A5086792638- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Thyroid Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Bone Metabolism and Diseases
- Cytokine Signaling Pathways and Interactions
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Kruppel-like factors research
- Estrogen and related hormone effects
- Animal Virus Infections Studies
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Chronic Lymphocytic Leukemia Research
- TGF-β signaling in diseases
- Selenium in Biological Systems
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
University of Lausanne
2016-2024
University of Patras
2007-2016
National and Kapodistrian University of Athens
2007
University of Chicago
2007
Alberta Children's Hospital
2007
Royal Manchester Children's Hospital
2007
Hospital Universitari Germans Trias i Pujol
2007
University of Campania "Luigi Vanvitelli"
2007
General University Hospital of Patras
2005-2006
Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver adipose tissue. Brown tissue (BAT) responsible for cold-induced thermogenesis rodents. The role FGF21 BAT biology has not been investigated. In present study, wild-type C57BL/6J mice as well brown adipocyte cell line were used to explore potential cold exposure β3-adrenergic stimulation BAT. Our results demonstrate that...
Obesity is a major health concern worldwide which associated with increased risk of chronic diseases such as metabolic syndrome, cardiovascular disease and cancer. The elucidation the molecular mechanisms involved in adipogenesis obesogenesis essential importance it could lead to identification novel biomarkers therapeutic targets for development anti-obesity drugs. MicroRNAs (miRNAs) have been shown play regulatory roles several biological processes. They become growing research field...
A primary goal of bone research is to understand the mechanism(s) by which mechanical forces dictate cellular and metabolic activities osteoblasts, bone-forming cells. Several studies indicate that osteblastic cells respond physical loading transducing signals alter gene expression patterns. Accumulated data have documented fundamental role osteoblast-specific transcription factor Cbfa1 (core-binding factor) in osteoblast differentiation function. Here, we demonstrate low level deformation...
Obesity is characterized by chronic oxidative stress. Fibroblast growth factor 21 (FGF21) has recently been identified as a novel hormone that regulates metabolism. NFE2-related 2 (Nrf2) transcription orchestrates the expression of battery antioxidant and detoxification genes under both basal stress conditions. The current study investigated role Nrf2 in mouse model long-term high-fat diet (HFD)-induced obesity its crosstalk to FGF21 this process.Wild-type (WT) knockout (Nrf2-KO) mice were...
// Adi Zheng 1 , * Nadja Chevalier Margot Calderoni Gilles Dubuis Olivier Dormond 2 Panos G. Ziros 3 Gerasimos P. Sykiotis and Christian Widmann Department of Physiology, University Lausanne, Switzerland Service Visceral Surgery, Lausanne Hospital, Endocrinology, Diabetology Metabolism, These authors contributed equally to this work Correspondence to: Widmann, email: Christian.Widmann@unil.ch Keywords: KEAP1; sorafenib; hepatocellular carcinoma; lenvatinib; Regorafenib Abbreviations: KEAP1:...
Urban sewage virological analysis may produce important information about the strains that cause clinical and subclinical infections in population, thus supporting epidemiological studies.In present study, a twenty one-month survey (November 2007 to July 2009) was conducted order evaluate presence of human adenoviruses (hAdV), hepatitis A viruses (HAV), E (HEV), Noroviruses (NoV), Polyomaviruses (hPyV) untreated samples collected from inlet Patras' municipal biological wastewater treatment...
The thyroid gland has a special relationship with oxidative stress. While generation of substances is part normal iodide metabolism during hormone synthesis, the must also defend itself against excessive oxidation in order to maintain function. Antioxidant and detoxification enzymes aid cells homeostasis by ameliorating insults, including exposure excess iodide, but factors that coordinate their expression cellular redox status are not known. antioxidant response system comprising...
The antioxidant transcription factor NFE2-related 2 (Nrf2), encoded by NFE2L2, has been implicated as mediator of thyroid cancer cell line resistance to proteasome inhibitors. However, the activity status Nrf2 pathway in human remains unknown.The aims this study were assessment papillary carcinoma (PTC) and investigation its role(s) transcriptional responses viability cells.We conducted retrospective immunohistochemical analyses PTC specimens, adjacent normal tissue, benign lesions; assays...
Introduction . The transcription factor NFE2-related 2 (Nrf2) is a central regulator of antioxidant and detoxification gene expression in response to electrophilic or oxidative stress. Nrf2 has recently been shown cross-talk with metabolic pathways, its deletion protected mice from high-fat-diet-(HFD-) induced obesity insulin resistance. This study aimed identify potential Nrf2-regulated genes interest by comparing profiles livers wild-type (WT) versus knockout (Nrf2-KO) after long-term HFD....
Two parallel gastroenteritis outbreaks occurred in an elementary school and a neighboring kindergarten Kilkis, Northern Greece 2012. The aim of the study was investigation these two as well their possible source.Two retrospective cohort studies were performed to identify mode vehicle transmission connection between them.Elementary populations 79.9% (119/149) 51.1% (23/45) respectively, participated study. Case definition satisfied by 65 pupils from 14 kindergarten. For school, 53 cases...
Objective In 2016, there were an estimated 56 870 new cases of thyroid cancer ( TC ) in the USA. Fine needle aspiration cytology FNAC is most safe, accurate and cost‐effective method for initial investigation nodules. limited by inability to diagnose malignancy follicular‐patterned lesions accurately and, as a result, 20%‐30% under are classified cytologically indeterminate, illustrating problem with current procedure. Raman spectroscopy has shown promising results detection many cancers;...
Abstract We document that GH controls osteoblast function by modulating the biological activity of osteospecific transcription factor Runx2. Evidence is provided for a physical interaction between Runx2 and Stat3β, which enhanced downregulates transcriptional properties this key osteogenic regulator. Introduction: Growth hormone (GH) signals to bone either through insulin-like growth factor-1 or directly influencing osteoblasts, bone-forming cells. This study aimed at exploring molecular...