A5062346299- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vascular Anomalies and Treatments
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Liver Disease and Transplantation
- Cardiac Valve Diseases and Treatments
- Medical Imaging and Pathology Studies
- Hepatitis Viruses Studies and Epidemiology
- Cardiovascular and Diving-Related Complications
- Vascular Procedures and Complications
- Pulmonary Hypertension Research and Treatments
- Trauma Management and Diagnosis
- Pleural and Pulmonary Diseases
- Coronary Artery Anomalies
- Genetic factors in colorectal cancer
- Dermatological and COVID-19 studies
- Ultrasound in Clinical Applications
- Cell death mechanisms and regulation
- Intraperitoneal and Appendiceal Malignancies
- Medical research and treatments
- Radiation Detection and Scintillator Technologies
National Academy of Medical Sciences
2023
Central Electronics Engineering Research Institute
2023
Armed Forces Medical College
2019-2022
Command Hospital
2022
CARE Hospitals
2020-2021
Patan Hospital
2013-2019
Eastern Command Hospital
2017
Patan Academy of Health Sciences
2013-2016
Defence Institute of High Altitude Research
2015
Public Health England
2013
ABSTRACT mtCLIC/CLIC4 (referred to here as mtCLIC) is a p53- and tumor necrosis factor alpha-regulated cytoplasmic mitochondrial protein that belongs the CLIC family of intracellular chloride channels. mtCLIC associates with inner membrane. Dual regulation by two stress response pathways suggested this channel might contribute cellular cytotoxic stimuli. DNA damage or overexpression p53 upregulates induces apoptosis. Overexpression transient transfection reduces membrane potential, releases...
<h2>Summary</h2><h3>Background</h3> Because treatment with third-generation cephalosporins is associated slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin rapid fever clearance low burden, we postulated that would be superior to cephalosporin ceftriaxone in treating fever. <h3>Methods</h3> We did an open-label, randomised, controlled, superiority trial at two hospitals Kathmandu valley, Nepal. Eligible participants were children...
Background Fluoroquinolones are the most commonly used group of antimicrobials for treatment enteric fever, but no direct comparison between two fluoroquinolones has been performed in a large randomised trial. An open-label randomized trial was conducted to investigate whether gatifloxacin is more effective than ofloxacin uncomplicated fever caused by nalidixic acid-resistant Salmonella enterica serovars Typhi and Paratyphi A. Methodology Principal Findings Adults children clinically...
Abstract We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted tertiary referral (Patan Hospital) Kathmandu, Nepal. The CNS were confirmed cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients recruited for etiological diagnosis was established 38% (n = 33). bacterial identified Neisseria meningitidis 6); Streptococcus...
Background In many rural areas at risk for enteric fever, there are few data on Salmonella enterica serotypes Typhi (S. Typhi) and Paratyphi Paratyphi) incidence, due to limited laboratory capacity microbiologic culture. Here, we describe an approach that permits recovery of the causative agents fever in such settings. This involves use electricity-free incubator based upon phase-change materials. We compared this against conventional blood culture detection typhoidal Salmonella....
An increase in the number of cases Salmonella enterica serotype Goldcoast infection was observed England during September 2013. A total 38 were reported, with symptom onset dates between 21 June and 6 October Epidemiological, environmental, microbiological food chain evidence all support conclusion that this outbreak associated eating whelks processed by same factory. Whelks are a novel vehicle should be considered when investigating future outbreaks.
Bronchoscopic device closure plays a significant role in the nonsurgical management of bronchopleural fistulae (BPF). Herein, we describe our 10-year experience postoperative BPF using various modalities. This is largest series bronchoscopic being reported from India.This was retrospective analysis data patients who underwent with techniques for BPF. In total, 11 (six males and five females) mean age (±standard deviation) 42.72 ± 14.40 years BPFs were treated interventions closure. We used...
The Food Standards Agency for the United Kingdom has published its findings of a survey salmonella contamination in eggs produced outside UK and on retail sale England
This research focuses on the use of Artificial Neural Network (ANN) for prediction microhardness friction stir processed aluminium based metal matrix composite (AA6061+Al2O3). Different specimens were obtained by using rotating speeds 1100, 1210, 1320 and 1430 rpm travelling 36, 48, 60, 72 mm/min. The value (HV) surface each samples was measured data collected from used as learning ANN. Higher rotational speed lower transversal resulted in higher hardness since processing at tool causes high...
Introduction Appendicular mass is one of the most common complications following acute appendicitis and seen in 2-6% patients. The treatment appendicular controversial with three general approaches. aim this study to evaluate outcome conservative approach.Material & Methods A retrospective analysis patients managed from 1st January 31st December 2014 was carried out NMCTH, Biratnagar. total 173 diagnosis admitted emergency OPD our hospital were studied. All age groups both sex...
introductionPrimary tracheal malignancies are very rare tumours and their incidence is approximately 0.1 in every 100,000 persons per year. 1 The differential diagnosis of a mass comprises certain malignant (squamous cell carcinoma, adenoid cystic carcinoid) as well benign tumours, such papilloma, haemangioma, hamartoma, neurilemmomas neurofibromas. 2 Squamous carcinoma the most common cause intra-tracheal followed by together these account for about two-thirds adult primary tumours. 3Benign...
Acute pulmonary embolism with floating right intra-ventricular thrombus is a rare phenomena associated poor prognosis. Here, we are presenting case of 35-year-young male no co-morbid illness diagnosed to have ventricular bilateral embolism, which was managed successfully thrombolytic therapy.
Background :Laparoscopic cholecystectomy (LC) is a treatment of choice for symptomatic gall stone disease and commonly done all over the country in general surgical practice. The aim this study to show results LC our medical college.Material Methods: A retrospective analysis patients underwent laparoscopic from July 2015 September 2016 was carried out NMCTH, Biratnagar. total 391 admitted through OPD Hospital were studied. All age groups both sex included.Results: Out with cholelithiasis,...
Background: Transcatheter device closure of ostium secundum atrial septal defect is a safe & effective intervention in older children, usually done under transesophageal echocardiography guidance. However, the procedure transthoracic guidance, especially smaller only at few centers, data which scarce.
 Methods: A prospective study was undertaken to assess mid-term efficacy and outcome transcatheter echocardiographic children <15 Kg.
 Results: Eighty three with were included...
Congenital lobar emphysema is a rare disorder of unknown aetiology that may present diagnostic challenge.We report two cases congenital in paediatric age group who were initially treated as pleuro-pulmonary tuberculosis and recurrent pneumonias, respectively.Eventually they diagnosed following chest radiography, computed tomography bronchoscopic evaluation.