A5075973941- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Salivary Gland Tumors Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Ear and Head Tumors
- Medical Imaging and Pathology Studies
- Oral and Maxillofacial Pathology
- Bird parasitology and diseases
- Cell Adhesion Molecules Research
- Tumors and Oncological Cases
- Traumatic Ocular and Foreign Body Injuries
- Cutaneous Melanoma Detection and Management
- Hair Growth and Disorders
- Hemoglobinopathies and Related Disorders
- Cancer Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Ultrasound and Hyperthermia Applications
- Wnt/β-catenin signaling in development and cancer
Universidade do Porto
2013-2024
Escola Universitária Vasco da Gama
2024
Instituto Português de Oncologia Francisco Gentil
2018
IPO Porto
2018
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018
Instituto de Biologia Molecular e Celular
2018
Fernando Pessoa University
2018
Institute of Biomedical Science
2017
Histopathology remains the cornerstone for diagnosing canine mammary tumors (CMTs). Recently, 2 classification systems (the World Health Organization [WHO] of 1999 and proposal 2011) grading methods based on human Nottingham grade have been used by pathologists. Despite some evidence that histological subtype are prognostic factors, there is no comprehensive comparative study these in same series CMTs. In this study, classifications were simultaneously applied to a cohort 134 female dogs...
The animal cancer burden is essential for the translational value of companion animals in comparative oncology. present work aims to describe, analyze, and compare frequencies associations tumors dogs cats based on Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 2020, 81% (n = 7355) belonged dogs. In comparison, have a general one-year right advance mean age diagnosis compared multivariate topography group analysis shows distinct pattern between two...
Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients make more accurate decisions. Based on a sample 16,272 cancer records, including 3266 cats 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed compare profile between considering animal-related factors (sex, age, breed), topography, geographic location using mixed-effects logistic regression model. Cats had higher proportion malignant...
ABSTRACT Inflammation is a frequent finding in feline mammary neoplasms. Recent research suggests that the presence and location of tumour‐associated immune cells might play significant role clinical outcome carcinomas. The present study aimed to characterise overall inflammatory infiltrates healthy, hyperplastic/dysplastic, benign malignant lesions gland, evaluate its association with clinicopathological features. Perilesional intralesional foci were evaluated 307 from 185 queens,...
Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, lines evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning biosynthesis, metabolism mechanism action was recognized associated human breast cancer susceptibility, clinical features progression. Although some variations in canine ESR1 gene were reported, their influence clinicopathological progression tumors has not...
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high doxorubicin or surgery alone in cats mammary carcinoma. Medical records 228 female treated for carcinoma between 2008 2018, were reviewed eight veterinary institutions. Only complete tumour staging radical mastectomy included study. One hundred thirty-seven divided into three treatment groups: group 1 (n = 80) surgery, 2 34) that had...
Abstract Background Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male female dogs, respectively. The aims of this study were to report occurrence canine cutaneous a pathology laboratory located Northern Portugal between 2014 2020, characterize categorize anatomical locations, breed, age, sex animals affected with different types neoplasms. Results Throughout 7-year study, 1,185 cases diagnosed as tumors, 62.9% being classified benign, 37.1%...
Abstract Sustainable farming of fish species depends on emerging new feed ingredients, which can alter the features digestive tract and influence animals’ overall health. Recent research has shown that functional feeds hold great potential for enhancing robustness by evoking appropriate responses at intestine level. However, there is a lack extensive accurate descriptions morphology gastrointestinal most farmed fish. We have characterised European seabass thoroughly, targeting four segments...
Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little known regarding their influence on canine mammary tumor risk. We assessed SNPs genes related to human susceptibility, respect tumors dogs. Sixty-seven proto-oncogenes, suppressor genes, involved DNA repair, hormonal metabolism were evaluated 212 bitches 161 free neoplasia. A significant...
Background Cell blocks and immunohistochemistry (IHC) are increasingly recognized as being complementary tools for cytologic diagnostics, especially neoplastic diseases. Objectives The study aimed to evaluate the utility of cell tube block (CTB) IHC refining diagnosis effusions in dogs cats. Methods Cavitary (n = 25) from cats classified by cytology reactive, neoplastic, borderline (suspicious neoplasia), chylous were studied. CTB sections stained with H&E, immunostained PAX‐5, CD3,...
Necrosis is a common finding in human and animal neoplasms. The percentage of tumor necrosis included grading schemes veterinary oncology; however, evaluation methods are often overlooked. Different studies have assessed the prognostic value feline mammary tumors with contradictory results, which could be related to methodologic variability. In this study, comprehensive (FMTs) was conducted, by applying semi-quantitative quantitative methodology for assessing necrosis. interobserver...
Abstract E‐cadherin is a cell adhesion molecule that participates in several cellular processes guarantee the maintenance of structural and functional integrity epithelial tissues. plays an important role mammary carcinogenesis, various studies have demonstrated effect CDH1 genetic variation risk, progression biological behaviour human breast cancer. Although there are some recognized variations canine gene, their influence tumour development has not been previously evaluated. In this study,...
The enzyme catechol-o-methyltransferase (COMT) is responsible for inactivation of catechol estrogens, which are well-recognized carcinogenic metabolites. Two single-nucleotide polymorphisms (SNPs) in canine COMT gene were previously associated with the age onset mammary tumours and clinical progression disease. However, no information available regarding impact other known SNPs tumours. aim present study to evaluate influence SNP clinicopathological features outcome A case series was...
Fine-needle aspirate (FNA) cytology is often the first-choice method for diagnosing gastrointestinal nodular lesions. The FNA material can be converted to histopathology specimens by a needle rinse cell block (NRCB) technique, allowing ancillary studies refine cytologic diagnosis. Despite use in human pathology, NRCB has never been applied canine or feline neoplasia.This study described methodology and its diagnostic utility specific cases of neoplastic lesions.Needle rinses with saline were...
Dysregulation of cellular iron homeostasis in human breast cancer is reflected by the altered expression regulatory proteins. The expressions iron-related proteins mammary glands cats and dogs have not been assessed. We evaluated ferritin, ferroportin, hepcidin transferrin receptor 1 benign malignant gland lesions dogs. Iron deposition was detected using Perls' Prussian blue staining. found no major differences between either or dogs; however, these species exhibited accumulation lesions....
Abstract Acute phase proteins (APP) and biomarkers of oxidative status change in human canine mammary tumours, however, they have not been studied feline tumours. The aims this study were to investigate the APP antioxidant responses malignant evaluate their relation with tumour features, assess prognostic value. Serum amyloid A (SAA), haptoglobin (Hp), albumin, butyrylcholinesterase (BChE), insulin‐like growth factor1 (IGF1), paraoxonase1 (PON1), total serum thiols (Thiol), glutathione...
ABSTRACT Mast cell tumours (MCTs) are the most frequent cutaneous neoplasia of dog, and they have very variable biological behaviour survival times. Surgery is still best treatment, despite several adjuvant therapies described, many cases aggressive resistant to these treatments making it urgent find new therapeutic targets. Nowadays, immunotherapy targeting immune checkpoints has been described as a complementary treatment for human cancers, but scarcely studied in veterinary medicine....
The role of HER2 in canine mammary tumors is not completely elucidated, and the contradictory results published so far may be, part, explained by genetic variability recognized gene. Single nucleotide polymorphism (SNPs) were recently associated with less aggressive tumor histotypes. This study assesses relationship between SNPs rs24537329 rs24537331 gene clinicopathological characteristics outcome a group 206 female dogs. Allelic variants observed 69.8% 52.7% dogs for SNP rs24537331,...