Abstract Chiral resolution of baclofen, bupropion, and etodolac profens was obtained with amylose derivatized chiral reversed stationary phase (carbamate groups). The eluent used for bupropion MeOH–water (20:80, v /v) baclofen water–methanol (95:5, /v). run rates, finding wavelength temperature, were 1.0 mL/min, 220 nm 27 ± 1 °C all the eluents. magnitude retardation factors S‐ R‐enantiomers 1.37, 2.62, 2.25, 3.25, 1.8, 3.0. magnitudes separation 1.90, 1.44, 1.67 2.77, 2.35, 2.04. Limits...

Many pollutants are present at trace level in our environment, which beyond the scope of detection by advance instruments too. Therefore, there is urgent need to develop sample preparation methods determine concentrations even levels. Keeping this into consideration, many extraction techniques have been developed and applied for analysis organic environmental samples. This review presents sate-of-the-art The discussed headspace, liquid based extraction, supported liquid, homogeneous...

Ester hydrolysis is a common and important reaction in organic chemistry. It catalyzed by acid or base. This phenomenon becomes very interesting when it attains enantioselectivity. Its most example the enantioselective of S-naproxen ester. When R/S-naproxen ester performed, only takes part hydrolysis, but R-naproxen does not. Because this, R/S naproxen used to gain pharmaceutically biologically active S-naproxen. The data literature describe why possible, while that Furthermore, another...

Enantiomeric resolution and simulation studies of four enantiomers 5-bromo-3-ethyl-3-(4-nitrophenyl)-piperidine-2,6-dione on a Chiralpak IA column were presented.

It is a continuous chase of researchers to separate chiral racemates due their dominance in the pharmaceutical industry, agrochemicals, and food additives. There are many analytical techniques which have been used resolve one center racemates, but, little literature report scanty for resolution multiple stereogenic racemates. Therefore, this article efforts were made describe enantiomeric by different modalities chromatography. The various discussed high-performance liquid chromatography,...

Abstract Chiral high‐performance liquid chromatography (HPLC) separation and modeling of four stereomers DL‐leucine‐tryptophan DL‐dipeptide on AmyCoat‐RP column are described. The mobile phase applied was ammonium acetate (10 mM)‐methanol‐acetonitrile (50:5:45, v/v). flow rate the phases 0.8 mL/min with UV detection at 230 nm. values retention factors for LL‐, DD‐, DL‐, LD‐ were 2.25, 3.60, 5.00, 6.50, respectively. resolution 1.60, 1.39, 1.30 7.76, 8.05, 7.19. limits quantitation ranging...

Abstract New chiral high‐performance liquid chromatography (HPLC) method for the enantiomeric resolution of quinolones is developed and described. The column used was Chirobiotic T (150 × 4.6 mm, 5.0 μm). Three mobile phases were MeOH:ACN:Water:TEA (70:10:20:0.1%), (60:30:10:0.1%), (50:30:20:0.1%). flow rate 1.0 mL/min with UV detection at different wavelengths. values retention, resolution, separation factors ranged from 1.5 to 6.0, 1.80 2.25, 2.86 respectively. limit quantification 4.0 12...

In the field of chiral separation, elution order enantiomers is one most important phenomena. Although reversal enantiomeric rare, it has certain significance. determination optical purities, study this phenomenon helpful because favorable to elute minor impurity before major component. This mini review reports class drugs β-blockers. describes effects composition mobile phase, pH, and temperature on The efforts are also made discuss possible future perspectives elution.

Ionic liquids are a very important class of compounds due to their remarkable properties and wide range applications. On the other hand, capillary electrophoresis is also gaining importance in separation science because its fast speed inexpensive nature. The use ionic continuously. present review article describes applications electrophoresis. This general aspects electrophoresis, optimization separation, mechanism toxicity liquids, as well future perspectives, have been discussed. It was...

In regards to the Cannizzaro reaction and its peculiar mechanism, some researchers have presented a free radical mechanism for reaction, while others found that it is feasible through an ionic but actual has not been finalized yet. The given proof of both mechanisms their papers published. Actually, may occur depending on molecular structure different conditions which are yet be explained. Recently published describe occurs only in heterogeneous medium, homogeneous medium. We revealed no...

Around us, we have many chiral macromolecules such as protein, carbohydrate, nucleic acid, steroids, peptides and phospholipids. Hence, these compounds exist in enantiomeric forms know that only one of the is important to us another may or not be useful. Therefore, analysis has taken a unique place analytical chemistry. The separation by techniques very difficult so few papers were found literature, which been discussed this chapter. presented chapter describes macromolecule two i.e. high...