The present study compares the apical microleakage of three different root-end filling materials in which retrograde cavity is prepared by two burs.Eighty extracted single rooted maxillary and mandibular premolars were taken. Root canal treatment was completed. Apical 3 mm all teeth resected with diamond disk. tooth divided into four groups subgroups for each group containing 10 (N = 10) as: Group IA (Negative Control IB (Positive Control); IIA IIB: Prepared round carbide bur respectively,...

Progressive cognitive decline in Alzheimer's disease could either be caused by a spreading molecular pathology or an initially focal that causes aberrant neuronal activity larger network. To distinguish between these possibilities, we generated mouse model with expression of mutant human amyloid precursor protein (APP) only hippocampal CA3 cells. We found performance hippocampus-dependent memory task was impaired young adult and aged mice. In both age groups, then recorded from the CA1...

The emergence of new variants the novel coronavirus SARS-CoV-2 with increased infectivity, superior virulence, high transmissibility, and unmatched immune escape has demonstrated adaptability evolutionary fitness virus. subject relative order binding affinity human ACE2 (hACE2) receptor is hotly debated its resolution implications for drug design development. In this work, we have investigated energetics domain (RBD) concern (VOCs): Beta (B.1.351), Delta (B.1.617.2), Omicron (B.1.1.529),...

Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Poor glycemic control leads to diabetic complications. Hyperuricemia has been reported with increased risk of renal insufficiency. The aim this study was evaluate the relationship between serum uric acid concentration, degree urinary albumin excretion (UAE) and glycated hemoglobin (HbA1c) Type 2 DM (T2DM) patients.Serum concentrations, urine microalbumin, HbA1c...

Objectives: The objective of the study was to assess differences iodine status as measured by urinary excretion (UIE) between cases hypothyroidism and healthy controls. Materials Methods: conducted in with subclinical (n = 58) overt 41) compared age- sex-matched euthyroid controls 52) attending Universal College Medical Sciences Teaching Hospital, Bhairahawa, Nepal. Serum free triiodothyronine (fT3), thyroxine (fT4), thyroid-stimulating hormone (TSH) were estimated competitive ELISA sandwich...

Introduction: In developing countries like Nepal, iron deficiency anemia (IDA) is one of the major concern. The high rate incidence has been related to insufficient intake, accompanied by chronic intestinal blood loss due parasitic and malarial infections. Therefore, a study was conducted evaluate prevalence IDA in anemic patients Universal College Medical Sciences-Teaching Hospital (UCMS-TH), South Western region, Nepal.
 Material Method It hospital based cross sectional comprised 100...

The study was carried out to optimize the phenotypic method characterize sickle cell trait (SCT), anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT SCA were further evaluated by genotypic employing amplification refractory mutation system (ARMS PCR). Moreover, Glucose 6 phosphate dehydrogenase (G6PD) estimated in those hemoglobinopathy observe its prevalence. accurate reliable can play an important role reduction morbidity...

Amenorrhea is the absence of menstrual periods. It has multiple social consequences as it may leads to infertility. This case control study was conducted for determining association thyroid hormones with hyperprolactinemia in patient amenorrhea.We investigated 50 women diagnosed cases secondary amenorrhoea, who attended UCMS hospital, hormonal evaluations. Fifty two healthy were taken controls. The dysfunction and serum prolactin level reviewed controls.Mean found be significantly higher...

We sought to (1) determine the bleeding rates after primary percutaneous coronary intervention (PPCI) in our institution, where default strategy has been transradial (TR) access combination with unfractionated heparin (UFH) plus eptifibatide, and (2) compare these outcomes of patients treated bivalirudin HORIZONS-AMI.HORIZONS-AMI demonstrated that PPCI undertaken via transfemoral route, routine use was associated lower improved mortality compared UFH glycoprotein IIb/IIIa inhibitor...

Objective: The aim of this study was to determine the frequency type 2 diabetes, impaired fasting glucose (IFG) and tolerance (IGT) among patients visiting a tertiary level teaching hospital in south-western Nepal. Material & Methods: This is retrospective conducted subjects (n=17082) who visited outpatient department Universal College Medical Sciences Teaching Hospital (UCMSTH), Bhairahawa, Nepal for their medical checkup. Data related age, sex, number blood concentration were collected...

INTRODUCTION: The cardiovascular disease (CVD) is associated with diabetes mellitus and dyslipidemia plays important role in CVD. This paper explores the frequency pattern of type 2 patients that compared healthy control. correlation glucose level lipid profile including Non-HDL/HDL TG/HDL has been projected this study.MATERIAL AND METHODS: case-control study includes 263 55 controls. diagnosis Diabetes was made according to World Health Organization (WHO) criteria for obtained by National...

Diabetic retinopathy (DR) is one of the leading causes preventable blindness in low and middle income countries. In Nepal, there are less studies regarding DR they too limited around Kathmandu valley. This study was done to assess visual morbidity patients with at a peripheral tertiary eye care center Nepal.This prospective, hospital based, cross-sectional which all consecutive cases were evaluated. classified according Early Treatment Retinopathy Study Research Group - report no. 10 Table...

INTRODUCTION: In South Asian Region, the prevalence of anemia among pregnant women has been estimated to be 75% which is highest in world. Hence, this study was drafted evaluate western part NepalMATERIALS AND METHODS: It a hospital based cross-sectional study. A total 200 ladies aged 15-45 years giving consent for were included and their detailed medical history, clinical examination lab investigations focusing on hematological parameters documented. Data entered excel sheet analysed by...

INTRODUCTION: There is lack of data related to smoking and alcohol intake status with concomitant health academic problem medical students. Hence this study undertaken compare habits among students from second fourth year their education. MATERIAL AND METHODS: A self-directed questionnaire on were distributed who willing participate in study. All participants told fill questions regarding past current history anonymously. RESULTS: Out 300 comprising male 201 (67%) female 99 (33 %) students,...

Abstract Objectives The study was carried out with the aim to find frequency of Glucose 6 phosphate dehydrogenase (G6PD) deficiency among patients attending hospital and rationalize qualitative methemoglobin reduction test in reference quantitative spectrophotometric assay. Timely screening for G6PD appropriate method can play an important role preventing hemolytic crisis that arises from therapeutic use oxidative drugs like primaquine. Result deficient cases 3% by both employed tests. mean...

INTRODUCTIONDiabetes mellitus is defined as the increase in blood glucose levels associated with a relative insulin deficiency, resistance or both. Datura stramonium commonly known Jimson weed belongs to family Solanaceae containing different types of alkaloids, saponins, tannins, steroids, flavonoids, phenols and glycosides. MATERIAL AND METHODSExtraction was done by maceration process using ethanol solvent. Swiss albino mice 20-35 gram were taken study animal. Diabetes induced Alloxan 20...