A5003565002- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Fecal contamination and water quality
- Advanced biosensing and bioanalysis techniques
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Polyomavirus and related diseases
- Insect Utilization and Effects
- Hepatitis Viruses Studies and Epidemiology
- Microbial Community Ecology and Physiology
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- Insect and Arachnid Ecology and Behavior
- Child Nutrition and Water Access
- COVID-19 epidemiological studies
- Animal and Plant Science Education
- Viral Infections and Immunology Research
- Vibrio bacteria research studies
- Environmental DNA in Biodiversity Studies
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Water-Energy-Food Nexus Studies
Universitat de Barcelona
2014-2024
École Polytechnique Fédérale de Lausanne
2020-2024
European Food Safety Authority
2019-2020
Swedish University of Agricultural Sciences
2018-2020
Clínica Diagonal
2013-2014
Background: The effective reproductive number, Re, is a critical indicator to monitor disease dynamics, inform regional and national policies, estimate the effectiveness of interventions. It describes average number new infections caused by single infectious person through time. To date, Re estimates are based on clinical data such as observed cases, hospitalizations, and/or deaths. These temporarily biased when testing or reporting strategies change. Objectives: We show that dynamics severe...
Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, numbers may be underreported, whereas wastewater does not suffer from this limitation. Here we investigated how the dynamics of new infections estimated based on monitoring cases compare true incidence dynamics. We focused first pandemic wave in Switzerland (February April, 2020), when ranged up 26%. SARS-CoV-2 RNA loads...
Abstract The continuing emergence of SARS-CoV-2 variants concern and interest emphasizes the need for early detection epidemiological surveillance novel variants. We used genomic sequencing 122 wastewater samples from three locations in Switzerland to monitor local spread B.1.1.7 (Alpha), B.1.351 (Beta) P.1 (Gamma) at a population level. devised bioinformatics method named COJAC (Co-Occurrence adJusted Analysis Calling) that uses read pairs carrying multiple variant-specific signature...
Viral sewage metagenomics is a novel field of study used for surveillance, epidemiological studies, and evaluation waste water treatment efficiency. In raw human mixed with household, industrial drainage water, virus particles are, therefore, only found in low concentrations. This necessitates step sample concentration to allow sensitive detection. Additionally, viruses harbor large diversity both surface genome structures, which makes universal viral genomic extraction difficult. Current...
Abstract The emergence of SARS-CoV-2 mutants with altered transmissibility, virulence, or immunogenicity emphasizes the need for early detection and epidemiological surveillance genomic variants. Wastewater samples provide an opportunity to assess circulating viral lineages in community. We performed sequencing 122 wastewater from three locations Switzerland analyze B.1.1.7, B.1.351, P.1 variants on a population level. called variant-specific signature mutations monitored variant prevalence...
Novel foods could represent a sustainable alternative to traditional farming and conventional foodstuffs.Starting in 2018, Regulation (EU) 2283/2015 entered into force, laying down provisions for the approval of novel Europe, including insects.This Approved establishes requirements that enable Food Business Operators bring new EU market, while ensuring high levels food safety European consumers.The present risk profile tackles hazards one most promising insects, house cricket (Acheta...
Novel foods represent sustainable alternatives to traditional farming and conventional foodstuffs. The house cricket ( Acheta domesticus ) is considered as one of the most promising reared insects due their attractive nutritional profile lower feed conversion ratio compared other animals. However, putative health hazards associated with consumption crickets have previously not been investigated. present study assesses risks A. in closed systems controlled by implementation hazard analysis...
This was a detailed investigation of the seasonal occurrence, dynamics, removal and resistance human-associated genetic Bacteroidetes faecal markers (GeBaM) compared with ISO-based standard indicator bacteria (SFIB), human-specific viral one phage in raw treated wastewater municipal domestic origin. Characteristics selected activated sludge treatment plants (WWTPs) from Austria Germany were studied detail (WWTPs, n = 13, connected populations 3 to 49000 individuals), supported by...
Abstract Background The effective reproductive number, Re, is a critical indicator to monitor disease dynamics, inform regional and national policies, estimate the effectiveness of interventions. It describes average number new infections caused by single infectious person through time. To date, Re estimates are based on clinical data such as observed cases, hospitalizations, and/or deaths. These temporarily biased when testing or reporting strategies change. Objectives We show that dynamics...
Many different viruses are excreted by humans and animals frequently detected in fecal contaminated waters causing public health concerns. Classical bacterial indicator such as E. coli enterococci could fail to predict the risk for waterborne pathogens viruses. Moreover, presence levels of indicators do not always correlate with concentration viruses, especially when these present low concentrations. Our research group has proposed new viral methodologies determining pollution environmental...
Biological treatment of waterborne viruses, specifically grazing viruses by protists, can enhance microbial water quality while avoiding the production toxic byproducts and high energy costs. However, tangible applications are limited lack understanding underlying mechanisms. Here, we examined feeding behavior
BackgroundThroughout the COVID-19 pandemic, SARS-CoV-2 genetic variants of concern (VOCs) have repeatedly and independently arisen. VOCs are characterised by increased transmissibility, virulence or reduced neutralisation antibodies obtained from prior infection vaccination. Tracking introduction transmission relies on sequencing, typically whole genome sequencing clinical samples. Wastewater surveillance is increasingly used to track spread through approaches.AimHere, we adapt apply a...
In an approach combining microbiological culture methods with high-throughput sequencing, this study investigated the microbial communities (bacteria, moulds and yeasts) in Swedish-produced edible crickets (Acheta domesticus) reared a controlled environment. The effects of different feeds on loads populations were also studied. used third-generation offspring from wild-caught individuals Sweden, which are adapted to grow laboratory efficiency rinsing decrease load was evaluated not obtaining...
Wastewater-based epidemiology (WBE) has emerged as an effective tool for monitoring SARS-CoV-2 dynamics during the COVID-19 pandemic. Here, we add a spatial component to WBE and use it investigate spread in canton of Ticino onset pandemic Switzerland (end February 2020 beginning March 2020). is located at border Northern Italy, where large outbreak occurred 2020. Not surprisingly, was site first clinically confirmed case Switzerland. We retrospectively analyzed daily influent samples from...
Waterborne enteric viruses in lakes, especially at recreational water sites, may have a negative impact on human health. However, their fate and transport lakes are poorly understood. In this study, we propose coupled quality quantitative microbial risk assessment (QMRA) model to study the transport, infection of four common waterborne (adenovirus, enterovirus, norovirus rotavirus), using Lake Geneva as site. The measured virus load raw sewage entering lake was used source term simulations...
Acute infectious gastroenteritis is an important illness worldwide, especially on children, with viruses accounting for approximately 70% of the acute cases. A high number these cases have unknown etiological agent and rise next generation sequencing technologies has opened new opportunities viral pathogen detection discovery. Viral metagenomics in routine clinical settings potential to identify unexpected or novel variants pathogens that cause gastroenteritis. In this study, 124 samples...