A5025271629- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Pharmaceutical studies and practices
- Dermatology and Skin Diseases
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
- Drug-Induced Adverse Reactions
- Head and Neck Cancer Studies
- Neonatal skin health care
- Autoimmune and Inflammatory Disorders
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Parvovirus B19 Infection Studies
- Sarcoma Diagnosis and Treatment
- Skin and Cellular Biology Research
- Vascular Tumors and Angiosarcomas
- Food Allergy and Anaphylaxis Research
- Soft tissue tumors and treatment
- Pregnancy and Medication Impact
- Hedgehog Signaling Pathway Studies
- Histiocytic Disorders and Treatments
Centre for Health Technology and Services Research
2022-2024
Universidade do Porto
2014-2024
Hospital de São João
2015-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2022
Research Center of Neurology
2016
Hospital Militar Principal
2011-2013
Faculdade de Medicina do ABC
2011
Hospitais da Universidade de Coimbra
2006
State Research Center for Dermatovenereology and Cosmetology
2003
Universidade Nova de Lisboa
2000
Erythroderma is an uncommon and severe dermatological manifestation of a variety diseases. It commonly challenging to find the underlying cause.The aim this study was analyze causes disease in patients with erythroderma.Data including clinical symptoms, laboratory examinations, histopathology follow-up information were collected from erythroderma admitted our department between 2000 2010.One-hundred three diagnosed identified during period (11.9% all hospitalized patients; hospital incidence...
Rowell syndrome is a rare distinctive entity first described in 1963 by and coworkers. It consists erythema multiforme-like lesions associated with lupus erythematosus. Zeitouni et al. recently redefined the major minor diagnostic criteria. Major criteria are erythematosus, speckled pattern of antinuclear antibody. Minor chilblains, positive anti-La (SS-B) or anti-Ro (SS-A) antibody reactive rheumatoid factor. We report case 63-year-old woman, no previous history who developed laboratory...
Atopic dermatitis (AD) is a difficult-to-treat inflammatory skin disease with high impact on patients' quality of life. Dupilumab, an IL-4 and IL-13 inhibitor, was the first monoclonal antibody approved for treatment moderate-to-severe AD currently in patients aged 6 or older.This nationwide, multicenter, retrospective, 48-week study designed by Portuguese Group to assess real-world efficacy safety dupilumab AD.A total 169 were enrolled, mean duration 22.75 (±11.98) years. The percentage...
Fabry disease (FD) is a rare X‐linked lysosomal storage disorder resulting from the deficient activity of enzyme α‐galactosidase A. Angiokeratomas (AKs) are frequent manifestation this disease. They usually become apparent during childhood and can cause important cosmetic disability. Current treatment feature in setting FD has been mainly based on application laser systems, namely argon laser, variable pulse width 532‐nm Nd:YAG 578‐nm copper vapor flashlamp‐pumped pulsed dye laser. We report...
Unilateral laterothoracic exanthem is a self-limited disease that occurs most commonly in children. It characterized by unilateral exanthem, often axillary region. The etiology unknown, but viral agent suspected. We report 1-year-old white girl with associated Epstein Barr virus infection, suggesting this has possible etiologic role.
Piebaldism is a rare disorder present at birth and inherited as an autosomal dominant trait. It results from mutation in the c-kit proto-oncogene associated with defect migration differentiation of melanoblasts neural crest. Clinical manifestations phenotypic severity strongly correlates site within KIT gene. Here we report 3-year-old boy his 33-year-old father leukoderma poliosis clinical criteria for Neurofibromatosis type 1. Genetic study both revealed p.Gly610Asp This familiar has not...
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a eruption that characteristically involves the or folds gluteal areas. We report case of 48-year-old woman with presence sharply demarcated erythema inferior cervical folds, axillae, area started 4 days after introduction telmisartan–hydrochlorothiazide administration to treat hypertension. Skin biopsy revealed dense perivascular periadnexal lymphohistiocytic infiltrate in superficial dermis, some eosinophils mast...
A 13-year-old boy, born prematurely and hypotonic, from non-consanguineous healthy parents, was referred to our department because of easy bruising. slightly extensible, thin translucent skin, associated with dysmorphic facies, acrogeria, multiple ecchymoses, hypermobility the small joints, dorsal kyphosis, genu valgum, flat feet, elongated upper limbs, low muscle tone were all evident. history learning disability bilateral inguinal hernia present. Blood imaging studies unremarkable. skin...
We report the case of a 12-year-old girl presenting at birth with erythroderma, erosions and blisters scattered over integument. By age 3 she presented generalized hyperkeratotic plaques cobblestone pattern pungent odour, most prominently around flexures, scalp palmoplantar areas. Clinical, histological ultrastructural findings confirmed diagnosis epidermolytic hyperkeratosis (EHK). Molecular genetic analysis revealed mutation in KRT10 gene. Treatment oral acitretin was attempted but it...
Abstract We report a 12‐month‐old boy with skin eruption that developed 15 days after receiving the measles, mumps, rubella (MMR), pneumococcal, and meningococcal vaccines, consistent diagnosis of Wells syndrome. Patch testing showed positive reaction to gelatin, which is used as stabilizer for both live inactivated vaccines. Gelatin was only present in MMR vaccine.
A 56-year-old white woman developed a distinctive skin eruption over her mammary, lumbosacral, and pubic areas 2 weeks after the start of esomeprazole therapy for dyspeptic symptoms. Skin biopsy disclosed spongiotic dermatitis with predominantly lymphocytic dermal infiltrate. Treatment tapering dose corticosteroid withdrawal suspected drug led to rapid resolution without residual dyschromia. Patch testing 2% in petrolatum was negative at 48 72 hours but became positive on day 6....
We report a 45-year old man who developed maculopapular exanthema on the inferior cervical folder, axillae and umbilicus, as well erythema multiforme-like lesions wrists after introduction in his work of pao ferro (Machaerium scleroxylon). Patch tests were positive to ebony. This case highlights importance patch for confirmation culprit agent occupational dermatoses also identify other allergens that patient should avoid. Tropical woods contain quinones could explain possible cross-reactions...
Atopic dermatitis is a highly prevalent chronic, immune-mediated inflammatory skin disease with significant burden on patients, families and healthcare systems. This article presents recommendations developed by the Dermatitis Group of Portuguese Society Dermatology Venereology addressing several clinical questions that arise in management care moderate-to-severe atopic biologic agents Janus kinase (JAK) inhibitors based available evidence. The were generated after thorough evaluation...
A 43-year-old female with antiphospholipid syndrome and Graves' disease developed a cutaneous leukocytoclastic vasculitis associated antineutrophil cytoplasmic antibody (ANCA) against myeloperoxidase (MPO-ANCA) proteinase-3 (PR3-ANCA), whilst treated propylthiouracil (PTU). The skin lesions were progressively resolved after withdrawal of PTU treatment oral steroids. Patch testing at 1%, 5%, 10% in petrolatum was positive 48 h. Despite ANCA titers 1 year follow-up, the patient maintains...
Acute hemorrhagic edema (AHE) is an uncommon self-limited disorder affecting young children triggered by infection, drugs, or immunization. A 2-year-old boy was observed due to sudden onset of painful and edematous purpuric papular plaque lesions the face upper extremities that started 2 weeks after H1N1 The patient also developed exuberant on dorsum hands. Complete blood count, biochemistry, urinalysis results were normal. Histopathological examination revealed perivascular periadnexial...