A5087046935- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Muscle Physiology and Disorders
- Transgenic Plants and Applications
- Cardiomyopathy and Myosin Studies
- Cancer therapeutics and mechanisms
- Microtubule and mitosis dynamics
- Phytochemistry and Biological Activities
- Cancer Mechanisms and Therapy
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Diverse Scientific Research Studies
- Phytochemical Studies and Bioactivities
- Complement system in diseases
- Botanical Research and Applications
- Bioactive Compounds in Plants
- Lipid Membrane Structure and Behavior
- thermodynamics and calorimetric analyses
- Medicinal Plants and Neuroprotection
- Trypanosoma species research and implications
- Immunotoxicology and immune responses
- Rheumatoid Arthritis Research and Therapies
Najran University
2021-2024
King Faisal University
2024
Huntington Medical Research Institutes
2024
Health Affairs
2024
Directorate of Health
2024
Shaqra University
2024
King Khalid University
2024
Universiti Sains Malaysia
2024
University of Leicester
2014
For the last few years, world has been going through a difficult time, and reason behind this is severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), one of significant members Coronaviridae family. The major research groups have shifted their focus towards finding vaccine drugs against SARS-CoV-2 to reduce infection rate save life human beings. Even WHO permitted using certain vaccines for an emergency attempt cut curve down. However, virus great sense mutation, vaccine's...
The coronaviruses belong to the Coronaviridae family, and one such member, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing significant destruction around world in form of a global pandemic. Although vaccines have been developed, their effectiveness level protection still major concern, even after emergency approval from World Health Organisation (WHO). At community level, no natural medicine currently available as cure. In this study, we screened vast library Drug...
The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways weaken this virus, prevent its and also eliminate it. However, no drug been approved treat COVID-19. Furthermore, receptor-binding domain (RBD) on viral spike protein, well several other important parts have recently undergone mutations, resulting in new virus variants. While treatment is currently available, naturally derived molecule with antiviral properties could be used potential...
The coronaviridae family has caused the most destruction among all viral families in modern sciences. It is one of recently discovered and added members severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which global pandemic significant worldwide. However, scientists worldwide have developed vaccines, are being given to humans. mutated strain virus various uncertainties about whether drug vaccines affect it. Even after World Health Organization's approval for their effectiveness...
The major goal of this investigation was to prepare a drug delivery polymeric nanoparticles (NPs) from 5-fluorouracil (FU) that could be delivered intravenously and improve the therapeutic index FU. In order achieve this, interfacial deposition method used FU entrapped poly-(lactic-co-glycolic acid) (FU-PLGA-NPs). influence various experimental settings on effectiveness integration into NPs assessed. Our findings show technique organic phase ratio aqueous had greatest impact NPs. results...
Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned investigate the pharmacological foundations for therapeutic effectiveness of P. in illnesses and its underlying mechanisms. Ex vivo vaso-relaxant effects crude leaf extract were observed rabbit aorta ring preparations. Hypotensive measured using pressure force transducers connected Power Lab data acquisition system. Furthermore, displayed...
Lead (Pb) is a widespread and nondegradable environmental pollutant affects several organs through oxidative mechanisms. This study was conducted to investigate the antioxidant protective effect of glycine betaine (GB) against Pb-induced renal hepatic injury. Male albino rats (n = 45) were divided into three groups: G1 untreated control, G2 Pb-acetate (50 mg/kg/day), G3 mg/kg/day) plus GB (250 administered for 6 weeks. For G3, first followed by at least 4 h after. treatment (G2) resulted in...
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, suicidal cell death red blood cells (RBCs), may account for CIA as it triggered by clinically approved chemotherapeutics including cisplatin paclitaxel. Physcion (PSN), an anthraquinone extracted from rhubarb other plants, has shown great promise anticancer agent. However, potential toxicity PSN to RBCs remains elusive. were isolated heparinized blood,...
In this study, pEGFP-LUC was used as a model plasmid and three distinct cationic lipids (dioleyloxy-propyl-trimethylammonium chloride [DOTMA], dioleoyl trimethylammonium propane [DOTAP], cetylpyridinium [CPC]) were tested along with PEG 5000, nonionic surfactant, to prepare glyceryl monostearate (GMS)-based solid lipid nanoparticles (cSLNs). Both the type quantity of surfactant had an impact on physicochemical characteristics cSLNs. Thermal analysis greater part endothermic peaks cSLNs...
Incorporating dried corn silk powder (CSP) into food products is considered beneficial for health and suitable individuals of all ages. Thus, our study designed to evaluate the effects adding CSP prepared cookies as a nontraditional source dietary fiber natural antioxidants, focusing on chemical composition, physical properties, color attributes, antioxidant activity, sensory properties fortified cookies. Different proportions (5%, 10%, 15%, 20%) replaced wheat flour (WF) with 72% extraction...
To ascertain the prevalence of transfusion transmissible infections (TTIs) across diverse donor groups in Najran province. Additionally, to establish a potential association between development TTI and donors' blood group, as determined by ABO/Rh grouping system.
The potential benefits of biodegradable and functional food packaging materials have garnered increasing attention in recent years. Sodium alginate (SA), a commonly utilized polysaccharide, is particularly noteworthy for producing films packaging. This study aimed to investigate SA-based edible enriched with various proportions cactus pear peel extract (CPPE). We assessed the extracts total phenolic content, antimicrobial antioxidant activities, as well mechanical properties. Cactus peels...
AbstractAlzheimer's disease (AD) is a neurological disorder that progresses gradually but irreversibly leading to dementia and difficult prevent treat. There considerable time window in which the progression of can be intervened. Scientific advances were required help researchers identify effective methods for prevention treatment disease. This research was designed investigate potential mediators remedy AD, five new carboxylate amide zinc complexes (AAZ9–AAZ13) synthesized characterized by...
Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects currently used aromatase inhibitors (AIs) necessitate development new AIs that are more active, selective, and less toxic. This study computational approach to screen 503 natural compounds ZINC database against active site. best scoring hits ZINC69482055, ZINC69482510, ZINC406719 exhibited strong binding with aromatase, energy values -8.45, -10.35, -8.75...
Abstract Cervical cancer remains a significant global health concern that starts in the cervix, lower part of uterus connects to vagina and is caused by human papillomavirus (HPV), necessitating development effective multitargeted resistance-proof therapies. In early-stage cervical may not show any symptoms, however, as progresses, some people experience- abnormal vaginal bleeding, watery or bloody discharge, pain pelvis back, during sex, frequent painful urination. this study, we screened...
Properdin, a serum glycoprotein, is involved in the immune system regulation, particularly alternative pathways beginning complement system. Properdin made up of cyclic oligomers monomeric subunits and generated by various leukocyte subsets. promotes activation, which results changes withinside cell milieu that makes contributions to innate adaptive immunological responses, such as generation pro-inflammatory cytokines, recruitment, development cells antigen presentation. Despite presence...