A5018887674- Silymarin and Mushroom Poisoning
- Drug-Induced Hepatotoxicity and Protection
- Fungal Biology and Applications
- Iron Metabolism and Disorders
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Reproductive System and Pregnancy
- Cholinesterase and Neurodegenerative Diseases
- Economic Growth and Development
- Adenosine and Purinergic Signaling
- Venomous Animal Envenomation and Studies
- Synthesis and bioactivity of alkaloids
- Molecular Biology Techniques and Applications
- Reproductive Physiology in Livestock
- Firm Innovation and Growth
- RNA and protein synthesis mechanisms
- Bee Products Chemical Analysis
- Eicosanoids and Hypertension Pharmacology
- Entrepreneurship Studies and Influences
- Calcium signaling and nucleotide metabolism
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Toxin Mechanisms and Immunotoxins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Universidade do Porto
2016-2023
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021-2023
Rede de Química e Tecnologia
2017-2022
Previous in vivo work showed that resveratrol has beneficial effects Alzheimer's disease (AD) pathology, resulting increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding its aggregation and toxicity, is reduced the cerebrospinal fluid (CSF) plasma AD. Further, TTR, stabilizing native tetrameric structure. To further explore mechanism neuroprotection conferred by AD, was administered diet to 5- 8-month-old AD transgenic female mice carrying just 1 copy...
Understanding in vivo biodistribution of iron oxide nanoparticles (IONs), and the involvement phagocyte system this process, is crucial for assessment their potential health risk. In present study, histochemical expression liver spleen sections CD-1 mice (aged 8 weeks) was quantified, 24 h after intravenous administration polyacrylic acid-coated IONs (PAA-coated IONs) (8, 20, 50 mg/kg). Organ were stained with Perls' Prussian blue detection, followed by quantification deposition ImageJ...
During infections, the host redistributes iron in order to starve pathogens from this nutrient. Several proteins are involved absorption, transport, and storage. Ferritin is most important storage protein. It composed of variable proportions two peptides, L- H-ferritins (FTL FTH). We previously showed that macrophages increase their expression FTH1 when they infected vitro with Mycobacterium avium, without a significant FTL. In work, we investigated role macrophage M. avium infection vivo....
Although considerable research has been devoted to the study of effect entrepreneurship on economic growth, fewer studies have analyzed types (opportunity vs necessity) growth. Moreover, latter set overlooked relevance human capital as a mediating factor in relation between (types of) and The aim present is fill this gap by assessing extent which direct indirect (the entrepreneurship, via capital, matters for countries’ In methodological terms, we resort fixed effects panel data estimations,...
ATRX is a chromatin remodeller that maintains telomere homeostasis. Loss of described in approximately 10% pancreatic neuroendocrine tumours (PanNETs) and associated with poorer prognostic features. Here, we present genetically engineered mouse model (GEMM) addressing the role Atrx loss (AtrxKO) β cells, evaluating large cohort ageing mice (for up to 24 months (mo.)). did not cause PanNET formation but rather resulted worsening ageing-related inflammation endocrine dysfunction first year...
The purpose of an experimental design is to improve the productivity experimentation. It efficient procedure for planning experiments, so data obtained can be analyzed yield a valid and objective conclusion. This approach has been used as important tool in optimization different analytical approaches. A D-optimal was here, first time, optimize conditions detection reactive oxygen species (ROS) produced by human blood from healthy donors, biological matrix that better resembles physiologic...
Atrx loss was recently ascertained as insufficient to drive pancreatic neuroendocrine tumour (PanNET) formation in mice islets. We have identified a preponderant role of the endocrine dysfunction Rip-Cre;AtrxKO genetically engineered mouse model (GEMM). To validate impact different Cre-driver line, we used similar methodologies and characterised Pdx1-Cre;AtrxKO (P.AtrxKO) GEMM search for PanNET fitness disruption period up 24 months. Male female presented phenotypes. Compared P.AtrxWT,...