A5052948631- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Traumatic Brain Injury Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Cardiac Arrest and Resuscitation
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cerebrospinal fluid and hydrocephalus
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Trauma and Emergency Care Studies
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Cancer Cells and Metastasis
- Vascular Malformations Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
Royal College of Surgeons in Ireland
2011-2024
Queen Elizabeth Hospital Birmingham
2022-2024
Beaumont Hospital
2013-2023
Toronto Western Hospital
2020-2023
University Health Network
2020-2023
University of Toronto
2020-2023
Botsford Hospital
2023
Beaumont Hospital, Dearborn
2023
Royal London Hospital
2021-2022
Children's Health Ireland at Crumlin
2022
Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvant treatment regimens and the microenvironment. Consequences of these alterations remain poorly understood, as does their potential for clinical targeting. We utilized genome-wide molecular profiling identify therapeutic targets acquired in metastatic disease.Gene expression 21 patient-matched primary breast tumors associated was performed TrueSeq RNA-sequencing determine clinically actionable BrM target...
New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts subtype patients based on molecular profiles have failed direct treatment strategies. We hypothesised that interrogation of the GBM tumour microenvironment (TME) and identification novel TME-specific subtypes could inform new immunotherapy strategies.A refined validated cell population (MCP) counter method was applied >800 patient tumours (GBM-MCP-counter). Specifically, partition around...
Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit high recurrence rate, some pursue more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk early tumour progression determine whether related outcome. Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 2014 were included. MRI pathology characteristics assessed. Gross total resection...
Abstract Background Patient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be established whether loss of situ microenvironment affects clinically-predictive value this model. We implemented a GSC monolayer system investigate - vitro molecular correspondence and relationship between patient response temozolomide (TMZ). Methods DNA/RNA-sequencing was performed on 56 glioblastoma tissues 19 derived cultures. Sensitivity...
Abstract Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imaging. Pyradiomics was employed to extract CT-radiomic features from the tumour-implanted hemisphere non-tumour-implanted of acquired CT-scans. Inter-correlated removed (Spearman correlation > 0.85) remaining underwent predictive analysis...
Glioblastoma (GBM) is an aggressive brain cancer that typically results in death the first 15 months after diagnosis. There have been limited advances finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 Long LTS).Patients were selected from in-house cohort (GLIOTRAIN-cohort), using defined inclusion criteria (Karnofsky score > 70; age < 70 years old; Stupp...
Purpose: Despite the clinical utility of endocrine therapies for estrogen receptor-positive (ER) breast cancer, up to 40% patients eventually develop resistance, leading disease progression. The molecular determinants that drive this adaptation treatment remain poorly understood. Methylome aberrations cancer growth yet functional role and mechanism these epimutations in drug resistance are elucidated.Experimental Design: Genome-wide multi-omics sequencing approach identified a differentially...
Abstract Introduction Bevacizumab has demonstrated activity in glioblastoma (GBM), but the true benefits and optimal dose‐schedule are debated. A lower than standard‐dose bevacizumab (10 mg/kg 2‐weekly) might offer similar with costs. At our Institution, patients randomly assigned at time of primary diagnosis to Neuro‐Oncologists, who have varying practices terms upon progression. Methods In a retrospective analysis we examined overall survival (OS), measured from first administered dose...
Abstract Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks drive disease progression. In primary breast cancer, the coactivator AIB1 promotes estrogen receptor (ER) activity enhance cell proliferation. The function of in ER + metastasis however is not established. Here we describe as a survival factor, regulator pro-metastatic pathways promising actionable target. Genomic alterations functional expression with...
Differentiation of radiation necrosis from tumor progression in brain metastases treated with stereotactic radiosurgery (SRS) is challenging. For this, we assessed the performance centrally restricted diffusion sign.Patients SRS who underwent a subsequent intervention (biopsy/resection) for ring-enhancing lesion on preoperative MRI between 2000 and 2020 were included. Excluded lesions containing increased susceptibility limiting assessment DWI. Two neuroradiologists classified location...
Medulloblastoma is the most common malignant paediatric brain tumour, representing 20% of all intercranial tumours. Current aggressive treatment protocols and use radiation therapy in particular are associated with high levels toxicity significant adverse effects, long-term sequelae can be severe. Therefore, improving chemotherapy efficacy could reduce current reliance on therapy. Here, we demonstrated that systems-level analysis basal apoptosis protein expression their signalling...
Eddy, J.J.; Gideonsen, M.D.; Song, J.Y.; Grobman, W.A.; O'Halloran, P. Author Information
Introduction: Endoscopic endonasal approach (EEA) has become the preferred surgical for resection of pituitary adenomas in most centers. This technique a number advantages such as improved visualization and maneuverability, when compared to microscopic transsphenoidal approach. However, long-term results this are still scarce. Ten years ago, we published our initial series patients having undergone an endoscopic removal their reporting favorable short-term results. project aims revisit that...
Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis common and devastating site relapse for several molecular subtypes, including oestrogen receptor-positive disease, with life expectancy less than year. While efforts have been devoted to developing therapeutics extra-cranial metastasis, drug penetration blood-brain barrier (BBB) remains clinical challenge. Defining alterations brain enables the identification novel actionable targets.Global...
Laser interstitial thermal therapy (LITT) represents an attractive therapeutic strategy for several intracranial pathologies; however, there is a paucity of literature regarding its efficacy the treatment gliomas.MEDLINE, EMBASE, Scopus, and Web Science were searched from inception until March 19, 2021. Studies specifically relating to use LITT in glioma eligible inclusion. A meta-analysis means was performed assess progression-free survival (PFS) overall (OS) following descriptive...