A5073799733- Health Systems, Economic Evaluations, Quality of Life
- Hemophilia Treatment and Research
- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Psoriasis: Treatment and Pathogenesis
- Sulfur Compounds in Biology
- Blood Coagulation and Thrombosis Mechanisms
- Orthopedic Surgery and Rehabilitation
- Glutathione Transferases and Polymorphisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adolescent and Pediatric Healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Child and Adolescent Psychosocial and Emotional Development
- Healthcare Policy and Management
- Diabetes Management and Education
- Occupational Health and Safety Research
- Statistical Methods in Clinical Trials
- Folate and B Vitamins Research
- Platelet Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Social and Educational Sciences
- Global Health Care Issues
- Chronic Myeloid Leukemia Treatments
- Dermatology and Skin Diseases
Lund University
2016-2025
Swedish Institute for Health Economics
2015-2025
Malmö University
2003-2024
Trinity College Dublin
2022
Skåne University Hospital
2011-2017
Medicon Village
2017
Institute of Health Economics
1999-2016
Karolinska University Hospital
2003-2012
Karolinska Institutet
1978-2012
Swedish Institute
2009-2011
Objective To validate diagnostic codes for psoriasis and psoriatic arthritis (PsA) estimate physician-diagnosed prevalence of PsA in the Skåne region, Sweden. Methods In Healthcare Register (SHR), all healthcare consultations are continuously collected inhabitants region (population 1.2 million). During 2005–2010 we identified individuals with ≥1 physician-consultations consistent (ICD-10). Within this group also those diagnosed PsA. We performed a validation by reviewing medical records 100...
Patients with injured hands and forearms of varying severity [Hand Injury Severity Score (HISS)] were studied prospectively, including analysis costs, hand/arm function (DASH), health status (SF-36). Costs, duration sick-leave, DASH-score (high score; impaired function) increased by injury (higher HISS) the greatest proportion total costs resulted from lost production. Most employed patients returned to work within a year, but even minor injuries expensive. HISS care during an emergency...
This study analysed the costs of median and ulnar nerve injuries in forearm humans factors affecting such costs. The within health-care sector lost production were calculated 69 patients with an injury to and/or forearm, usually caused by glass, a knife, or razorblade. Factors associated variation outcome analysed. total for employed person EUR 51,238 31,186, respectively, 87% due loss production. All higher concomitant tendon (4 tendons). also who changed work after if both nerves injured....
Abstract Background To study costs and outcome for serious hand arm injuries during the first year after trauma. Methods In patients with a Hand Injury Severity Score (HISS) > 50, DASH EQ-5D scores as well factors related to within health care sector, due lost production total were evaluated. Cox-regression analysis stratifying mechanism of injury was used analyse return work. Results The majority 45 included (median 42 years 16–64) men severe (n = 9) or major 36) different type...
Epidemiology, results of treatment, impact on activity daily living (ADL), and costs for treatment digital nerve injuries have not been considered consistently. Case notes patients 0–99 years age in Malmö municipality, Sweden, who presented with a injury were referred to the Department Hand Surgery 1995–2005 analysed retrospectively. The incidence was 6.2/100 000 inhabitants year. Most commonly men (75%; median 29 years) injured. Isolated concomitant tendon equally common. direct (hospital...
Abstract Aims/hypothesis The risk of complications and medical consequences type 2 diabetes are well known. Hospital costs have been identified as a key driver total in studies the economic burden diabetes. Less evidence has generated on impact individual diabetic overall societal burden. objective this study was to analyse hospital-based healthcare (inpatient outpatient care) work absence related macrovascular microvascular Sweden 2016. Methods Data for 2016 were retrieved from Swedish...
Summary. Using an 11‐year panel of 156 Norwegian and Swedish patients with severe haemophilia, including retrospective case‐book data from birth, we compared the differences in haemophilia‐related resource use between on‐demand prophylactic treatment. Patients treated had more surgery (arthrodeses, prostheses implantations synovectomies) days lost work. Median annual factor‐concentrate consumption among adults (18+) was 211 000 IU [interquartile range (IQR) 154 000–268 000] or 3 024 kg −1...
As moderate to severe psoriasis is a systemic disease with large effects on health-related quality of life, generic measures that include overall health, not only skin involvement, are necessary. Knowledge about the relationship between preference-based EuroQol 5D (EQ-5D) and dermatology-specific in limited.To analyse EQ-5D, Dermatology Life Quality Index (DLQI) Psoriasis Area Severity (PASI) patients Swedish clinical practice by demographic characteristics, compare EQ-5D among vs....
