Consanguinity, defined as a blood relation between couples, is associated with genetic diseases in their offspring. In Saudi Arabia, obesity considered major health problem increased risks of cardiovascular disease, insulin resistance, and type 2 diabetes mellitus. Angiotensin-converting enzyme (ACE) insertion (I) deletion (D) polymorphisms an Alu-287 bp sequence has been implicated multiple metabolic disorders, including obesity. To date, no studies have conducted the population regarding...

Enterobacter hormaechei is involved in multiple hospital-associated infections and resistant to beta-lactam tetracycline antibiotics. Due emerging antibiotics resistance E. lack of licensed vaccine availability, efforts are required overcome the crisis. In current research study, a multi-epitope-based against was designed using reverse vaccinology immunoinformatic approaches. A total number 50 strains were analyzed from which core proteome extracted. One extracellular (curlin minor subunit...

Whipple's disease is caused by T. whipplei, a Gram-positive pathogenic bacterium. It considered persistent infection affecting various organs, more likely to infect males. There currently no licensed vaccination available for disease; thus, the development of chimeric peptide-based vaccine against whipplei has potential be tremendously beneficial in preventing future. The present study aimed apply modern computational approaches generate multi-epitope-based that expresses antigenic...

Cancer patients often face challenges in managing their disease, particularly with regard to contraindications related medications, foods, and physical activity, which can negatively affect treatment outcomes. This study aimed evaluate cancer patients' awareness of these explore the influence sociodemographic factors, support systems, comorbidities, medication use on knowledge. A cross-sectional prospective was conducted 125 Saudi Arabia between December 2022 February 2023. Participants were...

This study aimed to assess the prevalence of non-communicable diseases (NCDs) among Saudi adolescents, focusing on obesity, conduct disorder, asthma, and anxiety, identify potential risk factors associated with these conditions. A retrospective cross-sectional analysis was conducted using data from 2,160 adolescents sourced official government databases peer-reviewed literature. Statistical methods included one-way ANOVA, chi-square tests, logistic regression, Pearson's correlation...

Vitiligo is a skin depigmentation condition caused by the immune-mediated perdition of melanocytes. In vitiligo, cytotoxic T-lymphocytes damage melanocytes, causing depigmentation. The Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene has been reported to be related vitiligo and other autoimmune diseases. purpose this study was explore molecular involvement rs231775 rs3087243 SNPs in CTLA4 patients. recruitment based on sample size calculation it, we have recruited 300 Saudi individuals who...

Introduction Obesity has emerged as a significant public health concern in Saudi Arabia, with rising prevalence rates contributing to an increased risk of chronic diseases such diabetes and cardiovascular disorders. Community pharmacists, accessible healthcare providers, hold the potential play critical role weight management. This study aimed explore beliefs, practices, barriers encountered by community pharmacists Arabia regarding Methods A cross-sectional survey was conducted among gather...

Type 2 diabetes mellitus (T2DM) is a chronic and metabolic disorder that affects the adult population. Chemokines are proinflammatory cytokines play role in development of diseases such as obesity, gestational diabetes, T2DM. The C-C Motif Chemokine Ligand 5 (CCL5) gene plays antiviral immunity, tumor development, impaired glucose tolerance, This study aimed to investigate genetic rs2107538 variant CCL5 Saudi patients with Sixty subjects T2DM 60 healthy controls participated this prospective...

Diabetes (hyperglycemia) is defined as a multifactorial metabolic disorder in which insulin resistance and defects pancreatic β-cell dysfunction are two major pathophysiologic abnormalities that underpin towards gestational diabetes mellitus (GDM). TCF7L2, KCNQ1, KCNJ11 genes connected to the mechanism of dysfunction. The purpose this study was investigate associated with their genetic roles rs7903146, rs2237892, rs5219 variants Saudi women diagnosed type 2 GDM.In case-control study, 100 GDM...

Polycystic ovary syndrome (PCOS) is an ovarian health condition as well a long-term endocrine dysfunction that affects reproductive-aged women. Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, the prevalence of obesity rising in Saudi Previous studies on rs5743708 polymorphism were documented In this study, we investigated molecular role TLR2 among women diagnosed with using Rotterdam criteria. Blood samples collected from 220 hospital-based case-control study;...

Limited studies have shown positive and negative associations of serum amylase A1 (SAA1) gene in childhood obesity, previously showed the relation with obesity different ethnicity. The current study therefore investigated impact single nucleotide polymorphisms present SAA1 on subjects Saudi obesity.In this case-control study, we selected 140 population categorized them into 83 cases 57 healthy controls. Genotyping was performed quantitative/real time-polymerase chain reaction for...

The traditional definition of gestational diabetes mellitus (GDM) is the leading cause carbohydrate intolerance in hyperglycemia varying severity, with onset or initial detection during pregnancy. Previous studies have reported a relationship among obesity, adiponectin (ADIPOQ), and Saudi Arabia. ADIPOQ an adipokine that produced secreted by adipose tissue involved regulation fatty acid metabolism. This study investigated molecular association between rs1501299, rs17846866, rs2241766...

Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented type 2 diabetes mellitus (T2DM) and other diseases Saudi population. We investigated relationship between rs11536889, rs4986790, rs4986791 SNPs TLR4 T2DM population; 105 patients with healthy controls were analyzed. The was amplified through PCR, followed by restriction fragment length polymorphism analysis for Sanger sequencing rs11536889 rs4986790 SNPs. clinical biochemical characteristics...

Background: This study explored the association between ApaI–TaqI Single Nucleotide Polymorphisms (SNPs) in a Vitamin D receptor (VDR) and risk of Gestational Diabetes Mellitus (GDM) Saudi women, along with serum levels vitamin D. Methods: Ninety women GDM 90 non-GDM were enrolled, based on inclusion exclusion criteria for pregnant enrolled single-center study. Blood samples retrieved from 180 using ethylenediaminetetraacetic acid (EDTA) tubes. Serum used to measure D, 25-hydroxyvitamin...

Non-diabetic women with polycystic ovarian syndrome (PCOS) often have abnormal insulin regulation. Calpain 10 (CALP10) is a biomarker of type 2 diabetes mellitus, some its single-nucleotide polymorphisms (SNPs) influencing PCOS development.

Surface Ozone (O3) is the most phyto-toxic among air pollutants. Okra was grown in summer and Peas winter, 2014, were subjected to EDU crop experiments assess its response tropospheric O3 norther Pakistan. The concentration via ozone monitor during okra experiment ranged from 43 63ppb with mean of 55ppb. peas 15 25ppb 19ppb winter. significantly affected Ash, Protein, Fiber NFE content NEDU treated seeds by 20%, 29%, 13% 9.5%, respectively, Fiber, Fats contents lowered 15% 4%, 8% 9%...