A5057026560- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Oral and Maxillofacial Pathology
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- Esophageal Cancer Research and Treatment
- Microplastics and Plastic Pollution
- Gastric Cancer Management and Outcomes
- Recycling and Waste Management Techniques
- dental development and anomalies
- Microbial infections and disease research
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Veterinary Medicine and Surgery
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Caveolin-1 and cellular processes
- Genomic variations and chromosomal abnormalities
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
Universidade do Porto
2014-2024
University of Trás-os-Montes and Alto Douro
2019
IPO Porto
1995-2018
Instituto Português de Oncologia Francisco Gentil
2018
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018
Instituto de Biologia Molecular e Celular
2018
Fernando Pessoa University
2018
Institute of Biomedical Science
2009
Histopathology remains the cornerstone for diagnosing canine mammary tumors (CMTs). Recently, 2 classification systems (the World Health Organization [WHO] of 1999 and proposal 2011) grading methods based on human Nottingham grade have been used by pathologists. Despite some evidence that histological subtype are prognostic factors, there is no comprehensive comparative study these in same series CMTs. In this study, classifications were simultaneously applied to a cohort 134 female dogs...
Abstract Urea, the main nitrogenous waste product of protein metabolism, is eliminated almost exclusively by kidney, and hence, displays considerable clinical significance in assessment kidney disorders. The aim this study to prepare investigate potential swellable cross‐linked gelatin methacryloyl (c‐GelMA) microneedles (MNs) as a platform for minimally invasive extraction interstitial skin fluid (ISF) toward straightforward point‐of‐care healthcare monitoring renal complaints,...
Companion animals living in urban areas are exposed to environmental contaminants, which may include microplastics. A preliminary study was conducted by collecting postmortem samples from the internal tissue (lungs, ileum, liver, kidney, and blood clots) of 25 dogs (Canis familiaris) 24 cats (Felis catus) an environment Porto metropolitan area, Portugal. Suspected microplastics were found 80 35 (18 17 dogs), often occurring more than one same animal (71.4%), primarily under small sizes...
The animal cancer burden is essential for the translational value of companion animals in comparative oncology. present work aims to describe, analyze, and compare frequencies associations tumors dogs cats based on Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 2020, 81% (n = 7355) belonged dogs. In comparison, have a general one-year right advance mean age diagnosis compared multivariate topography group analysis shows distinct pattern between two...
The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely sodium carboxymethylcellulose (CMC), a water-soluble cellulose derivative with good film-forming ability, by micromolding technology for the transdermal delivery diclofenac salt (DCF). MNs ≈456 µm in height displayed adequate morphology, thermal stability up 200 °C, and required mechanical strength skin insertion (>0.15 N needle-1 ). Experiments ex vivo abdominal human demonstrate capability...
Abstract Although bioactive glasses are successfully used as bone substitutes, recent studies have revealed that the high alkali content in these leads to fast vivo degradation rates may not match rate of new ingrowth. This prompted us design and develop novel devoid but still demonstrate bioactivity vitro . article describes performance an alkali‐free glass with following composition (Wt %): 13.03 MgO–33.98 CaO–13.37 P 2 O 5 −38.84 SiO −0.77 CaF (labelled FastOs ® BG). An animal model was...
Freshwater benthic environments are among the major sinks of microplastics (MPs, < 5 mm) sourced on inland anthropogenic activities. The ecotoxicological effects MPs macroinvertebrates have been assessed preferably in collectors, shredders, and filter-feeders, but resulting insufficient knowledge potential trophic transfer its with predator behaviour such as planarians. This work evaluated behavioural (feeding, locomotion), physiological (regeneration) biochemical responses (aerobic...
ABSTRACT Inflammation is a frequent finding in feline mammary neoplasms. Recent research suggests that the presence and location of tumour‐associated immune cells might play significant role clinical outcome carcinomas. The present study aimed to characterise overall inflammatory infiltrates healthy, hyperplastic/dysplastic, benign malignant lesions gland, evaluate its association with clinicopathological features. Perilesional intralesional foci were evaluated 307 from 185 queens,...
Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, lines evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning biosynthesis, metabolism mechanism action was recognized associated human breast cancer susceptibility, clinical features progression. Although some variations in canine ESR1 gene were reported, their influence clinicopathological progression tumors has not...
Abstract Background Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male female dogs, respectively. The aims of this study were to report occurrence canine cutaneous a pathology laboratory located Northern Portugal between 2014 2020, characterize categorize anatomical locations, breed, age, sex animals affected with different types neoplasms. Results Throughout 7-year study, 1,185 cases diagnosed as tumors, 62.9% being classified benign, 37.1%...
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high doxorubicin or surgery alone in cats mammary carcinoma. Medical records 228 female treated for carcinoma between 2008 2018, were reviewed eight veterinary institutions. Only complete tumour staging radical mastectomy included study. One hundred thirty-seven divided into three treatment groups: group 1 (n = 80) surgery, 2 34) that had...
Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT1 /AT2 receptors. In this article, we aimed to explore which mediators and cells were involved in Ang II-mediated colonic contraction TNBS-induced rat model colitis. The contractile responses evaluated distinct regions control animals or colitis absence presence different antagonists/inhibitors....
Over the last decades, canines have experienced a marked increase in their lifespan, mirroring human populations. Several authors pointed out domestic dog as suitable animal model for geropathology translational research. The aim of this study is to assess age-related morbidities and mortality population 269 elderly (130 males 139 females) submitted necropsy. organic systems exhibiting higher number were reproductive, cardiovascular urinary and, females, also mammary gland. prevalence...
Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little known regarding their influence on canine mammary tumor risk. We assessed SNPs genes related to human susceptibility, respect tumors dogs. Sixty-seven proto-oncogenes, suppressor genes, involved DNA repair, hormonal metabolism were evaluated 212 bitches 161 free neoplasia. A significant...
Abstract Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and food industry. Consequently, increased use of AgNP industry has led to an unavoidable rise human exposure these nanoparticles. Their widespread raises concerns about potential hazards health, specifically their intestinal pro-inflammatory effects. Thus, main objective this study was evaluate biological effects two subacute doses 5 nm polyvinylpyrrolidone...
Eight cases of feline plasma cell pododermatitis, collected over a 3-year period, were studied using histological (haematoxylin and eosin), histochemical (methyl green-pyronin) immunohistochemical (antibody against lambda light chains immunoglobulins) techniques. No sex, breed or age predisposition, paw predilection was observed. The disease began as swelling the footpads, followed by ulceration. Histologically, lesions characterized presence large number cells in predominantly perivascular...