Sotrovimab, a recombinant human monoclonal antibody (mAb) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had US Food and Drug Administration Emergency Use Authorization for the treatment of high-risk outpatients with mild-to-moderate disease 2019 (COVID-19) from 26 May 2021 to 5 April 2022. Real-world clinical effectiveness sotrovimab in reducing risk 30-day all-cause hospitalization and/or mortality was evaluated period when prevalence circulating SARS-CoV-2 variants...

The objective of this study was to estimate the total cost illness and economic burden Duchenne muscular dystrophy (DMD).Patients with DMD from Germany, Italy, United Kingdom, States were identified through Translational Research in Europe-Assessment & Treatment Neuromuscular Diseases registries invited complete a questionnaire online together caregiver. Data on health care use, quality life, work status, informal care, household expenses collected costs perspective society caregiver...

Duchenne muscular dystrophy (DMD) is a rare pediatric neuromuscular disease associated with progressive muscle degeneration and extensive care needs. Our objective was to estimate the caregiver burden DMD. We made cross-sectional assessments of health-related quality life (HRQL) using EuroQol EQ-5D, Visual Analogue Scale (VAS), SF-12 Health Survey, Zarit Caregiver Burden Interview (ZBI) administered online. Results were stratified by stage (early/late ambulatory/non-ambulatory) caregivers'...

To estimate health-related quality of life (HRQOL) in patients with Duchenne muscular dystrophy (DMD).HRQOL was assessed using the Health Utilities Index Questionnaire (HUI) and Pediatric Quality Life Inventory (PedsQL) neuromuscular module version 3.0 online. Results were stratified by disease stage (early/late ambulatory/non-ambulatory) caregivers' perceptions patients' health mental status.A total 770 patient-caregiver pairs (173 German, 122 Italian, 191 UK, 284 USA) participated. Most...

Before the introduction of immunomodulatory therapies for multiple sclerosis (MS), treatment options MS consisted symptomatic management (physical therapy and pharmacological symptom management). Symptomatic has been supplemented in past decade by 2 new classes that have approved as first-line treatments relapsing-remitting (RRMS): subcutaneous glatiramer acetate (SC GA) 3 beta-interferons: intramuscular interferon beta-1a (IM IFNbeta-1a), SC IFNbeta-1a, IFNbeta-1b.To estimate economic...

Background: International care guidelines for Duchenne muscular dystrophy (DMD) were published in 2010, but compliance clinical practice is unknown. Objective: The objective of our study was to compare real-world DMD Germany, Italy, the UK

Results from clinical trials in patients with severe eosinophilic asthma have demonstrated that mepolizumab is well tolerated and associated improved control as evidenced by reductions both exacerbations maintenance oral corticosteroid use, improvements lung function, control, quality of life. However, real-world data are lacking on the impact treatment.To assess effect treatment rate exacerbation-related costs a setting.This retrospective cohort study (GSK ID: 209017; HO-18-19168) analyzed...

To describe outcomes of high-risk patients with coronavirus disease 2019 (COVID-19) treated sotrovimab, other monoclonal antibodies (mAbs), or antivirals, and who did not receive early COVID-19 treatment. We also evaluate the comparative effectiveness sotrovimab versus no treatment in preventing severe clinical outcomes.

Introduction.—Although research suggests that early treatment of migraine headache when the pain is mild results in better outcomes for patients, many patients delay taking their acute‐migraine medication until headaches are moderate or severe. Understanding and why use medications an important first step to improve management. Methods.—A prospective observational study, conducted at a major national retail pharmacy chain with stores across United States between April 2001 November 2002,...

Abstract Background Gabapentin enacarbil ( GE n), a transported prodrug of gabapentin, provides sustained, dose‐proportional gabapentin exposure. The purpose this study was to investigate the dose response n select optimal dose(s) for clinical use in subsequent diabetic peripheral neuropathy DPN ) trials. Methods This multicenter, randomized, double‐blind, double‐dummy, parallel group, placebo‐controlled trial with duration approximately 20 weeks Clinicaltrials.gov database, Identifier ! NCT...

