A5008849543- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Hemophilia Treatment and Research
- Palliative Care and End-of-Life Issues
- Gastric Cancer Management and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Atherosclerosis and Cardiovascular Diseases
- Hematopoietic Stem Cell Transplantation
- Thyroid and Parathyroid Surgery
- HER2/EGFR in Cancer Research
- Chronic Myeloid Leukemia Treatments
- Palliative and Oncologic Care
- Mesenchymal stem cell research
- Porphyrin Metabolism and Disorders
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
IPO Porto
2018-2022
Instituto Português de Oncologia Francisco Gentil
2021
Background Hermansky-Pudlak syndrome (HPS) is a rare inherited platelet disorder characterized by bleeding diathesis, oculocutaneous albinism (OCA) and myriad of often-serious clinical complications.Methods We established the laboratory phenotype genotype six unrelated pedigrees comprising ten patients with suspicion HPS; including aggregation, flow cytometry, dense granule content, electron microscopy high-throughput sequencing (HTS).Results The presentation showed significant heterogeneity...
Most of the palliative care (PC) patients have oncologic diseases, being hematologic tumors a small part them. According to literature, onco-hematologic (OH) should be individualized from those with solid for specialized required along their disease course. This study aims review casuistry OH referred PC in hospital and help understand better how hematologists can improve these patients.We analyzed all service 1 42 months, through consultation clinical files.A total 179 were reviewed (52.%...
A 63-year-old man presented to the emergency department with acute confusion and a 1-month history of frequent falls. Neurological examination revealed anisocoria, unresponsiveness light stimulation ophthalmoplegia in right eye. Brain computed tomography (CT) demonstrated mass at cranial base (Figure 1). Additionally, brain magnetic resonance imaging (MRI) an extensive infiltrative lesion, centered on clivus 2). biopsy left nasal fossa showed neoplasm consisting relatively small cells,...
Nonspecific idiopathic interstitial pneumonias (NSIP), commonly described as pneumonitis, have an extensive differential diagnosis. The introduction of new drugs to treat chronic lymphocytic leukemia (CLL) improved the therapeutic arsenal and prognosis. Idelalisib has been shown be effective in controlling CLL. An acute onset cough, dyspnoea, fever are pneumonitis main manifestations, establishing a diagnosis with viral bacterial respiratory infections [1-3]. A 67-year-old woman history CLL...
Chronic lymphocytic leukemia (CLL) is frequently an indolent diagnosis, with most of the patients being under surveillance for long time. There increased risk a second neoplasia in CLL, rarely hematological (in myeloid lineage even rarer). A 58-year-old male was diagnosed CLL 2012, remaining regular until 2014. Then, progressed, and 6 cycles rituximab, fludarabine, cyclophosphamide were prescribed partial response. He remained suffered 2 episodes autoimmune hemolytic anemia 2019. relapsed...
Abstract Multiple myeloma (MM) frequently affects kidney function through multiple mechanisms. Nonetheless, some patients develop injury due to other causes. A 54-year-old woman was diagnosed with IgG kappa MM developed IgA nephropathy without cast nephropathy. Further studies did not show criteria for progression or This case highlights the need further investigation of in (such as toxicity previous drugs, infectious events, immune-mediated disorders).
Acute porphyrias are a group of rare genetic metabolic disorders, caused by defect in one the enzymes involved heme biosynthesis, which results an abnormally high accumulation toxic intermediates. characterized potentially life-threatening attacks and, for some patients, chronic manifestations that negatively impact daily functioning and quality life. Clinical include nonspecific set gastrointestinal, neuropsychiatric, and/or cutaneous symptoms. Effective diagnostic methods widely available,...
In spite of existing profuse information regarding hemorrhagic complications hemophilia, literature is scarce towards the presence cancer in especially pediatric patients. There are still many uncertainties concerning these patients’ diagnosis and workup. We report here a rare case two severe aggressive diseases (neuroblastoma hemophilia A [HA]) concomitantly present same patient. highlight that HA did not have negative impact on patient’s oncologic course. This also illustrates significance...
Background: Acute digestive tract graft-versus-host disease (GI-GVHD) is a potential complication for patients receiving allogeneic hematopoietic stem cell transplants (HSCT). The burden and response to therapy rely on dynamic system: the cells (HSC) receptor characteristics (baseline degree of immune dysfunction, bone marrow microenvironment, gut microbiomes); HSC donor graft relative cellular composition. Aims: To retrospectively evaluate role reconstitution kinetics conventional...
Background: Acute leukemia relapse after allogeneic hematopoietic cell transplant (allo-HCT) is challenging. Allo-HCT a potentially curative treatment for acute myeloid (AML) and lymphoblastic (ALL). Extramedullary (EMR) can occur in various extramedullary tissues such as the central nervous system (CNS), breast, bone, testis, skin, data on EMR allo-HCT limited. long-term complication of stem transplantation with poor prognosis. Aims: To characterize setting allo-SCT AML ALL. Methods:...
Background: Allogenic stem cell transplant (alloSCT) has been used for several decades as a salvage strategy relapsed/ refractory Hodgkin lymphoma (R/R HL), being durable disease control method some patients. Methods: A unicenter retrospective analysis was performed about alloSCT in R/R HL along 21 years. survival made search prognostic factors with impact overall (OS)/progression free (PFS). Results: Thirty-five patients were reviewed: median age 30years [17-46], 57.1% males, 82.9% had an...
Despite the extensive information regarding hemophilia’s hemorrhagic complications, literature on cancer in hemophilia is scarce, especially pediatric patients. Many uncertainties remain concerning diagnosis and workup. We report a rare case of two severe diseases (neuroblastoma A (HA)) concomitantly present same patient. highlight that HA did not have negative impact patient’s oncologic course. This also illustrates significance cooperation among different specialties hospitals when caring for
Tyrosine kinase inhibitors are the standard treatment for Chronic Myeloid Leukemia. They have significantly improved response rate and global survival in long term CML patients, but also added relevant diverse toxicity. The authors report a clinical case of ocular toxicity connected to TKIs.
e19579 Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening hyperinflammatory syndrome, with challenging diagnosis (pediatric HLH-2004 criteria) treatment (HLH-1994 protocol). Recently, HScore has adapted these diagnostic criteria to the adult population. Malignancy-associated HLH (M-HLH) can occur as first manifestation of an unknown malignancy or after / during known cancer. This study evaluates features outcomes M-HLH in patients. Methods: Retrospective...