A5007195025- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Bone health and treatments
- Muscle and Compartmental Disorders
- Bone health and osteoporosis research
- Central Venous Catheters and Hemodialysis
- Magnesium in Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Trace Elements in Health
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Anesthesia and Pain Management
- Cardiovascular Conditions and Treatments
- Cardiac Arrhythmias and Treatments
- Renal function and acid-base balance
- Pharmacological Effects and Toxicity Studies
- Diagnosis and treatment of tuberculosis
- Bipolar Disorder and Treatment
- Hepatitis B Virus Studies
- Bone and Joint Diseases
- Pelvic floor disorders treatments
- Atrial Fibrillation Management and Outcomes
- Nutrition and Health in Aging
- Gut microbiota and health
Universidade do Porto
2016-2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2024
Universidade de São Paulo
1996-2024
Hospital de São João
2001-2023
Institute of Mechanical Engineering and Industrial Mangement
2020
Bayer (Germany)
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Universidade Federal de Lavras
2017
Sir Charles Gairdner Hospital
2013
Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and well-established risk factor for the development of cardiovascular (CVD). Gut dysbiosis may contribute to CVD inflammation CKD patients. Nonetheless, role gut blood microbiomes CKD-associated VC remains unknown. Therefore, this pilot study aimed explore link between patients on peritoneal dialysis (CKD-PD). Our results showed relative changes specific taxa CKD-PD with without VC, namely Coprobacter,...
Secondary hyperparathyroidism (SHPT) is associated with increased bone turnover, risk of fractures, vascular calcifications, and cardiovascular all-cause mortality. The classical treatment for SHPT includes active vitamin D compounds phosphate binders. However, achieving the optimal laboratory targets often difficult because sterols suppress parathyroid hormone (PTH) secretion, while also promoting calcium intestinal absorption. Calcimimetics increase sensitivity calcium-sensing receptor, so...
Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it an invasive procedure. Despite growing interest in ability newer biomarkers to discriminate between different forms ROD, data on pre-dialysis patients are scarce.
Este artigo analisa o impacto das ferramentas de inteligência artificial (IA) na personalização do ensino, com ênfase no contexto educacional brasileiro. A pesquisa parte da justificativa que a IA tem potencial transformar práticas pedagógicas, promovendo ambientes aprendizagem adaptativos e inclusivos. No entanto, sua aplicação enfrenta desafios como desigualdade acesso à tecnologia, falta infraestrutura adequada lacunas formação docente. O objetivo deste estudo é compreender pode ser...
Este artigo analisa a influência dos jogos e brincadeiras no desenvolvimento cognitivo emocional de crianças na primeira infância, ressaltando ludicidade como elemento essencial para formação integral. A pesquisa fundamenta-se premissa que atividades lúdicas promovem habilidades memória, atenção, criatividade empatia, sendo fundamentais tanto ambiente escolar quanto familiar. O objetivo do estudo é compreender os contribuem o infantil identificar desafios relacionados à valorização da...
Purpose: Bone biopsy is the only technique capable of comprehensively assessing all bone parameters, including turnover, microarchitecture, and mineralization, yet its clinical utility debated. This study evaluates role in routine diagnostic therapeutic applications. Methods: A retrospective analysis was conducted on 22 horizontal transiliac biopsies from 20 patients referred for rheumatology consultation between August 2016 May 2022. Diagnoses included osteoporosis, adynamic disease,...
O abdômen agudo é uma emergência médica caracterizada por dor abdominal intensa e súbita, geralmente de origem intra-abdominal não traumática. Essa condição representa das causas mais frequentes atendimentos em serviços requer diagnóstico intervenção precoces para evitar complicações graves. Esta revisão narrativa teve como objetivo reunir sintetizar informações científicas acerca do agudo, incluindo definição, epidemiologia, etiopatogenia, quadro clínico tratamento. Para isso, foram...
The spectrum of renal osteodystrophy (ROD) in peritoneal dialysis (PD) patients remains to be clarified. Ideal intact parathormone (iPTH) levels range is still not defined. role sclerostin, dickkopf-related protein 1, osteoprotegerin, and receptor activator for nuclear factor κB ligand the diagnosis ROD needs elucidated. In this cross-sectional study, tetracycline double-labeled bone biopsy was performed 49 with histomorphometric analysis according Kidney Disease Improving Global Outcomes...
Diabetes, dyslipidemia, older age, gender, urinary tract infections, and recent antibiotic intake have been associated with a decrease in the urobiome richness other fluctuations this microbiome. Gut blood microbiome reported to be altered patients chronic kidney disease (CKD), specifically peritoneal dialysis (PD) patients. Still, there are currently no studies describing urogenital CKD-PD In study we characterized profile 46 PD analyzed its clinical inflammatory parameters.
Introduction:Cuff-shaving has been described as a salvage technique for refractory exit-site infections, with conflicting data regarding infection and catheter outcomes. We describe our experience cuff-shaving rescue therapy infections unresponsive to systemic therapy.Methods:We retrospectively reviewed patients who underwent between January 2012 June 2017. Refractory was defined purulent discharge from the exit site no clinical response after 3 weeks of antibiotic...
Hepatitis B virus (HBV) reactivation in kidney transplant recipients (KTR) involves important morbidity and mortality. Despite being more common patients who are HBsAg-positive, it may occur with clinically resolved infection (HBsAg-negative anti-HBc-positive), whom the presence of protective anti-HB antibody is thought to decrease risk reactivation. Data regarding rates this population scarce. To retrospectively evaluate HBV KTR previously infection. Retrospective cohort study including...
Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity mortality this population. linked to disordered mineral metabolism has been associated with bone histomorphometry changes CKD. However, data on predialysis scarce.
Data regarding vascular calcification (VC) in contemporary peritoneal dialysis (PD) patients is scarce. Bone–vascular axis has been demonstrated hemodialysis (HD). However, studies showing the link between bone disease and VC PD are lacking. The role of sclerostin, dickkopf-related protein 1 (DKK-1), receptor activator for nuclear factor kB ligand osteoprotegerin (OPG) remains to clarify. Bone biopsy was performed 47 prevalent with histomorphometric analysis. Patients were submitted pelvis...
Selecting a polymer depends on its characteristics, the properties of drug and remaining ingredients in formulation. The drug, when incorporated into polymeric matrix, can show several advantages compared with conventional form. In this context, work describes preparation characterization polyethylene glycol (PEG 4000) derivative particles loaded benznidazole, as well evaluates their trypanocidal activity. work, reactions to modify PEG 4000 subsequent incorporation benznidazole were made....
Chronic Kidney Disease (CKD) is a growing public-health concern worldwide. Patients exhibit compromised immunity and are more prone to infection than other populations. Therefore, oral colonization by clinically relevant members of the Enterobacteriaceae family, major agents both nosocomial dialysis-associated infections with frequent prevalence antibiotic resistances, may constitute serious risk. Thus, this study aimed assess occurrence enterobacteria their resistance profiles in cavity CKD...
Bone disease after kidney transplant (KT) results from multiple factors, including previous bone and mineral metabolism disturbances effects of transplant-related medications. New biomolecules have been recently associated with the development progression chronic disease-associated disorder (CKD-MBD). These include sclerostin soluble receptor activator nuclear factor-kB ligand (sRANKL).To better understand role biomarkers in post-transplant disease, this study was designed to prospectively...