A5002781178- SARS-CoV-2 detection and testing
- Photosynthetic Processes and Mechanisms
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Algal biology and biofuel production
- Advanced biosensing and bioanalysis techniques
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Light effects on plants
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- COVID-19 diagnosis using AI
- Photoreceptor and optogenetics research
- Advanced Thermodynamics and Statistical Mechanics
- Biosensors and Analytical Detection
- Plant nutrient uptake and metabolism
- Marine and coastal ecosystems
École Polytechnique Fédérale de Lausanne
2021-2023
University of Geneva
2015-2020
Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, numbers may be underreported, whereas wastewater does not suffer from this limitation. Here we investigated how the dynamics of new infections estimated based on monitoring cases compare true incidence dynamics. We focused first pandemic wave in Switzerland (February April, 2020), when ranged up 26%. SARS-CoV-2 RNA loads...
Abstract The continuing emergence of SARS-CoV-2 variants concern and interest emphasizes the need for early detection epidemiological surveillance novel variants. We used genomic sequencing 122 wastewater samples from three locations in Switzerland to monitor local spread B.1.1.7 (Alpha), B.1.351 (Beta) P.1 (Gamma) at a population level. devised bioinformatics method named COJAC (Co-Occurrence adJusted Analysis Calling) that uses read pairs carrying multiple variant-specific signature...
Abstract The emergence of SARS-CoV-2 mutants with altered transmissibility, virulence, or immunogenicity emphasizes the need for early detection and epidemiological surveillance genomic variants. Wastewater samples provide an opportunity to assess circulating viral lineages in community. We performed sequencing 122 wastewater from three locations Switzerland analyze B.1.1.7, B.1.351, P.1 variants on a population level. called variant-specific signature mutations monitored variant prevalence...
Differential phosphorylation of the Lhcb1 and Lhcb2 subunits light harvesting antenna plays contrasting roles in photosynthetic acclimation supercomplex assembly.
Protein phosphorylation plays important roles in short-term regulation of photosynthetic electron transfer, and during state transitions, the kinase STATE TRANSITION7 (STT7) Chlamydomonas reinhardtii phosphorylates components light-harvesting antenna complex II (LHCII). This reversible governs dynamic allocation a part LHCII to PSI or PSII, depending on light conditions metabolic demands, but counteracting phosphatase(s) remain unknown C. reinhardtii. Here we analyzed transitions mutants two...
Wastewater-based epidemiology (WBE) has emerged as an effective tool for monitoring SARS-CoV-2 dynamics during the COVID-19 pandemic. Here, we add a spatial component to WBE and use it investigate spread in canton of Ticino onset pandemic Switzerland (end February 2020 beginning March 2020). is located at border Northern Italy, where large outbreak occurred 2020. Not surprisingly, was site first clinically confirmed case Switzerland. We retrospectively analyzed daily influent samples from...
Virucidal efficacies of disinfectants are typically assessed by infectivity assay utilizing a single type host cell. Enteroviruses infect multiple cells via various entry routes, and each route may be impaired differently given disinfectant. Yet, it is unknown how the choice affects observed inactivation kinetics. Here, we evaluated kinetics echovirus 11 (E11) free chlorine, ultraviolet (UV) irradiation, heat, using three different (BGMK, RD, A549). Inactivation rates were independent cell...
Abstract Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, numbers may be underreported, whereas wastewater does not suffer from this limitation. Here we investigated how the dynamics of new infections estimated based on monitoring cases compare true incidence dynamics. We focused first pandemic wave in Switzerland (February April, 2020), when ranged up 26%. SARS-CoV-2...
ABSTRACT Protein phosphorylation plays important roles in short-term regulation of photosynthetic electron transfer. In a mechanism known as state transitions, the kinase STATE TRANSITION 7 (STT7) Chlamydomonas reinhardtii phosphorylates components light-harvesting antenna complex II (LHCII). This reversible governs dynamic allocation part LHCII to photosystem I or II, depending on light conditions and metabolic demands. Little is however green alga counteracting phosphatase(s). Arabidopsis,...
Abstract The virucidal efficacy of disinfectants is typically assessed by infectivity assay utilizing a single type host cell. Enteroviruses infect multiple cells via different entry routes, and each route may be impaired to varying extent given disinfectant. Yet, it not known how the choice for titration affects observed inactivation kinetics. Here, we evaluated kinetics echovirus 11 (E11) free chlorine, ultraviolet (UV) irradiation, heat, using three (BGMK, RD, A549). E11 chlorine occurred...