A5004943097- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Indoor Air Quality and Microbial Exposure
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Air Quality and Health Impacts
- Biochemical Acid Research Studies
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Chromosomal and Genetic Variations
- Genomics and Rare Diseases
- Coenzyme Q10 studies and effects
- Erythrocyte Function and Pathophysiology
- Surgical Simulation and Training
- Veterinary Equine Medical Research
- Metabolism and Genetic Disorders
- Tendon Structure and Treatment
- HIV/AIDS drug development and treatment
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
- Plant Toxicity and Pharmacological Properties
- Genomic variations and chromosomal abnormalities
Hospital for Sick Children
2022-2024
Universidade do Porto
2009-2023
Hospital Israelita Albert Einstein
2018-2022
Brazilian Agricultural Research Corporation
2020
National Institute of Health Dr. Ricardo Jorge
2013
Institute of Biomedical Science
2011
Formaldehyde (FA) is a commonly used chemical in anatomy and pathology laboratories as tissue preservative fixative. Because of its sensitising properties, irritating effects cancer implication, FA accounts probably for the most important chemical-exposure hazard concerning this professional group. Evidence genotoxic carcinogenic properties humans insufficient conflicting, particularly regard to ability inhaled induce toxicity on other cells besides first contact tissues, such buccal nasal...
Abstract Raffinose family oligosaccharides (RFOs) are implicated in plant regulatory mechanisms of abiotic stresses tolerance and, despite their antinutritional proprieties grain legumes, little information is available about the enzymes involved RFO metabolism Fabaceae species. In present study, systematic survey legume proteins belonging to five key RFOs (galactinol synthase, raffinose stachyose alpha-galactosidase, and beta-fructofuranosidase) identified 28 coding-genes Arachis duranensis...
Abstract Formaldehyde (FA) is a world high-production compound with numerous applications ranging from production of resins to medicines. Due its sensitizing properties, irritating effects and potential cancer hazard FA great environmental health concern. Numerous studies in humans experimental animals demonstrated that inhaled produced toxicity, genotoxicity, at distal sites. IARC, based on sufficient data, reclassified as human carcinogen. The highest level exposure this aldehyde occurs...
Formaldehyde (FA) is a widely used industrial chemical for which exposure associated with nasopharyngeal and sinonasal cancer. Based on sufficient evidence of carcinogenicity from human investigations, supporting studies mechanisms underlying carcinogenesis, experimental in animals, FA status was recently revised reclassified as carcinogen. The highest level to occurs occupational settings. Although several reported ability induce genotoxic responses exposed workers, not all findings were...
Stem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair damaged or dysfunctional tissues organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded promising tool in because their several favorable properties such multipotency, high proliferation rate, helpful location, few associated ethical issues. These easily accessible nasal cavity most mammals, including rat, can be applied autologous treatments, do...
Tendon and ligament injuries are frequent in sport horses humans, such represent a significant therapeutic challenge. Tissue regeneration function recovery the paramount goals of tendon lesion management. Nowadays, several regenerative treatments being developed, based on use stem cell cell-based therapies. In present study, preparation equine synovial membrane mesenchymal cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization,...
Many studies have been dedicated to the development of scaffolds for improving post-traumatic nerve regeneration. The goal this study was assess effect on regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal stem cells isolated from Wharton's jelly umbilical cord, in peripheral reconstruction after crush injury. Chromosome analysis cell line carried out and no structural alterations were found metaphase. Chitosan membranes previously tested vitro,...
Fanconi Anemia (FA) is a rare genetic disorder, characterized by progressive bone marrow failure and increased predisposition to cancer. Despite being highly heterogeneous, all FA patients are hypersensitive alkylating agents, in particular 1,2:3,4-diepoxybutane (DEB), oxidative damage. Recent studies point defective mitochondria cells, which closely related with production of reactive oxygen species (ROS) concomitant depletion antioxidant defenses, glutathione well-known biomarker. The...
Red cell distribution width (RDW), a classical parameter used in the differential diagnosis of anemia, has recently been recognized as marker chronic inflammation and high levels oxidative stress (OS). Fanconi anemia (FA) is genetic disorder associated to redox imbalance dysfunctional response OS. Clinically, it characterized by progressive bone marrow failure, which remains primary cause morbidity mortality. Macrocytosis increased fetal hemoglobin, two indicators erythropoiesis, are...
Fanconi anaemia (FA) is a genetic cancer predisposition disorder associated with cytogenetic instability, bone marrow failure and pleiotropic cellular phenotype, including low thresholds of responses to oxidative stress, cross-linking agents selected cytokines. This study was aimed at defining the scope abnormalities in gene expression using publicly available FA Transcriptome Consortium (FTC) database (Gene Expression Omnibus, 2009 as GSE16334). We evaluated data set that included...
Robotic surgery is currently on the rise and has been widely applied all over world. Gynecology offers great opportunities for development of innovative techniques due to magnitude surgical needs. The aim this study was correlate perioperative complications, time, length hospital stay with diagnosis, procedure performed, surgeon experience in robot-assisted gynecological surgeries a 10-year period.This retrospective, transversal, cross-sectional involving 632 patients who underwent robotic...
Gastric cancer (GC) ranked as the fifth most incident in 2020 and third leading cause of mortality. Surgical prevention radio/chemotherapy are main approaches used GC treatment, there is an urgent need to explore discover innovative effective drugs better treat this disease. A new strategy arises with use repurposed drugs. Drug repurposing coupled drug combination schemes has been gaining interest scientific community. The objective project was evaluate therapeutic effects alternative GC....
Tendons and ligaments injuries are frequent in sport horses humans, representing a great therapeutic challenge. Tissue regeneration function recovery the paramount of tendon ligament lesions management. Nowadays, several regenerative treatments being developed, based on use stem cell cell-based therapies. In present study, preparation equine synovial membrane mesenchymal cells (eSM-MSCs) for clinical - collection, transport, isolation, differentiation, characterization, application is...
Abstract. The present study was designed to analyse the effect of red blood cells on T‐cell proliferation and expansion. A comparative done in peripheral cell cultures stimulated with phytohemagglutinin, or without cells. presence had a consistent enhancing T lymphocyte proliferation, as determined by an increase both mitotic index thymidine uptake. Phenotypic characterization blasts flow cytometry revealed that, cells, expanding were preferentially CD8 + Accordingly, lymphocytes from two...
To analyze the perioperative results and safety of performing gynecological surgeries using robot-assisted laparoscopy during implementation technique in a community hospital over 6-year period. This was retrospective observational study which medical records 274 patients who underwent robotic surgery from September 2008 to December 2014 were analyzed. We evaluated age, body mass index (BMI), diagnosis, procedures performed, American Society Anesthesiologists (ASA) classification, presence...
Fanconi anaemia (FA) is an inherited disorder characterized by chromosomal instability. The phenotype variable, which raises the possibility that it may be affected other factors, such as epigenetic modifications. These play important role in oncogenesis and pharmacologically manipulated. Our aim was to explore whether profiles FA differ from non-FA individuals these could manipulated alter disease phenotype. We compared expression of genes DNA methylation profile tumour suppressor between...
The most common audiologic manifestation in Fanconi anaemia (FA) was asymmetrical bilateral conductive hearing loss that more severe at lower frequencies and some cases had a progressive character. routine screening of all patients diagnosed with FA allowed the recognition mild prevention deleterious effects its progression adequate rehabilitation measures.FA is an autosomal recessive disease characterized by bone marrow failure, multiple congenital anomalies increased susceptibility to...