A5069956721- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Healthcare during COVID-19 Pandemic
- Adrenal and Paraganglionic Tumors
- Youth, Drugs, and Violence
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Selenium in Biological Systems
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Health and Lifestyle Studies
- Thyroid Cancer Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Folate and B Vitamins Research
- Neuroendocrine Tumor Research Advances
- Healthcare Regulation
- Neurological and metabolic disorders
- Neuroblastoma Research and Treatments
- Muscle and Compartmental Disorders
- Metabolism, Diabetes, and Cancer
Universidade do Porto
2012-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2023
Hospital de São João
2012-2023
Direção Geral do Património Cultural
2021
Hospital Geral de Fortaleza
2021
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2018
University of Southern Denmark
2018
Association for Innovation and Biomedical Research on Light and Image
2018
Vall d'Hebron Institut de Recerca
2018
Diabetes Australia
2012
The primary objective of this study was to assess whether the topical administration two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For purpose, adults aged between 45 75 years a diabetes duration ≥5 an Early Treatment Diabetic Retinopathy Study (ETDRS) level ≤35 were randomly assigned one three arms: placebo, somatostatin, brimonidine. outcome change implicit time (IT) assessed by multifocal...
The association between selenium and inflammation the relevance of selenoproteins in follicular thyroid cell physiology have pointed to a putative role pathogenesis autoimmune diseases.The aim this study was evaluate promoter variation SEPS1, selenoprotein S gene, risk for developing Hashimoto's thyroiditis (HT).A case-control performed assess genetic SEPS1 gene (SEPS1 -105G/A single-nucleotide polymorphism, rs28665122) HT.The conducted north Portugal, Porto, period 2007-2013.A total 997...
Apesar da clássica Tripartição das funções do Estado, concebida por Montesquieu, restringir a jurisdição, típica Poder Judiciário, ao “dizer o direito”; tal poder tem inovado executar políticas públicas judiciárias, visando incentivar os demais Poderes promoverem com efetividade incremental, como parece ser caso Programa RegularizAÇÃO. Nesse contexto, analisa-se essa atuação atípica Tribunal de Justiça Estado Goiás, meio Corregedoria-Geral no contexto conceito nudges.
Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) represent two strategies of intensive therapy, obtaining a strict metabolic control. The importance such rigorous control in reducing the frequency severity diabetes long-term complications was highlighted by Diabetes Control Complication Trial (DCCT).To review experience use ISCI at Hospital São João, comparing it with therapeutic modality MID, regarding control, weight body mass index (BMI),...
Aim The prevalence of thyroid nodules and the risk cancer in patients with Graves’ disease is uncertain. We aimed to evaluate disease. Methods Retrospective observational study adult subjects Graves' (positive autoantibodies thyrotropin receptor antibodies (TRAbs)) between 2017 2021 at our center was done. evaluated this population characterized predictive factors for malignancy using linear logistic regression models. Results a total 539 during median follow-up 3.3 years (25th–75th...
Background Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is most common leading form in women. Cytokines are key regulators immune responses; therefore, genetic variants at cytokine-encoding genes potential risk factors for AITD. Methods Polymorphisms IL6-174 G/C...
To understand whether thyroid cells can be directly infected by the SARS-CoV-2 virus and to establish a putative correlation with expression of host entry machinery: ACE-2, TMPRSS2, furin.We assessed presence at gene level RT-PCR, viral RNA transcripts localization in situ hybridization, detecting proteins immunohistochemistry for nucleocapsid spike proteins. Furthermore, we also described immunoexpression key factors COVID-19 samples.We performed RT-PCR all autopsy specimens detected genome...
Abstract Background/ objective To evaluate the association of CGM parameters and HbA1c with diabetes complications in patients Type 1 Diabetes (T1D). Methods Patients T1D using system Freestyle Libre were included this analysis. The CGM-metrics (any complication, microvascular complications, or macrovascular complications) was assessed logistic regression unadjusted adjusted for age, sex, duration (model 1), further hypertension dyslipidemia 2). Results One hundred sixty-one included. mean...
