A5002924837- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Sirtuins and Resveratrol in Medicine
- Metabolism, Diabetes, and Cancer
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Connective tissue disorders research
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2023
Wenzhou Medical University
2022-2023
Acute myocardial infarction (MI) triggers oxidative stress, which worsen cardiac function, eventually leads to remodeling and heart failure. Unfortunately, effective therapeutic approaches are lacking. Fibroblast growth factor 7 (FGF7) is proved with respect its proliferative effects high expression level during embryonic development. However, the regulatory role of FGF7 in cardiovascular disease, especially MI, remains unclear. was significantly decreased a mouse model at days after MI....
Fibroblast growth factor-18 (FGF18) has diverse organ development and damage repair roles. However, its role in cardiac homeostasis following hypertrophic stimulation remains unknown. Here we investigate the regulation function of FGF18 pressure overload (PO)-induced pathological hypertrophy. heterozygous (Fgf18+/-) inducible cardiomyocyte-specific knockout (Fgf18-CKO) male mice exposed to transverse aortic constriction (TAC) demonstrate exacerbated hypertrophy with increased oxidative...
Cardiac hypertrophy occurs initially in response to an increased cardiac load as a compensatory mechanism maintain output. However, sustained pathological can develop into heart failure and cause sudden death. Fibroblast growth factor 20 (FGF20) is member of the fibroblast family, which involved apoptosis, aging, inflammation, autophagy. The precise function FGF20 unclear. In this study, we demonstrated that was significantly decreased hypertrophic stimulation. contrast, overexpression...
Myocardial infarction (MI) commonly occurs in patients with coronary artery disease and have high mortality. Current clinical strategies for MI still limited to reducing the death of myocardial cells but failed replace these cells. This study aimed investigate role fibroblast growth factor 6 (FGF6) enhancing proliferative potential cardiomyocytes (CMs) after ischemic injury via Hippo pathway.Expression FGF6 protein was analysed mice induced by ligation left anterior descending artery....
Studies of diabetic glomerular injury have raised the possibility developing useful early biomarkers and therapeutic approaches for treatment type 2 nephropathy (T2DN). In this study, we found that FGF13 expression is induced in endothelial cells (GECs) during T2DN progression. Endothelial-specific deletion Fgf13 potentially alleviates damage, while overexpression has opposite effect. Mechanistically, deficiency results improved mitochondrial homeostasis barrier integrity T2DN. Moreover,...
Abstract myocardial ischemia/reperfusion injury (MIRI) is a common clinic scenario that occurs in the context of reperfusion therapy for acute infarction. Recent studies indicated impaired autophagic flux contributes to MIRI-induced cardiomyocytes (CMs) apoptosis. Fibroblast growth factor 10 (FGF10), multifunctional FGF family member, was reported exert protective effect against renal and hepatic injury. Whether FGF10 has similar beneficial effect, if so whether autophagy associated with...
Abstract Myocardial ischemia/reperfusion injury (MIRI) is a common clinical complication that occurs upon reperfusion therapy for acute myocardial infarction. Recent studies indicated impaired autophagic flux contributes to MIRI-induced apoptosis of cardiomyocytes (CMs). Fibroblast growth factor 10 (FGF10), multifunctional FGF family member, was reported protect against renal and hepatic injury. However, it has not been investigated whether FGF10 similar beneficial effect MIRI, if so,...