A5016473165- Sports Performance and Training
- Vitamin D Research Studies
- Cardiovascular and exercise physiology
- Thyroid Disorders and Treatments
- Parathyroid Disorders and Treatments
- Heart Failure Treatment and Management
- Bone health and osteoporosis research
- Physical Activity and Health
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Iron Metabolism and Disorders
- Exercise and Physiological Responses
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- Growth Hormone and Insulin-like Growth Factors
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- High Altitude and Hypoxia
Universidade do Porto
2015-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2024
Hospital de São João
2015-2024
Hospital Braga
2022
University of Minho
2022
University College London
2022
University of Coimbra
2021
Centro Hospitalar do Tâmega e Sousa
2021
Centre National de la Recherche Scientifique
2006
Chronic administration of moderate amounts red wine has been associated with a protective effect on the cardiovascular system. This study examined whether polyphenols prevent angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate underlying mechanism.Hypertensive rats were obtained by 14-day infusion Ang II. Red administered drinking water one week before during infusion. Arterial pressure was measured conscious rats. Ex vivo vascular...
Vitamin D deficiency has been associated with significant changes in dental structures. In children, it can induce enamel and dentin defects, which have identified as risk factors for caries. This study aimed to assess the association between low serum 25-hydroxyvitamin (25(OH) D) levels (<30 ng/mL) prevalence of caries permanent teeth mixed dentition 7-year-old children. A sample 335 children from population-based birth cohort Generation XXI (Porto, Portugal) was included. Data on...
Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it an invasive procedure. Despite growing interest in ability newer biomarkers to discriminate between different forms ROD, data on pre-dialysis patients are scarce.
Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism skeletal homeostasis. Estimates of the VitD status several European countries show large variations between them. In addition, no national population-based estimate has been published. PTH may also cardiovascular risk, which suggested to be associated with metabolic syndrome (MetS) is very prevalent Portugal. The goal our study was evaluate prevalence hypovitaminosis its determinants as well serum level...
Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life their offspring. In contrast, exercise is recognized as non-pharmacological strategy against dysfunctions to lifestyle disorders. Therefore, we investigated whether delays the development of alterations GDM mothers life, but also protects 6-week-old male offspring from adverse effects maternal diet.Female Sprague-Dawley rats were...
The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, national metabolic syndrome remains high. association pathology with cardiovascular risk addressed but is still unclear. Our study aimed to evaluate assess associations thyroid-stimulating hormone hormones antibodies syndrome, its components, other possible determinants a sample.The present included subsample 486 randomly selected participants from nationwide...
Background Thyroid hormones are important modulators of cardiovascular function. Both hypothyroidism and hyperthyroidism known to contribute an increased risk. It remains uncertain whether thyroid level within the euthyroid range associated with cardiometabolic We aimed evaluate association between function levels risk in a population-based cohort. Methods Eight hundred thirty-five subjects aged ≥45 years from EPIPorto cohort were included. excluded participants TSH, free T4 (FT4), or T3...
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, naive RA, we performed comprehensive clinical molecular profiling 267 RA patients 52 healthy vaccine recipients for up to 18 months establish high quality sample biobank including plasma, serum, cells, urine, genomic DNA, RNA from whole...
Abstract Background Several strategies have been developed to counteract liver injury as a consequence of nonsteroid anti‐inflammatory drugs toxicity. Here, we aimed determine whether physical exercise results in mitochondrial protection against vitro diclofenac Material and methods Male adult Sprague‐Dawley rats were divided into sedentary, 12‐week endurance training ( ET ) voluntary activity VPA ). In function assessed by oxygen consumption, transmembrane electric potential (ΔΨ)...
This pilot study aimed to assess the impact of substituting a traditional lunch for vegetarian legume-based meal on blood and anthropometric parameters in group omnivorous adults. A one-group comparison, quasi-experimental dietary intervention was designed. offered 8 consecutive weeks (weekdays) non-vegetarian individuals (n = 26), (28 years [P
Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure function. However, the association of thyroid function within normal range general population remains uncertain.Eight hundred thirty-five subjects aged ≥45 years from EPIPorto cohort (evaluation between 2006 2008) were cross-sectionally analyzed. We excluded participants TSH, free T4 (FT4), or T3 (FT3) outside reference self-reported cardiovascular disease. Cardiac evaluated by echocardiography. used...
Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators leukemic cells vital to gain clinical insights into biology AML. Iron key extrinsic regulator cancer, but its systemic regulation remains poorly explored in To address this question, we studied iron metabolism patients AML at diagnosis mechanisms involved using syngeneic MLL-AF9-induced mouse model. We found that disorder unique...
Specialized pro-resolving mediators (SPMs) have recently emerged as promising therapeutic approaches for neuropathic pain (NP). We evaluated the effects of oral treatment with SPM Maresin 1 (MaR1) on behavioral responses and spinal neuroinflammation in male female C57BL/6J mice spared nerve injury (SNI)-induced NP. MaR1, or vehicle, was administered once daily, post-surgical days 3 to 5, by voluntary intake. Sensory-discriminative affective-motivational components were von Frey place...
To predict protective immunity to SARS-CoV-2, cellular seems be more sensitive than humoral immunity. Through an Interferon-Gamma (IFN-γ) Release Assay (IGRA), we show that, despite a marked decrease in total antibodies, 94.3% of 123 healthcare workers have positive response 6 months after inoculation with the 2nd dose BNT162b2 vaccine. Despite qualitative relationship found, did not observe quantitative correlation between IFN-γ and IgG levels against SARS-CoV-2. Using stimulated whole...
Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) comorbidities such as hypertension obesity was also assessed.Blood spot urine were collected "severe" (n = 26), "critically ill" 17) ill VV-ECMO"...
(1) Background: half-marathon races are popular among recreational runners, with increases in participation middle-aged and women. We aimed to determine the effects of two training programs on hematological biochemical markers female runners; (2) Methods: ten women (40 ± 7 years) followed moderate intensity continuous (MICT), based running volume below 80% V˙O2max, another high interval (HIIT) at 80%-100% less volume, combined eccentric loading exercise. Hematology, plasma osmolality,...
Aims: Inflammation-driven endothelitis seems to be a hallmark of acute heart failure (AHF) and cardiogenic shock (CS). Endocan, soluble proteoglycan secreted by the activated endothelium, contributes inflammation endothelial dysfunction, but has been scarcely explored in human AHF. We aimed evaluate serum (S-Endocan) urinary endocan (U-Endocan) profiles AHF CS patients correlate them with biomarkers/parameters inflammation, activation, cardiovascular dysfunction prognosis. Methods: Blood...
We studied the long-term effects of a multicomponent exercise training protocol (recreational team handball training, RTH) on global health status in inactive postmenopausal women. Participants (n = 45; age 65 ± 6 years, stature 157 cm, body mass 66.2 9.4 kg, fat 41.4 5.5%, VO2peak 25.7 3.6 mL/min/kg) were randomised into control group (CG; n 14) and (EXG; 31, performing two to three weekly 60-min RTH sessions). Attendance was 2.0 0.4 sessions/week (first 16 weeks) 1.4 0.5 (following 20 mean...
We determined the coadjuvant effect of a recreational futsal (RF) programme versus standard care alone (CON) in men with treated arterial hypertension (TAHT). Thirty-nine TAHT were randomised to RF (N = 20; 48 ± 8 years; systolic blood pressure [SBP]: 122 14 mmHg) 2–3 one-hour sessions/week for 3 months, or CON 19; 51 6 SBP: 126 13 mmHg). Participants assessed at baseline, and after 1 month training cessation (4 months). Mean attendance was 60 23%. At 3-months, there no between-group...
Bone disease after kidney transplant (KT) results from multiple factors, including previous bone and mineral metabolism disturbances effects of transplant-related medications. New biomolecules have been recently associated with the development progression chronic disease-associated disorder (CKD-MBD). These include sclerostin soluble receptor activator nuclear factor-kB ligand (sRANKL).To better understand role biomarkers in post-transplant disease, this study was designed to prospectively...