A5101697981- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Pelvic floor disorders treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Trauma and Emergency Care Studies
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Stoma care and complications
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
- Emergency and Acute Care Studies
- Peptidase Inhibition and Analysis
- Appendicitis Diagnosis and Management
- Gastrointestinal disorders and treatments
- Patient-Provider Communication in Healthcare
- Injury Epidemiology and Prevention
- Digital Games and Media
- Esophageal and GI Pathology
- Estrogen and related hormone effects
- Intestinal Malrotation and Obstruction Disorders
- Ureteral procedures and complications
- Foreign Body Medical Cases
- Colorectal Cancer Treatments and Studies
The University of Sydney
2002-2024
Royal Prince Alfred Hospital
2012-2024
Royal College of Surgeons in Ireland
2011-2020
Sydney Local Health District
2013-2019
The University of Texas at Austin
2019
Society of Surgical Oncology
2019
Baylor College of Medicine
2011-2014
University College Dublin
2011-2014
Sydney South West Area Health Service
2007-2013
Services Australia
2013
Surgery for recurrent rectal cancer is the only therapy with curative potential. This study was designed to assess factors that affect survival after surgery locally cancer.Prospective databases of patients undergoing surgical resection at three tertiary centers between 1990 and 2006 were combined analyzed. Cox regression Kaplan-Meier analysis used associated survival.A total 160 (96 males) underwent (median age, 63 (range, 27-93) years). Ninety-five (59 percent) received neoadjuvant...
To investigate the effectiveness of a centralized, nurse-delivered telephone-based service to improve care coordination and patient-reported outcomes after surgery for colorectal cancer.Patients with newly diagnosed cancer were randomly assigned CONNECT intervention or usual care. Intervention-group patients received standardized calls from centrally based nurse 3 10 days 1, 3, 6 months discharge hospital. Unmet supportive needs, experience coordination, unplanned readmissions, emergency...
Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen metastatic melanoma were enrolled in phase two, randomized, open-label study comparing intralesional bleomycin+EPT bleomycin alone. Of 18 lesions, 13 (72%) showed complete response, one...
To determine surgical, survival and quality of life outcomes across different tumour streams lessons learned over 28 years.Consecutive patients undergoing pelvic exenteration at a single, high volume, referral hospital, between 1994 2022 were included. Patients grouped according to their type presentation as follows, advanced primary rectal cancer, other malignancy, locally recurrent malignancy non-malignant indications. The main included, resection margins, postoperative morbidity,...
Development of quality-of-life measures has been the focus research in colorectal disorders recent years. The assessment quality life for fecal incontinence should be more important than quantitative measurement soiling.This study assesses specific patient objectives, categorizes and correlates these objectives with continence scores.One hundred eighteen patients entered into a randomized, controlled trial biofeedback were assessed using Direct Questioning Objectives measure. All documented,...
Purpose: Biofeedback is well established as a treatment for fecal incontinence but little known about factors that may be associated with its effectiveness. This study assessed short-term outcomes, predictors of patients who completed treatment, and success. Methods: was retrospective review consecutive treated biofeedback at tertiary referral colorectal clinic during ten years. Clinical, physiologic, quality life measures were collected prospectively the time treatment. Regression analysis...
Laparoscopic rectopexy to treat full-thickness rectal prolapse has proven short-term benefits, but there is little long-term follow-up and functional outcome data available.Patients who had abdominal surgery for during a ten-year period were identified interviewed ascertain details of recurrence, constipation, incontinence, cosmesis, satisfaction. Additional on recurrences that required mortality obtained from chart review the State Death Registry.Of 321 operations, laparoscopic was...
Considerable progress has been made in the management of patients with locally advanced or recurrent cancers pelvis over past 60 years since inception pelvic exenteration. Early exenteration was marred by high surgical mortality and morbidity, which drew scepticism from broader community. Subsequent evolution procedure hinged on establishing safety a better understanding outcome predictors. Surgical is now comparable to that elective resection for primary colorectal cancers. The importance...
<b>Background and study aims:</b> Removal of colonic polyps prevents progression neoplasia. Miss rates range from 5 % to 32 %. The effect contractility on polyp detection has not been studied adequately. Hyoscine butylbromide results in spasmolysis may improve detection. <b>Patients methods: </b>Patients undergoing colonoscopy for standard indications were included randomized receive either 20 mg hyoscine or placebo at cecal intubation. Operators blind the intervention. Data indication,...
