A5008961864- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Airway Management and Intubation Techniques
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Infant Development and Preterm Care
- Inhalation and Respiratory Drug Delivery
- Trauma Management and Diagnosis
- Combustion and Detonation Processes
- Neonatal and fetal brain pathology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular and Diving-Related Complications
- Gastroesophageal reflux and treatments
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Neonatal and Maternal Infections
- Healthcare Technology and Patient Monitoring
- Intensive Care Unit Cognitive Disorders
- Infant Nutrition and Health
- Parasitic Infections and Diagnostics
- Coccidia and coccidiosis research
- Refrigeration and Air Conditioning Technologies
- Adrenal Hormones and Disorders
University of Minnesota
2011-2024
United States Food and Drug Administration
2023-2024
Center for Food Safety and Applied Nutrition
2023-2024
American Academy of Pediatrics
2018
Children’s Minnesota - St. Paul Hospital
2007-2017
RELX Group (Netherlands)
2017
Children's Minnesota
2017
University of Minnesota System
2014-2015
Boston Children's Hospital
1987-2008
University of Minnesota Medical Center
2008
Background. Infants developing bronchopulmonary dysplasia (BPD) show decreased cortisol response to adrenocorticotropic hormone. A pilot study of low-dose hydrocortisone therapy for prophylaxis early adrenal insufficiency showed improved survival without BPD at 36 weeks’ postmenstrual age, particularly in infants exposed histologic chorioamnionitis. Methods. Mechanically ventilated with birth weights 500 999 g were enrolled into this multicenter, randomized, masked trial between 12 and 48...
Objective To evaluate the effect of prolonged partial liquid ventilation with perflubron (partial ventilation), using conventional and high-frequency ventilatory techniques, on gas exchange, hemodynamics, lung pathology in an animal model injury. Design Prospective, randomized, controlled study. Setting Animal laboratory Infant Pulmonary Research Center, Children's Health Care-St. Paul. Subjects Thirty-six newborn piglets. Interventions We studied piglets injury induced by saline lavage....
BACKGROUND. Low cortisol concentrations in premature infants have been correlated with increased severity of illness, hypotension, mortality, and development bronchopulmonary dysplasia. A total 360 mechanically ventilated a birth weight 500 to 999 g were enrolled randomized, multicenter trial prophylaxis early adrenal insufficiency prevent Mortality dysplasia decreased the hydrocortisone-treated patients exposed chorioamnionitis. We now report outcomes at 18 22 months' corrected age....
Despite advances in care of critically ill neonates, extended mechanical ventilation and tracheostomy are sometimes required. Few studies focus on complications clinical outcomes. Our aim was to provide long-term outcomes for a cohort infants who required tracheostomy.This study is retrospective review 165 born between January 1, 2000 December 31, 2010 ventilator support. Children with complex congenital heart disease were excluded.Median gestational age 27 weeks (range 22-43), birth weight...
Ten neonates with intractable respiratory failure were treated high-frequency jet ventilation (HFJV). Nine had progressive pulmonary air leaks either bronchopleural fistulas or interstitial emphysema as the primary cause of their failure. Following HFJV, x-ray film evidence decreased in seven nine neonates. Pao2/FIO2 increased eight ten patients (P <. 05), and Paco2 values < .01). Five survived. Three six exposed to HFJV for more than 20 hours developed significant tracheal...
We compared the effects of surfactant and partial liquid ventilation (PLV), impact administration order, on oxygenation, respiratory system compliance (Crs), hemodynamics, lung pathology in an animal injury model. studied four groups: alone (S; n = 8); (PLV-only; followed by (S-PLV; (PLV-S; 8). Following treatments, all animals had improved oxygenation index (OI) Crs. Animals PLV groups showed continued improvement over 2 h (% change OI: PLV-S − 83% versus S 47%, p < 0.05; % Crs: S-PLV 73%...
We measured the pulmonary mechanics of 23 mechanically ventilated neonates. Airway pressures, inspiratory and expiratory flows were simultaneously measured. Values for respiratory system then derived from these data by using a personal computer special software program. Volume-pressure (V-P) loops compliance values determined representative mechanical breaths. Twelve infants had normal-appearing V-P loops. Eleven characteristic lung overdistention, showing decreasing changes in volume with...
During a 4-year period, 34 neonates were treated with high-frequency jet ventilation (HFJV) using two different HFJV systems. Twenty-three of the had severe pulmonary air leaks, five congenital left-sided diaphragmatic hernias, and six end-stage respiratory failure without leaks. The systems performed similarly in all pathologic conditions. Following HFJV, arterial blood gas values improved 28 patients (82%). Eleven (32%) ultimately survived. Of 23 17 (74%) improved, nine (39%) One infant...
We compared the tracheobronchial histopathology seen after conventional mechanical ventilation (CMV) and high-frequency jet (HFJV) in 44 adult cats. Two different HFJV humidity systems were examined: one used entrained mist alone, other infused 3 ml/kgh of 0.45% NaCl directly into stream. produced more tracheal damage than CMV. This occurred at endotracheal tube tip. The pattern injury was acute inflammation, with erosion, necrosis, infiltration polymorphonuclear (PMN) leukocytes. system...
Regulatory methods for detection of the foodborne protozoan parasite Cyclospora cayetanensis must be specific and sensitive. To that end, we designed evaluated (in a single laboratory validation) novel improved primer/probe combination (Mit1C) real-time PCR C. in produce. The newly developed targets conserved region mitochondrial genome varies other closely related organisms. was both silico using several kits polymerases against an inclusivity/exclusivity panel comprised variety oocysts, as...
The effect of progressive increases in ventilator rate on delivered tidal and minute volumes, the changing peak inspiratory pressure (Pmax), positive end-expiratory (PEEP), inspiration to expiration (I:E) ratio at different rates were examined. Five continuous-flow, time-cycled, pressure-preset infant ventilators studied using a pneumotachograph, an airway monitor, lung simulator. As increased from 10 150 breaths per minute, volume stayed constant until 25 30 minute; then progressively...
Abstract We examined the effects of regular bedside testing pulmonary mechanics (PM) on outcome 468 acutely ill, mechanically ventilated neonates. During first two 18‐month study periods, 217 infants were without assistance PM measurements. second period, 251 with at least daily Using data obtained from tests, we adjusted infants' ventilators to maintain tidal volume, inspiratory time, and pressure‐volume loops within predetermined limits. With exception measurements, given limitations...