A5101618543- Fibroblast Growth Factor Research
- Autophagy in Disease and Therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wound Healing and Treatments
- Congenital heart defects research
- Dermatologic Treatments and Research
- Metabolism, Diabetes, and Cancer
- Caveolin-1 and cellular processes
- Hedgehog Signaling Pathway Studies
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Nitric Oxide and Endothelin Effects
- Wnt/β-catenin signaling in development and cancer
- Ovarian cancer diagnosis and treatment
- Kruppel-like factors research
- Cancer Risks and Factors
- Skin and Cellular Biology Research
- Systemic Sclerosis and Related Diseases
Wenzhou Medical University
2021-2025
Zhejiang Lab
2023-2025
Qidong Liver Cancer Prevention Research
2020
Abstract Delaying senescence of cardiomyocytes has garnered widespread attention as a potential target for preventing cardiovascular diseases (CVDs). FGF13 (Fibroblast growth factor 13) been implicated in various pathophysiological processes. However, its role premature myocardial aging and cardiomyocyte remains unknown. Adeno‐associated virus 9 (AAV9) vectors expressing cardiac‐specific Fgf13 knockout (Fgf13KO) mice are utilized to reveal that overexpression deficiency exacerbated...
Protein S-nitrosylation is a reversible protein modification implicated in both physiological and pathophysiological regulation of function. However, the relationship between dysregulated homeostasis diabetic vascular complications remains incompletely understood. Here, we demonstrate that basic fibroblast growth factor (bFGF) key regulatory link inflammation, alleviated endothelial dysfunction angiogenic defects diabetes. Subjecting human umbilical vein cells (HUVECs) to hyperglycemia...
Abstract Diabetes is a chronic disease characterized by perturbed glucose and lipid metabolism, resulting in high blood levels. Many complications induced endothelial dysfunction can cause disability even death of diabetic patients. Here, we found that the protein level casein kinase 2α (CK2α) was increased endothelium mice with type I diabetes (T1D) streptozotocin (STZ) injection. Although potential correlation between CK2α established, contribution to progression remained largely unknown....
Studies of diabetic glomerular injury have raised the possibility developing useful early biomarkers and therapeutic approaches for treatment type 2 nephropathy (T2DN). In this study, we found that FGF13 expression is induced in endothelial cells (GECs) during T2DN progression. Endothelial-specific deletion Fgf13 potentially alleviates damage, while overexpression has opposite effect. Mechanistically, deficiency results improved mitochondrial homeostasis barrier integrity T2DN. Moreover,...
Abstract myocardial ischemia/reperfusion injury (MIRI) is a common clinic scenario that occurs in the context of reperfusion therapy for acute infarction. Recent studies indicated impaired autophagic flux contributes to MIRI-induced cardiomyocytes (CMs) apoptosis. Fibroblast growth factor 10 (FGF10), multifunctional FGF family member, was reported exert protective effect against renal and hepatic injury. Whether FGF10 has similar beneficial effect, if so whether autophagy associated with...
Abstract Myocardial ischemia/reperfusion injury (MIRI) is a common clinical complication that occurs upon reperfusion therapy for acute myocardial infarction. Recent studies indicated impaired autophagic flux contributes to MIRI-induced apoptosis of cardiomyocytes (CMs). Fibroblast growth factor 10 (FGF10), multifunctional FGF family member, was reported protect against renal and hepatic injury. However, it has not been investigated whether FGF10 similar beneficial effect MIRI, if so,...
Objective: To estimate the incidence/mortality of ovarian cancer in 2015 and trend from 2006 to Jiangsu province, provide evidence for prevention treatment Jiangsu. Methods: The incidence death data collected 35 registries verified by provincial CDC 2018 were used extraction data. stratified urban rural, gender age groups. crude rates mortality, age-standardized (ASIR/ASMR), cumulative (0-74 years) truncated (35-64 calculated. Chinese population census 2000 world Segi's standard calculations...