The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity that permits the emergence a hormone-independent tumor. steroid coactivator protein SRC-1, through interactions with developmental proteins and other nonsteroidal transcription factors, drives this tumor adaptability. In discovery study, we identified ADAM22, non-protease member ADAM family disintegrins, as direct estrogen receptor (ER)-independent target SRC-1. We confirmed SRC-1...
Purpose: Crohn's disease poses difficult choices in which the most appropriate treatment option is not always obvious. When this state of uncertainty exists, patients' preferences should have an increasingly important part clinical decision making. The purpose study was to compare for surgical intervention with surgeons and gastroenterologists. Methods: Outpatients were interviewed quantify their six scenarios by using prospective preference measure. An identical questionnaire mailed all...
Abstract Background Elderly patients with major trauma are an increasingly important public health concern. The objective of the study was to describe long term trend in aged 65 years and older trauma. Methods A retrospective single centre registry conducted at inner city Major Trauma Centre Sydney. Data on or (Injury Severity Score greater than 15) presenting between 1991 2010 were extracted from data registry. Demographic data, mechanism injury, injury severity scores outcomes collected....
Transcriptional control is the major determinant of cell fate. The steroid receptor coactivator (SRC)-1 enhances activity estrogen in breast cancer cells, where it confers survival benefits. Here, we report that a global analysis SRC-1 target genes suggested also mediates transcriptional repression cells. Combined and HOXC11 ChIPseq identified differentiation marker, CD24, apoptotic protein, PAWR, as direct SRC-1/HOXC11 suppression targets. Reduced expression both CD24 PAWR was associated...
1. Blind analysis of contrast echocardiograms to detect intracardiac shunts, blind lung function tests for evidence small airways disease, smoking history and dive characteristics were examined in an attempt explain neurological symptoms that occurred within 5 min surfacing from unprovocative dives. 2. Pulmonary abnormalities significantly more frequent those divers without shunts (50%) than with (0%). Smoking was common (55% versus 15%), although this just failed reach conventional...
Abstract Aim When treating patients with refractory ulcerative colitis ( UC ), the choice between escalating medical management or surgery can be difficult. The aim of this study was to quantify preferences and clinicians for treatment options in . Method Ulcerative outpatients were interviewed measure their five scenarios examining acute chronic , using a prospective preference method that generates two utility scores: willingness amount expected life trade gamble. A self‐administered...
Abstract Aim This study aimed to evaluate the long‐term outcome of anal fistula plug in treatment cryptoglandular origin. Method A review all patients who had at least one inserted from March 2007 August 2008 was performed. Only fistulae origin were included. Success defined as closure external opening with no further purulent discharge or collection. Results Thirty plugs 26 [median age 40 (26–70) years]. Twenty‐six transsphincteric and three suprasphincteric. One patient a high...
Abstract Objective This study aimed to determine the relative effect of elderly patients and increasing injury severity on acute hospital costs inpatient length stay. Methods A prospective all trauma team activations at a single inner city centre was conducted over 1‐year period. Costs were imputed using ustralian Refined D iagnosis‐ R elated G roups. stays compared between (age ≥65 years) non‐elderly patients. Relative effects score ( ISS ) age categories modelled generalized linear...
Biofeedback is an effective treatment for patients with fecal incontinence, yet little known about how it works or the minimum regime necessary to provide clinical benefit. This study compares effectiveness of a novel protocol telephone-assisted biofeedback living in rural and remote areas standard face-to-face incontinence.A new program comprising initial assessment transanal manometry ultrasound biofeedback, followed by three treatments conducted via telephone final assessment, was...
Fecal incontinence in systemic sclerosis can occur secondary to fibrous replacement of the internal sphincter or ischemic myopathy anal from vasculitis. Both lead morphologic changes on endoanal ultrasound. This study documents that occur.A retrospective consecutive patients with and fecal was performed. Endoanal ultrasound performed by using a 10 MHz Bruel Kjaer endoprobe. Internal thickness echogenecity were assessed at mid canal prospectively collected images. Sphincter thicknesses...
Abstract Aim The aim was to compare the effectiveness of chewing sugar‐free gum after bowel resection on function and length stay. Method This a randomized controlled trial patients undergoing elective open or laparoscopic surgery, who were allocated into two groups: group ( CG ); nonchewing NG ). Primary outcomes time discharge (length hospital stay [ LOS ]), first flatus TFF ) motion TBM Secondary complication rates, pain total morphine equivalent TME q) medication for 7 days procedure....