A5068217084- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic function and diabetes
- Birth, Development, and Health
- Veterinary Oncology Research
- Gestational Diabetes Research and Management
- Virus-based gene therapy research
- Lung Cancer Research Studies
- Research on Leishmaniasis Studies
- Agricultural safety and regulations
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Trypanosoma species research and implications
- Salivary Gland Tumors Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Environmental Toxicology and Ecotoxicology
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Carcinogens and Genotoxicity Assessment
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2024
Escola Universitária Vasco da Gama
2024
Universidade do Porto
2017-2023
IPO Porto
2019-2022
University of Trás-os-Montes and Alto Douro
2017
Centro Hospitalar de Lisboa Ocidental
2017
Every year, up to 90.000 new cases of Visceral Leishmaniasis and 30.000 deaths are estimated occur worldwide. Such numbers give relevance the continuous study this complex form disease: both a zoonosis an anthroponosis; two known etiological agents (Leishmania infantum L. donovani, respectively); with average ratio 1 symptomatic per 10 asymptomatic individuals; sometimes associated atypical clinical presentations. This complexity, which results from long co-evolutionary process involving...
Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life their offspring. In contrast, exercise is recognized as non-pharmacological strategy against dysfunctions to lifestyle disorders. Therefore, we investigated whether delays the development of alterations GDM mothers life, but also protects 6-week-old male offspring from adverse effects maternal diet.Female Sprague-Dawley rats were...
ATRX is a chromatin remodeller that maintains telomere homeostasis. Loss of described in approximately 10% pancreatic neuroendocrine tumours (PanNETs) and associated with poorer prognostic features. Here, we present genetically engineered mouse model (GEMM) addressing the role Atrx loss (AtrxKO) β cells, evaluating large cohort ageing mice (for up to 24 months (mo.)). did not cause PanNET formation but rather resulted worsening ageing-related inflammation endocrine dysfunction first year...
Atrx loss was recently ascertained as insufficient to drive pancreatic neuroendocrine tumour (PanNET) formation in mice islets. We have identified a preponderant role of the endocrine dysfunction Rip-Cre;AtrxKO genetically engineered mouse model (GEMM). To validate impact different Cre-driver line, we used similar methodologies and characterised Pdx1-Cre;AtrxKO (P.AtrxKO) GEMM search for PanNET fitness disruption period up 24 months. Male female presented phenotypes. Compared P.AtrxWT,...
Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, thyroid gland was revealed one of relevant targets virus. Regardless viral expression these molecules their putative role neoplastic transformation thyrocytes has not been thoroughly explored. In this work, we aimed characterize mRNA protein pattern ACE2, TMPRSS2, a series patients with lesions. Our main results significantly decreased ACE2...
In 2016, with the publication of novel guidelines for classification central nervous system (CNS) tumours by World Health Organization (WHO) (1), there was a paradigm shift in classical diagnosis, mainly based microscopy, integration molecular markers stratification.