A5047724241- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Lipoproteins and Cardiovascular Health
- Economic and Financial Impacts of Cancer
- Healthcare Policy and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Disease Management Strategies
- Multiple Sclerosis Research Studies
- Muscle Physiology and Disorders
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Primary Care and Health Outcomes
- Coronary Interventions and Diagnostics
- Diabetes Management and Research
- Diabetes Management and Education
- Business Strategy and Innovation
- Schizophrenia research and treatment
- Heart Failure Treatment and Management
- Innovation Policy and R&D
- Social and Educational Sciences
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rheumatoid Arthritis Research and Therapies
- Cardiac Health and Mental Health
- Global Health Care Issues
- Multiple and Secondary Primary Cancers
Karolinska Institutet
2015-2024
Swedish Institute for Health Economics
2015-2024
École Supérieure des Sciences Économiques et Commerciales
2023
CY Cergy Paris Université
2023
IRCCS Materno Infantile Burlo Garofolo
2023
University of Trieste
2023
University of York
2023
University of Maryland, College Park
2023
Tampere University
2022
Aarhus University
2022
Guidelines and Expert Consensus documents aim to present management recommendations based on all of the relevant evidence a particular subject in order help physicians select best possible strategies for individual patient, suffering from specific condition, taking into account not only impact outcome, but also risk benefit ratio diagnostic or therapeutic procedure. The ESC guidelines production can be found website†. In brief, appoints experts field carry out comprehensive critical...
Cancer care is evolving rapidly, and costs value of new treatments are frequently debated. Up-to-date evidence on the total cost cancer needed to inform policy decisions. This study estimates in Europe 2018 extends a previous analysis for 1995-2014.Cancer-specific health expenditure were derived from national estimates. Data drug sales obtained IQVIA. The productivity loss premature mortality was estimated data Eurostat World Health Organization. Estimates morbidity informal based...
To estimate costs of admission and incurred on an annual basis by patients with atrial fibrillation (AF) in Greece, Italy, Poland, Spain, the Netherlands.The Euro Heart Survey AF enrolled 5333 35 European countries 2003 2004. This was a bottom-up cost study conducted for five largest contributors terms enrolled. Quantities resource use during enrolment 1-year follow-up were inferred from survey data multiplied national unit order to per patient associated each country. Mean inpatient...
The objective of this study was to estimate the total cost illness and economic burden Duchenne muscular dystrophy (DMD).Patients with DMD from Germany, Italy, United Kingdom, States were identified through Translational Research in Europe-Assessment & Treatment Neuromuscular Diseases registries invited complete a questionnaire online together caregiver. Data on health care use, quality life, work status, informal care, household expenses collected costs perspective society caregiver...
The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab has been demonstrated to reduce the composite of myocardial infarction, stroke, or cardiovascular death in patients with established atherosclerotic disease. To our knowledge, long-term cost-effectiveness this therapy not evaluated using clinical trial efficacy data.To evaluate disease when added standard background therapy.A Markov cohort state-transition model was used, integrating US population-specific demographics,...
Duchenne muscular dystrophy (DMD) is a rare pediatric neuromuscular disease associated with progressive muscle degeneration and extensive care needs. Our objective was to estimate the caregiver burden DMD. We made cross-sectional assessments of health-related quality life (HRQL) using EuroQol EQ-5D, Visual Analogue Scale (VAS), SF-12 Health Survey, Zarit Caregiver Burden Interview (ZBI) administered online. Results were stratified by stage (early/late ambulatory/non-ambulatory) caregivers'...
To estimate health-related quality of life (HRQOL) in patients with Duchenne muscular dystrophy (DMD).HRQOL was assessed using the Health Utilities Index Questionnaire (HUI) and Pediatric Quality Life Inventory (PedsQL) neuromuscular module version 3.0 online. Results were stratified by disease stage (early/late ambulatory/non-ambulatory) caregivers' perceptions patients' health mental status.A total 770 patient-caregiver pairs (173 German, 122 Italian, 191 UK, 284 USA) participated. Most...
In October 2018, evolocumab was made available at a reduced annual list price of $5850 in the United States. This 60% reduction aimed improving patient access by lowering copays. Shortly thereafter, 2018 American College Cardiology/American Heart Association cholesterol management guideline released. An updated cost-effectiveness analysis States may be therefore interest to payers and prescribers.
Two simulation models were developed to analyze the cost-effectiveness of new treatments that affect progression rheumatoid arthritis (RA).We used data from 2 cohorts patients with early RA who had been followed up since disease onset (up 15 years). In Swedish study, 183 for a mean 11.3 years. UK 916 7.8 Disease over 10 years was modeled as annual transitions between states, defined by Health Assessment Questionnaire (HAQ) scores. A regression model estimate transition probabilities...
Background: International care guidelines for Duchenne muscular dystrophy (DMD) were published in 2010, but compliance clinical practice is unknown. Objective: The objective of our study was to compare real-world DMD Germany, Italy, the UK
Abstract Aims/hypothesis The risk of complications and medical consequences type 2 diabetes are well known. Hospital costs have been identified as a key driver total in studies the economic burden diabetes. Less evidence has generated on impact individual diabetic overall societal burden. objective this study was to analyse hospital-based healthcare (inpatient outpatient care) work absence related macrovascular microvascular Sweden 2016. Methods Data for 2016 were retrieved from Swedish...
Objectives: The Finnish Diabetes Prevention Study (DPS) was a randomized intervention program that evaluated the effect of intensive lifestyle modification on development diabetes mellitus type 2 in patients with impaired glucose tolerance. As such, is demanding terms resources; it necessary to assess whether would be money well spent. This determination purpose this study. Methods: We developed simulation model economic consequences an like one studied DPS Swedish setting. used data from...
When treatments with the potential to change natural history of a disease are introduced, their longer-term effect on costs and quality life (utility) has be estimated using economic models. However, remain useful tools, models must updated when new information becomes available. Our earlier in rheumatoid arthritis (RA) have been based functional status, but it recently shown that activity might an independent utility. The objective this study was improve model by incorporating subjective...
Abstract Aims To determine the prevalence and incidence of Type 2 diabetes its complications in Uppsala county, Sweden between 1996 2003. Methods Retrospective population‐based study patients with identified computerized medical records at 26 county primary care centres. Prevalence were estimated population aged 30–39, 40–49, 50–59, 60–69, 70–79 ≥ 80 years. Mortality, determined through linkage to national inpatient, uraemia cause‐of‐death registers. Results Crude increased from 2.2 3.5% In...
Summary. The amount of catechols secreted from the adrenal glands concomitant with activation sympathetic vasodilator outflow by hypothalamic stimulation was studied in 14 cats. Blood samples left vein were collected during control and periods, tested (rat uterus rat colon) after separating adrenaline noradrenaline paper chromatography. mean values for output those taken area 0.06 0.32 μg/kg/min (increase 433 per cent). corresponding figures 0.19 0.35 84 As will be seen these increase...
Introduction Alzheimer's disease (AD) is a chronic and progressive neurodegenerative that places substantial burden on patients caregivers. Aducanumab the first AD therapy approved by US Food Drug Administration to reduce defining pathophysiological feature of disease, brain amyloid plaques. In phase 3 clinical trial EMERGE (NCT02484547), aducanumab reduced decline in with mild cognitive impairment (MCI) due dementia confirmed pathology. Methods We used Markov modeling approach predict...