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role treating of pathologic remodeling. However, the intrinsically poor solubility and bioavailability hindered clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating (tanshinone IIA-NPs) study efficacy...

Numerous tissue-engineered constructs have been investigated as bone scaffolds in regenerative medicine. However, it remains challenging to non-invasively monitor the biodegradation and remodeling of grafts after implantation. Herein, silk fibroin/hydroxyapatite incorporated with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles were successfully synthesized, characterized, implanted subcutaneously into back nude mice. The USPIO labeled showed good three-dimensional porous...

A type of antibacterial silk fibroin (SF) scaffold was developed and characterised as a potential functional wound dressing for acute trauma treatment. To achieve this, SF solution mixed with previously fabricated vancomycin (Vm)-loaded gelatin (G) microspheres, followed by freeze-drying step. Some physical antimicrobial properties the prepared Vm/G/SF scaffolds were investigated results demonstrated that average pore size porosity composite 60-80 μm 75%, respectively. The compressive stress...

The objective of this study was to develop heparin-conjugated strontium-substituted hydroxyapatite/silk fibroin (Sr-nHAp/SF-Hep) scaffold loaded bone morphogenetic proteins-2 (BMP-2) with sustained release improve regeneration. average pore diameters and porosity Sr-nHAp/SF scaffolds were respectively approximately 150 μm 90%. mechanical properties thermostability the significantly stronger than those SF scaffold. weight composite is higher that in simulated body fluids. exhibited excellent...

Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, inadequate colon adhesion of hinder its clinical application. Based on deficiencies emodin, we prepared monomethoxy-poly (ethylene glycol)-poly (lactic acid)-chitosan-2-mercaptobenzimidazole nanoparticles with incorporated (emodin-NP) studied their efficacy in delaying 5/6 nephrectomized Male Sprague Dawley rats were...