Asthma and COPD have overlapping characteristics. As there are limited data on whether asthma-COPD overlap (ACO) represents a distinct condition, this study aimed to determine the similarities differences of ACO with asthma COPD.US population-based, cross-sectional using National Health Nutrition Examination Survey (2009-2012) compared participants vs those or COPD, each as mutually exclusive disease states. Demographics, health status, disability/limitations, care resource utilization,...

Examine the impact of migraine on work productivity, and particularly association between time onset lost productivity as measured by absenteeism presenteeism.A total 509 people with completed one online baseline survey a diary after each their next three migraines. All subjects were 18 or older employed full time.Sixty-four percent migraines occurred workday. Of these, 68% resulted in some form presenteeism. Migraines occurring during usual sleeping hours prior to start had greatest...

Approximately 33-50% of patients with systemic lupus erythematosus (SLE) develop organ damage within 5 years diagnosis. Real-world studies that capture the healthcare resource utilization (HCRU) and costs associated SLE-related are limited. The aim this study was to evaluate HCRU in SLE USA.This retrospective (GSK 208380) used PharMetrics Plus administrative claims database from 1 January 2008 30 June 2019. Patients were identified using International Classification Diseases (ICD)-9/10 codes...

A Duchenne muscular dystrophy (DMD) cohort was identified using a claims-based algorithm to estimate health care utilization and costs for commercially insured DMD patients in the United States. Previous analyses have used broad diagnosis codes that include range of types as proxy burden DMD.To DMD-associated resource sample via codes, pharmacy prescriptions, procedure unique management based on clinical milestones.DMD were selected from claims database (2000-2009). Patients with suggestive...

Purpose: Based on blood and sputum samples, up to 40% of patients with COPD have eosinophilic inflammation; however, there is little epidemiology data characterizing the health care burden within this sub-population. Given that COPD-attributable medical costs in USA are predicted approach $50 billion by 2020, we analyzed effect eosinophil counts exacerbations resource utilization costs. Patients methods: This cross-sectional study used electronic records insurance claims from Reliant Medical...

To estimate the prevalence and associated disease burden of eosinophilic granulomatosis with polyangiitis (EGPA) in patients asthma from a US claims database.Two cohorts were defined using enrollees (aged ≥18 years) Optum deidentified Clinformatics Datamart database 2010-2014, based on validated EGPA case definitions varying specificity: 1 (main cohort; more specific; 2 codes [in any combination] within 12 months each other for eosinophilia, vasculitis, or mononeuritis multiplex)...

Background: In controlled clinical studies, mepolizumab has been shown to reduce exacerbation rates and the use of oral corticosteroids as well improve asthma control health-related quality life compared with placebo in patients severe eosinophilic asthma. However, real-world data on impact outcomes are limited. Objective: To evaluate effect exacerbations exacerbation‐related costs U.S. practice. Methods: This retrospective cohort study used administrative claims from ages ≥12 years at...

Glucocorticoids are part of standard therapy for systemic lupus erythematosus (SLE), despite adverse effects associated with long-term treatment. Belimumab improved clinical manifestations SLE and reduced glucocorticoid doses in trials practice; however, associations have not been examined using multi-institutional electronic health record (EHR) data. Using the Rheumatology Informatics System Effectiveness registry, we use patterns among belimumab-treated adults SLE.This retrospective...

Objective Assess healthcare costs associated with systemic lupus erythematosus (SLE) flares among patients and without nephritis (LN). Methods This retrospective cohort study used medical pharmacy claims data from the United States-based Optum Clinformatics database to identify adults SLE between 1 January 2016, 31 December 2018. Index was date of a patient’s earliest diagnosis claim during identification period. Patients were categorized based on ICD-9/-10 codes into one two cohorts: LN...

BACKGROUND: Risk of recurrent cardiovascular events following an initial cardiovascular-related hospitalization remains high despite available interventions. Rates as well associated health care resource utilization and costs are needed to assess the value treatments. OBJECTIVE: To quantify, in patients with previous for acute coronary syndrome (ACS), rates nonfatal major adverse (MACE) secondary (SCE), a first MACE. METHODS: Administrative data from large population commercial managed...