A5048278111- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- MRI in cancer diagnosis
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Neuroimaging Techniques and Applications
- Cancer Mechanisms and Therapy
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
- Peripheral Nerve Disorders
- Cancer-related gene regulation
- Cancer Research and Treatments
- Colorectal Cancer Surgical Treatments
- Appendicitis Diagnosis and Management
- Neurofibromatosis and Schwannoma Cases
- Cytokine Signaling Pathways and Interactions
- Brain Tumor Detection and Classification
- Renal and related cancers
- Medical Imaging and Analysis
- Diverticular Disease and Complications
- Tactile and Sensory Interactions
- Neurobiology of Language and Bilingualism
Universidad de Cantabria
2022-2024
Instituto de Investigación Marqués de Valdecilla
2015-2024
Marqués de Valdecilla University Hospital
2016-2024
Fundación Marques de Valdecilla
2023-2024
Neurological Surgery
2023-2024
Hamad Medical Corporation
2024
University of Toronto
2018-2023
University of Göttingen
2022
University of Birmingham
2022
National Institute for Health Research
2022
Purpose To evaluate the prognostic and predictive value of surface-derived imaging biomarkers obtained from contrast material–enhanced volumetric T1-weighted pretreatment magnetic resonance (MR) sequences in patients with glioblastoma multiforme. Materials Methods A discovery cohort five local institutions (165 patients; mean age, 62 years ± 12 [standard deviation]; 43% women 57% men) an independent validation (51 60 12; 39% 61% The Cancer Imaging Archive contrast-enhanced MR were included...
Objective: The main objective of this retrospective work was the study three-dimensional (3D) heterogeneity measures post-contrast pre-operative MR images acquired with T1 weighted sequences patients glioblastoma (GBM) as predictors clinical outcome. Methods: 79 from 3 hospitals were included in study. 16 3D textural computed including run-length matrix (RLM) features (regional heterogeneity) and co-occurrence (CM) (local heterogeneity). significance results studied using Kaplan–Meier curves...
Purpose Textural measures have been widely explored as imaging biomarkers in cancer. However, their robustness under dynamic range and spatial resolution changes brain 3D magnetic resonance images (MRI) has not assessed. The aim of this work was to study potential variations textural due MRI protocols. Materials methods Twenty patients harboring glioblastoma with pretreatment T1-weighted MRIs were included the study. Four different combinations three ranges studied for each patient. Sixteen...
International collaborations between high-income (HICs) and low- middle-income countries (LMICs) have been developed as an attempt to reduce the inequalities in surgical care around world. In this paper authors review different models for international education describe projects by Division of Neurosurgery at University Toronto field.The conducted a reported literature last 15 years. Previous publications on global neurosurgery were reviewed exemplify applications challenges...
Transsphenoidal surgery is advocated as the first-line management of growth hormone (GH)-secreting adenomas. Although disease control defined by strict criteria for biochemical remission, length follow-up needed not well in literature. In this report, authors present their long-term remission rate and identify various predictive factors that might influence clinical outcome.
OBJECTIVE The functional importance of the superior temporal lobe at level Heschl’s gyrus is well known. However, organization and function these cortical areas underlying fiber tracts connecting them remain unclear. goal this study was to analyze area formed by intersection gyrus–related tracts, which authors have termed “Heschl’s area” (HGFIA). METHODS subcortical connectivity analyzed white matter dissection diffusion tensor imaging tractography. organized in relation were isolated 8...
Abstract Purpose Hepatocellular carcinoma (HCC) is one of the most common types liver cancer that could potentially be surrounded by healthy arteries or veins a surgeon would have to avoid during treatment. A realistic 3D model an unmet need for HCC preoperative planning. Methods This paper presents method create soft phantom human with help 3D-printed mold, silicone, ballistic gel, and blender. Results For elastic modulus seven different ratios base silicone hardener are tested; while using...
The transmembrane protein ODZ1 has been associated with the invasive capacity of glioblastoma (GBM) cells through upregulation RhoA/ROCK signaling, but mechanisms triggering pathway remain elusive. In addition, it is widely accepted that hypoxia one main biological hallmarks GBM microenvironment and treatment resistance poor prognosis. Here we show hypoxic tumor regions express higher levels induces expression in by regulating methylation status promoter. Hypoxia-induced correlates migration...
Abstract BACKGROUND An early maximal safe surgical resection is the current treatment paradigm for low-grade glioma (LGG). Nevertheless, there are no reliable methods to accurately predict axonal intratumoral eloquent areas and, consequently, extent of resection. OBJECTIVE To describe functional predictive value white matter tracts within tumor by using a pre- and postoperative diffusion tensor imaging (DTI) tractography protocol in patients with LGG. METHODS A preoperative DTI-based...
This report describes a reliable and simple technique for securing external ventricular drains (EVDs) to the scalp avoiding pullout complications. The operative consists of fixing drain between 2 hydrocolloid dressings it with staples. A 10-year retrospective analysis EVD complications was performed in series 435 consecutive patients who were treated at single institution. complication rate 0.4%. No related fixation found. median time required fix 60 seconds. presented here is procedure...
OBJECTIVE The objective of this study was to describe the outcomes outpatient oncological neurosurgery (OON) in a European clinical setting and compare them with conventional inpatient protocol. METHODS Patients who had undergone OON (either tumor removal or biopsy) at authors’ center since 2019 were analyzed. A matched cohort patients selected from undergoing surgery same period. Collected data included patient demographics, postoperative progress, specific location target lesion, procedure...
Purpose To evaluate the prognostic and predictive value of surface-derived imaging biomarkers obtained from contrast material–enhanced volumetric T1-weighted pretreatment magnetic resonance (MR) sequences in patients with glioblastoma multiforme. Materials Methods A discovery cohort five local institutions (165 patients; mean age, 62 years ± 12 [standard deviation]; 43% women 57% men) an independent validation (51 60 12; 39% 61% The Cancer Imaging Archive contrast-enhanced MR were included...
<h3>BACKGROUND AND PURPOSE:</h3> Multifocal glioblastomas (ie, with multiple foci, unconnected in postcontrast pretreatment T1-weighted images) represent a challenge clinical practice due to their poor prognosis. We wished obtain imaging biomarkers prognostic value that have not been found previously. <h3>MATERIALS METHODS:</h3> A retrospective review of 1155 patients from 10 local institutions during 2006–2017 provided 97 satisfying the inclusion criteria study and classified as having...
Introduction: Endoscopic endonasal approach (EEA) has become the preferred surgical for resection of pituitary adenomas in most centers. This technique a number advantages such as improved visualization and maneuverability, when compared to microscopic transsphenoidal approach. However, long-term results this are still scarce. Ten years ago, we published our initial series patients having undergone an endoscopic removal their reporting favorable short-term results. project aims revisit that...