A5034189673- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- CAR-T cell therapy research
- Iron Metabolism and Disorders
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Oral health in cancer treatment
- Childhood Cancer Survivors' Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Family and Patient Care in Intensive Care Units
- Parvovirus B19 Infection Studies
- Protein Degradation and Inhibitors
- Neonatal Respiratory Health Research
IPO Porto
2012-2024
Instituto Português de Oncologia Francisco Gentil
2014-2023
Instituto Português de Oncologia de Coimbra Francisco Gentil
2014
Burnout is a professional syndrome associated with stress caused by overwork. Our aim was to calculate the prevalence of burnout and on medical residents Oncology, Haematology Radiotherapy in Portugal, as well determine predictors stress. An anonymous questionnaire applied (n = 118). Statistical analysis consisted descriptive inferential analysis. The calculated be 45.2 50%, respectively. dimensions that generated higher levels were 'dealing patients' 'overwork'. directly related dimension...
Real world effectiveness, toxicity and costs analyses from chimeric antigen receptor (CAR)-T cell therapy are of utmost relevance to determine whether how offer patients highly personalized immunotherapy. In this study, we aimed at describing CAR T-cells safety in a Portuguese Comprehensive Cancer Center. We performed retrospective descriptive study adult with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal transformed follicular referred T-cell therapy,...
Most patients with chronic myeloid leukemia (CML) treated tyrosine kinase inhibitors (TKIs) will relapse if treatment is withdrawn, but various trials have recently demonstrated that a significant proportion of who achieved stable and deep molecular response (DMR) can stop therapy without relapsing. However, most information on cessation was obtained from clinical strict recruiting criteria.We evaluated the outcome 25 CML discontinued TKI in our institute real-world practice.Of patients, 76%...
Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators leukemic cells vital to gain clinical insights into biology AML. Iron key extrinsic regulator cancer, but its systemic regulation remains poorly explored in To address this question, we studied iron metabolism patients AML at diagnosis mechanisms involved using syngeneic MLL-AF9-induced mouse model. We found that disorder unique...
We provide a real-world overview of multiple myeloma (MM) treatment patterns, outcomes and healthcare resource use (HRU) in Portugal.Data were collected retrospectively from consecutive patients diagnosed/treated at the Portuguese Oncology Institute Porto (IPO-Porto) between 2012 2015. Primary objectives progression-free survival (PFS) overall (OS), with patterns HRU secondary. Analysis was by line therapy (LOT), post hoc age (<65/≥65 years).165, 73 32 received first, second third LOTs...
Since its original description 2 decades ago, posterior reversible encephalopathy syndrome has been reported in children with several predisposing conditions. Epidemiologic data of hematologic malignancies is still scarce. Herein, we describe the clinical and radiologic features along outcome follow-up complicating treatment malignancies. Ten patients a median age 6.3 years were diagnosed syndrome. Six them undergoing chemotherapy remaining 4 at 37, 52, 78, 857 days after allogenic...
Therapy-related acute myeloid leukemia (t-AML) is a rare and almost always fatal late side effect of antineoplastic treatment involving chemotherapy, radiotherapy or the two combined. The present retrospective study intended to characterize t-AML patients that were diagnosed treated in single referral an oncological institution North Portugal. Over past 10 years, 231 cases AML at Portuguese Institute Oncology Porto, which 38 identified. Data regarding patient demographics, primary diagnosis...
The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was first CD38-targeting antibody showing be effective safe MM patients as monotherapy combination regimens, which its rapid implementation clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact patients’ quality life outcomes, decision should consider different factors weighted each patient individually....
Hemophagocytic syndrome is a rare and potentially fatal disorder characterized by pathological immune activation associated with primary familial disorder, genetic mutations, or occurring as sporadic condition. The latter can be secondary to infections, malignancies, autoimmune diseases. Clinically, patients present signs of severe inflammation, unremitting fever, cytopenias, spleen enlargement, phagocytosis bone marrow elements, hypertriglyceridemia, hypofibrinogenemia. Increased suspicion...
Objective: This was an observational retrospective study aimed to examine the frequency and associated factors of withdrawing or withholding life support (WWLS) in intensive care unit (ICU) a comprehensive cancer center. Methods: Medical records adult patients with admitted ICU between January 2010 December 2014 were reviewed. Patients who died during that period classified into 2 groups: full support. The relative impact demographic clinical assessed using logistic regression. Results: A...
Primary lymphoma of the urinary bladder is extremely rare. We present case a 67-year-old woman diagnosed with primary extranodal marginal zone mucosa-associated lymphoid tissue (MALT) bladder. The patient presented macroscopic hematuria. Renal ultrasound revealed solid vascularized mass, in inferior wall Pelvic computed tomography (CT) and magnetic resonance imaging (MRI) confirmed presence polypoid lesion on left side wall, measuring 40x45 mm, MRI study gadolinium that entire was involved....
Acute myeloid leukemia (AML) is a clonal hematological malignant condition and the implications of pretreatment risk criteria as predictive or prognostic factors are constantly under evaluation. With this study, authors' intent was to characterize AML patients evaluate clinical outcome associated with Southwestern Oncology Group (SWOG) coding criteria/cytogenetic score. Between 2002 2010, 225 were diagnosed at Portuguese Institute (Porto, Portugal). From patient group, 128 aged <65 years...
Abstract Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis and limited treatment strategies. Determining the role of cell-extrinsic regulators leukemic cells vital to gain clinical insights into biology AML. Iron key extrinsic regulator cancer but its systemic regulation remains poorly explored in To address this question, we studied iron metabolism AML patients at diagnosis mechanisms involved using syngeneic MLL-AF9-induced mouse model. We found that disorder...