In the two European Union (EU)-funded projects, PCM4EU (Personalized Cancer Medicine for all EU citizens) and PRIME-ROSE (Precision Repurposing System Using Pragmatic Clinical Trials), we aim to facilitate implementation of precision cancer medicine (PCM) in Europe by leveraging experience from ongoing national initiatives that have already been particularly successful.
ABSTRACT Introduction Comorbidities and public health conditions in haemophilia are receiving increasing attention. Aim To analyse the prevalence of comorbidities mortality people with (PwH) compared to matched controls subgroups (factor consumption sex). Methods This study used longitudinal individual‐level data (11 years) from national registers three Nordic countries (Denmark, Finland Sweden) MIND (NCT03276130) for PwH (1:5 on birth year It arthropathy, human immunodeficiency virus (HIV),...
Background Health-economic models of diabetes are complex since the disease is chronic, progressive and there many diabetic complications. External validation these helps building trust satisfies demands from decision makers. We evaluated external validity IHE Cohort Model Type 2 Diabetes; impact using alternative macrovascular risk equations; compared results to those microsimulation models. Methods The model was analysed 12 clinical trials observational studies by comparing 167 predicted...
Summary Regular replacement therapy (prophylaxis) for haemophilia has been shown to prevent development of disabling arthropathy and provide a better quality life compared treatment on demand; however, at substantially higher cost. Calculations based pharmacokinetic principles have that shortening dose intervals may reduce The aim this prospective, randomized, crossover pilot study was address whether daily dosing is feasible, if it reduces concentrate consumption as effective in preventing...
<b><i>Background:</i></b> Although clinical studies have shown efficacy of biological agents in moderate to severe psoriasis, observational real-world effectiveness are rare. <b><i>Objective:</i></b> To analyse the psoriasis area and severity index (PASI) quality life by EQ-5D questionnaire dermatology (DLQI) patients who switched from conventional systemic treatment practice. Furthermore, patient groups with highest benefit agents....
The epidemiology and costs of repair rehabilitation zone II flexor tendon injuries in 135 patients from the southern part Sweden were analysed. little finger was most frequently injured (43%), usually with a knife (46%), 30% work related. Total median within health-care sector for SEK 48,500 (1 EURO=9.23 SEK, 4/1/2002). Costs other sectors 93,000. Active mobilization or rubber band traction increased (SEK 7400 6000, respectively) but improved range movement (5-7%). Immobilization had higher...
To compare two different regimens for children diagnosed with type 1 diabetes: hospital-based care or home (HBHC), referring to specialist in a home-based setting. The trial took place Sweden randomized controlled design and included 60 children, aged 3-15 years. After 2-3 days care, were either continued HBHC 6 days. primary outcome was the child's metabolic control after 2 Secondary outcomes set evaluate family child situation as well healthcare services. This article presents data months...
BackgroundLifestyle interventions affect patients' risk factors for metabolic syndrome (MeSy), a pre-stage to cardiovascular diseases, diabetes and related complications. An effective lifestyle intervention is the Swedish Björknäs intervention, 3-year randomized controlled trial in primary care MeSy patients. To include future disease-related cost health consequences cost-effectiveness analysis, simulation model was used estimate short-term (3-year) long-term (lifelong) of study....
Background Randomised controlled trials have demonstrated substantial clinical benefit for thrombectomy in patients with acute ischaemic stroke and proximal anterior circulation arterial occlusion. Aim We investigated the long-term cost-effectiveness of after thrombolysis versus alone using real-world outcome data on need health care, home help nursing care. Methods used real-life resource use survival from Swedish Stroke Register pooled outcomes five randomised published 2015 a newly...
Background To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction. Methods 121 young, active adults with ACL injury to a previously uninjured knee were randomised reconstruction (n=62, within 10 weeks injury) or (n=59; 30 6–55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave obtained from regional national registers. Costs quality-adjusted years...
Abstract Introduction People with haemophilia (PwH) may experience symptoms of haemophilia‐related pain, depression or anxiety, which can negatively impact health‐related quality life. Aim To obtain the perspective PwH and treaters from Sweden, Finland Denmark on management anxiety using cross‐sectional survey data MIND study (NCT03276130). Methods their caregivers completed a about experiences related to haemophilia, standard EQ‑5D‐5L instrument. Five investigators at treatment centres...
Individuals with type 2 diabetes (T2D) are at high risk of experiencing atherosclerotic cardiovascular disease (ASCVD), which is associated morbidity, mortality and healthcare resource utilisation. Clinical guidelines recommend the use glucose-lowering medications benefits in individuals T2D disease, but there evidence that this not reflected clinical practice. We used linked national registry data from Sweden to compare outcomes people ASCVD against matched controls without ASCVD, over 5...