A5090764307- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Sexual function and dysfunction studies
- Genital Health and Disease
- Urologic and reproductive health conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Cystic Fibrosis Research Advances
- Reproductive System and Pregnancy
- COVID-19 and Mental Health
- Extracellular vesicles in disease
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- FOXO transcription factor regulation
- Toxoplasma gondii Research Studies
- Testicular diseases and treatments
- Appendicitis Diagnosis and Management
- Case Reports on Hematomas
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021-2025
AC Camargo Hospital
2025
Universidade de São Paulo
2021-2024
Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal
2016
COVID-19 represents a public health emergency, whose mechanism of which is not fully understood. It speculated that microRNAs may play crucial role in host cells after infection by SARS-CoV-2. Thus, our study aimed to analyze the expression miR-200c-3p saliva samples from patients with COVID-19. One handred eleven were divided into 4 groups. Group I: 39 negative for Covid-19; II: 37 positive and symptomatic patients, no indication hospitalization; III: 21 respiratory disorders...
The infection by COVID-19 is a serious global public health problem. An efficient way to improve this disease's clinical management would be characterize patients at higher risk of progressing critically severe using prognostic biomarkers. telomere length could used for purpose. Telomeres are responsible controlling the number maximum cell divisions. biomarker aging and several diseases. We aimed compare leukocyte (LTL) between without with different severity infection. Were included 53 who...
Prostate cancer (PCa) has a high prevalence and represents an important health problem, with increased risk of metastasis. With the advance CRISPR-Cas9 genome editing, new possibilities have been created for investigating PCa. The technique is effective in knockout oncogenes, reducing tumor resistance. MMP9 miR-21 target genes are associated PCa progression; therefore, we evaluated MMP-9 targets using system. Single guide RNAs (sgRNAs) sequences were inserted into PX-330 plasmid, transfected...
specialists have an urge for biomarkers that can discriminate indolent prostate cancer from aggressive tumors. Ki67 is a proliferation marker, and its expression associated with the aggressiveness of several cancers.analyze in samples correlating disease.Ki67 mRNA levels were determined utilizing data TCGA cohort (Tumor(n)=492 control(n)=52). The protein was on 94 biopsies patients by immunohistochemical assay.in mRNA, upregulation tissue (p<0.0001) worst disease-free survival (p=0.035)....
BACKGROUND/AIMS: Cholesterol modulates intratumoral androgenic signaling in prostate cancer; however, the molecular mechanisms underlying these changes castration-resistant cancer (CRPC) are not fully elucidated. Herein, we investigated effect of cholesterol on androgen receptor (AR) coactivators expression and tumorigenesis vitro vivo. METHODS: monitored AR (SRC-1, 2, 3 PCAF) genes PC-3 cells exposed to 2µg/mL for 8 hours by qPCR. We also performed cell migration at 0, 8, 24, 48 72h flow...
MicroRNAs (miRNAs) have gained a prominent role as biomarkers in prostate cancer (PCa). Our study aimed to evaluate the potential suppressive effect of miR-137 model advanced PCa with and without diet-induced hypercholesterolemia. In vitro, PC-3 cells were treated 50 pmol mimic for 24 h, gene protein expression levels SRC-1, SRC-2, SRC-3, AR evaluated by qPCR immunofluorescence. We also assessed migration rate, invasion, colony-forming ability, flow cytometry assays (apoptosis cell cycle)...
Peyronie's disease (PD) is characterized by the formation of fibrous plaque in tunica albuginea, causing several problems patients. The etiology this not fully understood, and there are few effective treatments. To better understand molecular pathways PD, we studied miR-29b, a microRNA that could be involved with illness. MicroRNAs endogenous molecules act inhibiting messenger RNA. MiR-29b regulates 11 20 collagen genes TGF-β1 gene, which related to PD progression.We compared miR-29b...
Abstract Background Telomere dysfunction is one of the hallmarks cancer and crucial to prostate carcinogenesis. TERF1 a gene essential telomere maintenance, its has already been associates with several cancers. target miR-155, this microRNA can inhibit expression promotes carcinogenesis in breast cancer. We aim analyze TERF1, mRNA level, involvement progression. Results Alterations DNA were evaluated using datasets primary tumor castration-resistant tumors (CRPC) deposited cBioportal. The...
Abstract Purpose To assess the role of p160 family, AR, and AR-V7 in different initial presentations prostate cancer their association with clinical endpoints related to tumor progression. Methods The study sample comprises 155 patients who underwent radical prostatectomy 11 healthy peripheral zone biopsies as control group. Gene expression was quantified by qPCR from tissue specimens. statistical analysis investigated correlations between gene levels, associations disease presence,...
Abstract Background Peyronie's disease is characterized by the formation of fibrotic plaques in penile tunica albuginea. Effective treatments are limited, warranting investigation new promising therapies, such as application microRNAs that regulate fibrosis‐related genes. Objective We aimed to investigate therapeutic potential mimicking microRNA‐29b a fibrin‐induced rat model disease. Material/methods The study was designed two phases. To establish an optimal model, rats received either...
RESUMO Introdução: especialistas precisam biomarcadores que podem discriminar o câncer de próstata indolente tumores agressivos. Ki67 é um marcador proliferação, e sua expressão está associada à agressividade vários tumores. Objetivo: analisar a do em amostras correlacionando com da doença. Métodos: os níveis mRNA foram determinados utilizando dados uma coorte TCGA (Tumor(n)=492 controle(n)=52). A proteína foi determinada 94 biópsias pacientes por ensaio imuno-histoquímica. Resultados: no...
You have accessJournal of UrologyCME1 Apr 2023MP36-14 MICRORNA-29B ATTENUATES FIBROSIS IN A RAT MODEL OF PEYRONIE’S DISEASE Patrícia Candido, Caroline Chiovatto, Ruan Pimenta, Poliana Romão, Vitória Ghazarian, Juliana Camargo, Vanessa Guimarães, Gabriel Santos, Iran Silva, Bruno Nascimento, Jorge Hallak, Miguel Srougi, William Nahas, Nayara Viana, Katia Leite, Sabrina Reis, and Feres Camargo Maluf CandidoPatrícia Candido More articles by this author , ChiovattoCaroline Chiovatto PimentaRuan...
Background/aim: The clinical spectrum of COVID-19 infection ranges from asymptomatic to deadly and potentially lethal disease. Although some studies have been performed, data on the long-term effects persistent symptoms after are limited. We aimed evaluate in an adult population with SARS-CoV-2 treated a patient clinic. Materials Methods: study included random sample 231 adults (≥18 years) positive outpatient test result for who were not hospitalized. adapted six quality life questionnaires...