Background: Several single-nucleotide polymorphisms (SNPs) are known to increase the risk of Hashimoto's thyroiditis (HT); such SNPs reside in thyroid-specific genes or related autoimmunity, inflammation, and/or cellular defense stress. The transcription factor Nrf2, encoded by NFE2L2, is a master regulator antioxidant response. This study aimed evaluate impact genetic variation NFE2L2 on developing HT. Methods: In case-control candidate gene association study, functional promoter...
Previous trials show that selenium could be a very useful tool in the control and treatment of autoimmune thyroid diseases. In this cross-sectional study, through survey, we aim to evaluate Portuguese endocrinologists' perception pattern prescription supplements these diseases verify its agreement with current guidelines.The endocrinologists registered Medical Association were sent an email web-based questionnaire, regarding their knowledge use pathology.A total 105 physicians (33% total)...
Exercise is an important practice for control in type 1 diabetes (T1D). This study aims to assess de association between exercise and glycemic management people with T1D identify the main barriers T1D.We evaluated 95 treated insulin pump therapy. Participants answered a questionnaire about 1) habits, 2) usual adjustments food intake 3) exercise. Continuous glucose monitoring (CGM) was used evaluate time range (TIR), below (TBR) above (TAR) during last 60 days before evaluation. CGM data...
Hyperglycemia is associated with abnormalities of lipoproteins. The aim this study was to analyze, in patients Type 1 Diabetes (T1D), the association glycemic control lipid profile, focusing on variability and time range obtained from Continuous Glucose Monitoring (CGM).
A 43-year-old female with antiphospholipid syndrome and Graves' disease developed a cutaneous leukocytoclastic vasculitis associated antineutrophil cytoplasmic antibody (ANCA) against myeloperoxidase (MPO-ANCA) proteinase-3 (PR3-ANCA), whilst treated propylthiouracil (PTU). The skin lesions were progressively resolved after withdrawal of PTU treatment oral steroids. Patch testing at 1%, 5%, 10% in petrolatum was positive 48 h. Despite ANCA titers 1 year follow-up, the patient maintains...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
We aimed to characterize hypoglycaemia episodes and patients examined by a Pre-hospital Medical Emergency Unit (PH) in the Department (ED) of our hospital. identified 86 severe (PH: n 37; ED: 49; both: 12). Hypoglycaemia accounted for 4.7% all emergency calls attended PH (n 793) 0.11% ED 54,366). Among PH, 64.5% involved had type 2 diabetes 54.1% were not referred ED. Transportation patient was more likely (p = 0.014). evaluated 66.1% than 65 years old 81.4% diabetes. 66% insulin treated....
Adrenocorticotropic hormone (ACTH) ectopic production is a rare cause of Cushing syndrome (CS). The most commonly associated tumours are small-cell lung carcinoma along with bronchial and thymic carcinoids. To date, only 5 cases have been published in the literature featuring ACTH secretion from metastatic acinic cell (ACC) parotid gland. We hereby describe very uncommon case CS (ECS) unveiling ACC.A 46-year-old man hypertension dyslipidemia diagnosed 4-months before, as well new-onset...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Hashimoto's thyroiditis (HT) is associated with high cardiovascular risk. Thyroid volume has a notable dispersion of values in these patients. This study aims to clarify the association between thyroid antibodies, morphology, insulin resistance, and lipid profile patients HT. Cross-sectional that includes 409 subjects diagnosed We assessed function, markers autoimmunity, also evaluated ultrasound studied correlation all factors. Among population, 9.8% were male, mean age was 56.4 ± 17.4...
Abstract Disclosure: C. Neves: None. J. L. Pereira: O. Sokhatska: Queirós: Delgado: Background: Autoimmune thyroiditis is one of the most common organ specific autoimmune disorders. Several studies suggest that patients with thyroid may have an increased cardiovascular risk even among those normal function. Our objective was to evaluate factors in according body weight. Methods: We evaluated followed outpatient clinic. anthropometric parameters, glycemic profile, lipid, homocysteine, folic...