A5048721046- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Analytical Methods in Pharmaceuticals
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactions of Organic Compounds
- Synthesis of Organic Compounds
- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Neuroscience and Neuropharmacology Research
- Multicomponent Synthesis of Heterocycles
- Advanced Drug Delivery Systems
- Cancer therapeutics and mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Click Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Nephrotoxicity and Medicinal Plants
- Ocular Diseases and Behçet’s Syndrome
- Tannin, Tannase and Anticancer Activities
- Pharmacological Effects and Assays
- Synthesis of Tetrazole Derivatives
- Retinoids in leukemia and cellular processes
- Hormonal and reproductive studies
Baddi University of Emerging Sciences and Technologies
2011-2023
Uttaranchal University
2021
Shobhit University
2021
Jamia Hamdard
2010-2015
Hamdard University
2010-2014
National University of Computer and Emerging Sciences
2011
Based on the heterocyclic core of bendamustine, four series (4a–g, 5a–f, 8a–b and 9a–b) benzimidazole derivatives were designed synthesized starting from 4-(1H-benzo[d]imidazol-2-yl)-4-oxobutanehydrazide. In rational design target molecules, ring bendamustine was retained bis-(chloroethyl) amine group (mechlorethamine) substituted with several biologically active scaffolds such as oxadiazole, thiadiazole, triazolo-thiadiazines, in hope obtaining novel cytotoxic agents improved efficacy...
Liquid chromatography tandem mass (LC-MS/MS) is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because high sensitivity and selectivity, LC-MS/MS has been used pharmacokinetic studies, metabolites identification the plasma urine. This manuscript gives comprehensive analytical review, focusing on chromatographic separation approaches (column packing materials, column length mobile phase) as well different acquisition modes (SIM, MRM) glucocorticoids...
The perception of white skin as a standard beauty has led to significant consumer demand for whitening agent products, contributing the ongoing expansion cosmeceuticals market. In this market, hundreds businesses have created and introduced products. Skin refers process lightening complexion through artificial methods, including creams, lotions, soaps, injections. Among many uses care cosmetics are anti-oxidants, anti-inflammatory, anti-microbial, antiseptic properties. Vitamins also...
Transdermal patches are a novel drug delivery system intended to deliver medication across the skin for systemic absorption. have several benefits, including controlled and sustained release of drug, improved patient compliance, avoidance first-pass metabolism, which is typical with oral administration. The patch usually made up backing layer, reservoir or matrix, an adhesive layer that provides attachment skin. Release achieved through layers by diffusion, formulation properties dictating...
Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H- 1,2,4-triazol (3a-3f) andN-[5-(4-substituted)-1H-1,2,3-triazol-1-yl]isonicotinamide derivatives (5a-5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 2. The antibacterial antifungal activities newly compounds tested the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus Bacillus...
Pain is an unpleasant and subjective sensation that results from a harmful sensorial stimulation, which alerts the body about current or potential damage to its tissues organs. Fever complex physiological response triggered by infections aseptic stimuli. Elevation in temperature occurs when concentration of prostaglandin E(2) (PGE(2)) increases within parts brain. Triazole derivatives have been found possess various pharmacological biological activities, such as, anti-inflammatory,...
Diabetes mellitus is one of the fastest-growing metabolic disorders. Worldwide, out 10 people suffer from diabetes mellitus. In this manuscript, we establish antidiabetic potential previously synthesized pyridazine derivatives using in silico and vitro experiments. Molecular docking studies with pullulanase Amy12, isomaltase, alpha-amylase receptors revealed that Molecules 45, 46, 29 showed good interaction scores. ADMET analysis top three docked (45, 29) lesser solubility poor distribution...
Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds screened for antihypertensive activities non-invasive method using Tail Cuff method. All the test showed significant activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited activity more than reference standard drugs.
Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons.The final compounds (4a-i) screened for antihypertensive activities non-invasive method using Tail Cuff method.The 4e and 4i showed appreciable activity.
The title compound, 1-(1H-benzimidazol-2-yl)-3-[5-(trichloromethyl)-1,3,4-oxadiazol-2-yl]propan-1-one (2) was synthesized successfully from 4-(1H-benzimidazol-2-yl)-4-oxobutanehydrazide (1) under microwave irradiation in good yield by reacting with trichloroacetic acid, and the structure of compound confirmed on basis IR, 1H-NMR, 13C-NMR, MS CHN analyses results.
Background: Multi Drug Resistance (MDR) is one of the main hindrances in successful treatment cancer by natural agents. Most anticancer drugs are effluxed P-glycoprotein resulting failure chemotherapy. Phenothiazines and related first investigated for reversal MDR. Exhaustive studies have been done to develop potent phenothiazines analogues MDR activity. Keywords: Phenothiazines, p-glycoprotein, MDR, chemotherapy, anti cancer, SAR.
During the manufacture of bulk drug midazolam various impurities arised that can be related products or degradation products. Structures eight arise during were proposed. In present work, synthesis these and their characterization by different spectroscopic techniques have been done. HPLC method was developed for separation from drug. The separates its impurities/degradation within a run time 45 min.