A5101486277- Advanced Mathematical Physics Problems
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Helicobacter pylori-related gastroenterology studies
- Sarcoidosis and Beryllium Toxicity Research
- Transplantation: Methods and Outcomes
- Adipose Tissue and Metabolism
- COVID-19 and Mental Health
- Pancreatitis Pathology and Treatment
- Mental Health Research Topics
- Mitochondrial Function and Pathology
- Pancreatic and Hepatic Oncology Research
- Redox biology and oxidative stress
- Nutrition and Health in Aging
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal motility and disorders
- Liver Disease and Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
China-Japan Friendship Hospital
2022-2025
Affiliated Hospital of Southwest Medical University
2016-2025
Shandong Women’s University
2025
Shandong University
2025
National Clinical Research
2023-2024
Academy of Medical Sciences
2023-2024
First Affiliated Hospital of Sichuan Medical University
2013-2024
Respiratory Clinical Trials
2024
National Clinical Research Center for Digestive Diseases
2022-2023
Oxidative stress and chronic inflammation play key roles in the pathogenesis of obstructive pulmonary disease (COPD). Astaxanthin (AXT) is a keto-carotenoid with variety biological functions, including antioxidant anti-inflammatory effects This study aimed to explore protective role underlying mechanism AXT COPD. In this study, we found alleviated emphysema CS-exposed mouse model regulated expression MMP-9/TIMP-1. And, attenuates CSE-induced small airway fibrosis. Meanwhile, inhibited...
Abstract Background Skeletal muscle dysfunction is an important co‐morbidity in patients with chronic obstructive pulmonary disease (COPD) and significantly associated increased mortality. Oxidative stress has been demonstrated trigger for COPD‐related skeletal dysfunction. Glycine‐histidine‐lysine (GHK) active tripeptide, which a normal component of human plasma, saliva, urine; promotes tissue regeneration; acts as anti‐inflammatory antioxidant properties. The purpose this study was to...
Sarcopenia is common in patients with chronic obstructive pulmonary disease (COPD) and mainly caused by systemic inflammation. Resistin acts as a proinflammatory cytokine involved the activation of multiple inflammatory signaling pathways. The aim this study was to determine relationship between resistin levels inflammation assess clinical value circulating for sarcopenia COPD.
Silicosis is the most common type of pneumoconiosis, having a high incidence in workers chronically exposed to crystalline silica (CS). No specific medication exists for this condition. GHK, tripeptide naturally occurring human blood and urine, has antioxidant effects. We aimed investigate therapeutic effect GHK-Cu on silicosis its potential underlying molecular mechanism. An experimental mouse model was established observe effects lung inflammation fibrosis. Moreover, alveolar macrophages...
The associations between Chinese visceral adiposity index (CVAI) and non-alcoholic fatty liver disease (NAFLD) or hepatic fibrosis in Westerners are not obvious. Furthermore, metabolic dysfunction-associated steatotic (MASLD) is the new nomenclature of NAFLD, with significantly different diagnostic criteria. present study aimed to investigate relationships CVAI MASLD an American population, as well assess value for fibrosis. After excluding missing data on calculations indices, diagnosis...
Numerous studies have demonstrated that the presence of IUAs can detrimental effects on female reproductive function, potentially leading to infertility. Hysteroscopic adhesiolysis is widely regarded as primary treatment for IUAs. A 2021 consensus development study top 10 research priorities future infertility suggested impact live birth rates after surgical mild uncertain. The was a retrospective cohort included 442 patients who were diagnosed with and underwent embryo transfer (fresh or...
Background & aim The coronavirus disease 2019 (COVID-19) pandemic has affected the life and work of people worldwide. present study aimed to evaluate rhythm disruptions life, work, entertainment, their associations with psychological impacts during initial phase COVID-19 pandemic. Method A cross-sectional was conducted from 10 th 17 March 2020 in China. structured e-questionnaire containing general information, Chinese version Brief Social Rhythm Scale, Zung’s self-rating scales...
Pyruvate kinase M2 (PKM2), a key protein in glucose and lipid metabolism, has been reported to be related carcinogenesis various malignancies. However, its roles hepatocellular carcinoma with cirrhotic liver (CL) non-cirrhoticliver (NCL) haves not investigated. In our study western bloting, qRT-PCR immunohistochemistry were performed evaluate the clinical significance of PKM2 expression CL NCL. The results revealed that was significantly higher HCC tissues than their adjacent non-tumour...
Hookworm infections are widely prevalent in tropical and subtropical areas, especially low income regions. In the body, hookworms parasitize proximal small intestine, leading to chronic intestinal hemorrhage iron deficiency anemia. Occasionally, can cause overt gastrointestinal bleeding, but this is often ignored heavily burdened individuals from endemic infectious areas. A total of 424 patients with obscure bleeding were diagnosed by numerous blood tests or stool examinations as well...
Fixed airflow limitation (FAO), prevalent in patients with severe or difficult-to-treat asthma, is mainly caused by airway remodeling. Airway remodeling initiated inflammation and involves subsequent pathological changes. Glycyl-l-histidyl-l-lysine (GHK) a matrikine anti-inflammatory antioxidant effects, naturally existing human tissue. At present, the GHK level plasma whether it related to of asthma remain unclear. This study was conducted determine how involved asthma. Our result showed...
Abstract Rationale and objectives Bleeding is a major complication of transbronchial lung cryobiopsy (TBLC), pre-placing bronchial balloon one the clinical practices used to prevent it, but with very weak evidence, which should be confirmed. This study aimed conduct whether in TBLC for diagnosing interstitial disease (ILD) more safety. Materials methods In this prospective, single-center, randomized controlled trial, patients suspected ILD were enrolled randomly assigned pre-placed...
Tuberculous pleurisy (TP) is a common type of extrapulmonary tuberculosis (EPTB). With the development research and changes in TP patient characteristics, an increasing number studies have revealed prevalence, risk factors, novel diagnosis techniques. Thus, this bibliometric analysis was performed to identify global scientific output characteristics hotspots frontiers for over past 15 years. We searched Web Science Core Collection (WoSCC) Citation Index Expanded (SCI-expanded) literature...
Abstract BACKGROUND and OBJECTIVE The rhythms of life, work entertainment behaviours are considered as the external behavioural manifestations biological rhythm.To evaluate distinctive disrupted their associations with mental health problems in people different backgrounds under stress COVID-19 epidemic. SUBJECTS AND METHODS A cross-sectional study was conducted from 10-17 March 2020 epidemic.A structured e-questionnaire containing general information,rhythm scale(subscale1 for life-work...
The improvement of digestive cancer survival results in increased morbidity noncancerous comorbidities. This study aimed at clarifying causes death (COD) and predicting overall (OS) patients diagnosed with liver cancer, gallbladder cholangiocarcinoma, pancreatic cancer. We used the Surveillance, Epidemic, End Results database to extract information. Nomograms multivariate Cox regression was predict OS patients. models were evaluated using concordance indexes (C-indexes), receiver operating...