A5027023125- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Ion Transport and Channel Regulation
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- Renal and related cancers
- Cellular Mechanics and Interactions
- Cystic Fibrosis Research Advances
- Birth, Development, and Health
- Genetic and Kidney Cyst Diseases
- Adipose Tissue and Metabolism
- Connexins and lens biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cholesterol and Lipid Metabolism
- BRCA gene mutations in cancer
- Innovative Microfluidic and Catalytic Techniques Innovation
- Estrogen and related hormone effects
- RNA regulation and disease
- Renal Diseases and Glomerulopathies
- Cancer-related Molecular Pathways
- Ovarian function and disorders
- Telomeres, Telomerase, and Senescence
- Hippo pathway signaling and YAP/TAZ
- Thyroid Cancer Diagnosis and Treatment
- Biosensors and Analytical Detection
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2022-2024
Universidade do Porto
2014-2023
IPO Porto
2022-2023
University of Beira Interior
2013-2017
Population Council
2017
The blood-testis barrier (BTB), conferred by Sertoli cells in the mammalian testis, is an important ultrastructure that supports spermatogenesis. Studies using animal models have shown a disruption of BTB leads to meiotic arrest, causing defects spermatogenesis and male infertility. To better understand regulation dynamics, we report findings herein role ribosomal protein S6 (rpS6), downstream signaling target rapamycin complex 1 (mTORC1), promoting testis vivo, making “leaky.”...
In the rat testis, studies have shown that cell polarity, in particular spermatid to support spermatogenesis is conferred by coordinated efforts of Par-, Crumbs-, and Scribble-based polarity complexes seminiferous epithelium. Furthermore, planar (PCP) PCP proteins such as Van Gogh-like 2 (Vangl2) testis. On other hand, junctions at Sertoli cell-spermatid (steps 8-19) interface are exclusively supported adhesion protein (for example, α6β1-integrin-laminin-α3,β3,γ3 nectin-3-afadin) actin-rich...
Abstract Men with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are usually subfertile/infertile. Besides playing a role Cl − /HCO 3 transport, it has been proposed that CFTR interacts water membrane transport systems, particularly aquaporins, to control seminiferous tubular secretion, which is regulated by somatic Sertoli cells (SCs). As aquaporin‐9 (AQP9) highly expressed throughout male reproductive tract, we hypothesized also present rat SCs and...
Insulin is essential for the regulation of glucose homeostasis. dysfunction occurs in several pathologies, such as diabetes mellitus, which associated with fertility problems. Somatic Sertoli cells (SCs) not only metabolize to lactate, central energy source used by developing germ cells, but also determine cell population size. If a deregulation SCs apoptosis occurs, it will affect compromising spermatogenesis. As apoptotic signaling hormonally regulated process, we hypothesized that lack...
ABSTRACT Alterations in the expression or function of cell adhesion molecules have been implicated all steps tumor progression. Among those, P-cadherin is highly enriched basal-like breast carcinomas, playing a central role cancer self-renewal, collective migration and invasion. To establish clinically relevant platform for functional exploration effectors vivo, we generated humanized Drosophila model. We report that actin nucleators, Mrtf Srf, are main fly. validated these findings human...
Telomerase promoter (TERTp) mutations are frequently observed in various types of tumours and commonly characterised by two specific hotspots located at positions -124 -146 upstream the start codon. They enhance
The screening of TERT promoter (
Atrx loss was recently ascertained as insufficient to drive pancreatic neuroendocrine tumour (PanNET) formation in mice islets. We have identified a preponderant role of the endocrine dysfunction Rip-Cre;AtrxKO genetically engineered mouse model (GEMM). To validate impact different Cre-driver line, we used similar methodologies and characterised Pdx1-Cre;AtrxKO (P.AtrxKO) GEMM search for PanNET fitness disruption period up 24 months. Male female presented phenotypes. Compared P.AtrxWT,...
Abstract Alterations in the expression or function of cell adhesion molecules have been implicated all steps tumour progression. Among those, P-cadherin is highly enriched basal-like breast cancer, a molecular subset triple-negative carcinomas, playing central role inducing cancer self-renewal, as well collective migration and invasion capacity. To decipher P-cadherin-dependent signalling network, we generated humanised fly model, establishing clinically relevant platform for functional...