A5073354239- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmacology and Obesity Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medication Adherence and Compliance
- Colorectal Cancer Treatments and Studies
- Muscle metabolism and nutrition
- Inhalation and Respiratory Drug Delivery
- Chronic Disease Management Strategies
- ECG Monitoring and Analysis
- Retinal Imaging and Analysis
- Natural Antidiabetic Agents Studies
- Pharmacy and Medical Practices
- Cardiovascular and Diving-Related Complications
- Mobile Health and mHealth Applications
- Chronic Kidney Disease and Diabetes
- Potassium and Related Disorders
Örebro University
2016-2025
European School of Molecular Medicine
2024
Örebro University Hospital
2008-2023
Karolinska Institutet
2023
Karlstad Central Hospital
2008-2014
University of New Orleans
2014
Indianapolis Zoo
2014
Manitoba Beekeepers' Association
2014
Karlstad University
2012
Trelleborg (Sweden)
2006-2009
The effect on body composition of liraglutide, a once-daily human glucagon-like peptide-1 analogue, as monotherapy or added to metformin was examined in patients with type 2 diabetes (T2D).These were randomized, double-blind, parallel-group trials 26 [Liraglutide Effect and Action Diabetes-2 (LEAD-2)] 52 weeks (LEAD-3). Patients T2D, aged 18-80 years, mass index (BMI) < =40 kg/m(2) (LEAD-2), =45 (LEAD-3) HbA1c 7.0-11.0% included. randomized liraglutide 1.8, 1.2 0.6 mg/day, placebo...
<b>Objective</b> To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes. <b>Design </b>Observational study. <b>Setting </b>Swedish National Diabetes Register, Sweden 2005-12. <b>Participants</b> 18 168 diabetes, 2441 using therapy 15 727 multiple daily injections. <b>Main outcome measures</b> Cox regression analysis was used to estimate hazard ratios for outcomes,...
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
Comparing the performance of different continuous glucose monitoring (CGM) systems is challenging due to lack comprehensive guidelines for clinical study design. In particular, absence concise requirements distribution comparator (reference) blood (BG) concentrations and their rate change (RoC) that are used evaluate CGM performance, impairs comparability. For this article, several experts in field testing have collaborated propose characteristics measurements should be collected during...
Insulin degludec (IDeg) is a basal insulin that forms soluble multihexamers after subcutaneous injection, resulting in an ultra-long action profile. We assessed the efficacy and safety of IDeg formulations administered once daily combination with mealtime aspart people type 1 diabetes.In this 16-week, randomized, open-label trial, participants (mean: 45.8 years old, A1C 8.4%, fasting plasma glucose [FPG] 9.9 mmol/L, BMI 26.9 kg/m(2)) received injections IDeg(A) (600 μmol/L; n = 59), IDeg(B)...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
This study, one of the first to address issues pulmonary insulin delivery in smokers, compared pharmacokinetics inhaled delivered via AERx Diabetes Management System (iDMS) nondiabetic cigarette smokers and nonsmokers.In this randomized two-period crossover efficacy safety trial 27 16 nonsmokers (18 men/25 women, mean age 28 years, BMI 23.0 kg/m(2)), subjects received single doses (33.8 IU) following overnight fasting on consecutive dosing days. On day, smoked three cigarettes immediately...
Hypoglycaemia remains a major barrier preventing optimal glycaemic control in Type 1 diabetes due to the limitations of conventional insulin preparations. We investigated whether basal-bolus therapy with detemir (detemir), new soluble basal analogue, was more effective reducing risk hypoglycaemia compared NPH (NPH).In this multinational, open-label, cross-over trial, 130 individuals received and twice daily randomized order combination premeal aspart (IAsp) during two 16-week treatment...
Abstract Aims/hypothesis The risk of complications and medical consequences type 2 diabetes are well known. Hospital costs have been identified as a key driver total in studies the economic burden diabetes. Less evidence has generated on impact individual diabetic overall societal burden. objective this study was to analyse hospital-based healthcare (inpatient outpatient care) work absence related macrovascular microvascular Sweden 2016. Methods Data for 2016 were retrieved from Swedish...
To evaluate the real-world performance of MiniMed 670G system in Europe, individuals with diabetes.Data uploaded from October 2018 to July 2020 by living Europe were aggregated and retrospectively analysed. The mean glucose management indicator (GMI), percentage time spent within (TIR), below (TBR) above (TAR) glycaemic ranges, use insulin consumed users 10 or more days sensor data after initial Auto Mode start determined. Another analysis based on suboptimally (GMI > 8.0%) well-controlled <...
There are few studies providing a more comprehensive picture of advanced hybrid closed-loop (AHCL) systems in clinical practice. The aim was to evaluate the effects AHCL systems, Tandem
Real-world evidence has demonstrated improved glycemic control and insulin management following introduction of smart pens in a Swedish type 1 diabetes (T1D) population. To understand the implications for healthcare costs expected health outcomes, this analysis evaluated long-term cost-effectiveness introducing to standard-of-care T1D treatment (standard care) from societal perspective. Clinical outcomes (in 2018 krona, SEK) were projected over patients' lifetimes using IQVIA CORE Diabetes...
Hybrid closed-loop (HCL) systems combine continuous glucose monitoring with subcutaneous insulin infusion (CSII) to continuously self-adjust basal delivery. Relative CSII, HCL improves glycemic control and reduces the risk of hypoglycemia but has higher acquisition costs. The aim this analysis was assess cost-effectiveness MiniMed™ 670G system versus CSII in people type 1 diabetes (T1D) Sweden.Cost-effectiveness analysis, from a societal perspective, performed over patient lifetimes using...
Metrics derived from continuous glucose monitoring (CGM) systems are often discordant between systems. A major cause is that CGM not standardized; they use various algorithms and calibration methods, leading to readings across This discordance can be addressed by standardizing performance assessments: If manufacturers aim their at the same target, then will align standardization should include comparator device, sample origin, study procedures. With better aligned readings, CGM-derived...