A5032690231- Health Systems, Economic Evaluations, Quality of Life
- Economic and Environmental Valuation
- Pharmaceutical Economics and Policy
- Venous Thromboembolism Diagnosis and Management
- Healthcare Policy and Management
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Global Health Care Issues
- Healthcare cost, quality, practices
- Cardiac Valve Diseases and Treatments
- Delphi Technique in Research
- Schizophrenia research and treatment
- Acute Ischemic Stroke Management
- Meta-analysis and systematic reviews
- Antiplatelet Therapy and Cardiovascular Diseases
- Autism Spectrum Disorder Research
- Bone health and osteoporosis research
- Sepsis Diagnosis and Treatment
- Mental Health Treatment and Access
- Infective Endocarditis Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Hip and Femur Fractures
- Workplace Health and Well-being
- Cardiac Imaging and Diagnostics
University of Sheffield
2015-2024
Open Group
2024
Open University of the Netherlands
2023
Ibero American University
2017
Amgen (United States)
2017
Pharmerit (Netherlands)
2008-2009
University Medical Center Utrecht
2003-2008
Université Paris Cité
2008
Utrecht University
2001-2008
Erasmus University Rotterdam
1993-2004
A new version of the EQ-5D, EQ-5D-5L, is available. The aim this study to produce a value set support use EQ-5D-5L data in decision-making. design followed an international research protocol. Randomly selected members English general public completed 10 time trade-off and 7 discrete choice experiment tasks face-to-face interviews. 20-parameter hybrid model was used combine generate values for 3,125 health states. Valuation are available 996 respondents. Face validity has been demonstrated,...
AimsTo critically review the available transcatheter aortic valve implantation techniques and their results, as well propose recommendations for use development.
To critically review the available transcatheter aortic valve implantation techniques and their results, as well propose recommendations for use development.A committee of experts including European Association Cardio-Thoracic Surgery Society Cardiology representatives met to reach a consensus based on analysis data obtained with own experience. The evidence suggests that this technique is feasible provides haemodynamic clinical improvement up 2 years in patients severe symptomatic stenosis...
Previous studies have shown that among patients undergoing multivessel revascularization, coronary-artery bypass grafting (CABG), as compared with percutaneous coronary intervention (PCI) either by means of balloon angioplasty or the use bare-metal stents, results in greater relief from angina and improved quality life. The effect PCI drug-eluting stents on these outcomes is unknown.
Background Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel disease enrolled in Arterial Revascularization Therapy Study (ARTS) trial determine costs these 2 strategies. Methods Results Patients (n=1205) randomly assigned stent implantation (n=600; diabetic, 112) or CABG (n=605; 96). Costs per patient calculated as product each patient’s use resources corresponding unit costs. Baseline characteristics similar...
To assess the cost-effectiveness of drotrecogin alfa (activated) therapy, which was recently shown to reduce mortality in severe sepsis.Estimates effectiveness and resource use were based on data collected prospectively as part a multicenter international trial. Estimates hospital costs subset patients treated United States (33% all enrolled patients). Lifetime projections modeled from published sources tested sensitivity analyses. Analyses conducted societal perspective, limited healthcare...
To critically review the available transcatheter aortic valve implantation techniques and their results, as well propose recommendations for use development.A committee of experts including European Association Cardio-Thoracic Surgery Society Cardiology representatives met to reach a consensus based on analysis data obtained with own experience. The evidence suggests that this technique is feasible provides haemodynamic clinical improvement up 2 years in patients severe symptomatic stenosis...
The proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab has been demonstrated to reduce the composite of myocardial infarction, stroke, or cardiovascular death in patients with established atherosclerotic disease. To our knowledge, long-term cost-effectiveness this therapy not evaluated using clinical trial efficacy data.To evaluate disease when added standard background therapy.A Markov cohort state-transition model was used, integrating US population-specific demographics,...
Background. Preference elicitation techniques such as time trade-off (TTO) and standard gamble (SG) receive criticism for their complexity difficulties of use. Ordinal discrete choice experiment (DCE) are arguably easier to understand but generate values that not anchored onto the full health-dead 1-0 quality-adjusted life-year (QALY) scale required use in economic evaluation. Methods. This article compares existing methods converting modeled DCE latent QALY scale: 1) anchoring using dead...
Three EQ-5D value sets (EQ-5D-3L, crosswalk, and EQ-5D-5L) are now available for cost-utility analysis in the UK and/or England. The sets' characteristics differ, it is important to assess implications of these differences. aim this paper compare three sets. We carried out comparing predicted values from each set, investigated how differences health on descriptive system reflected utility score by assessing adjacent states. also assessed using data patients who completed both EQ-5D-3L...
In October 2018, evolocumab was made available at a reduced annual list price of $5850 in the United States. This 60% reduction aimed improving patient access by lowering copays. Shortly thereafter, 2018 American College Cardiology/American Heart Association cholesterol management guideline released. An updated cost-effectiveness analysis States may be therefore interest to payers and prescribers.
Summary: Purpose : The relationship between seizure frequency and both health care costs quality of life (QOL) was investigated in a retrospective, cross‐sectional, multicenter study France, Germany, the United Kingdom. Methods Three hundred outpatients with stable partial epilepsy were approximately evenly distributed among five seizure—frequency groups, ranging from seizure—free last 3 months (group 1) to daily seizures 5). Economic data, obtained through patient interviews record...
Value sets for the EQ-5D-5L are required to facilitate its use in estimating quality-adjusted life years. An international protocol has been developed guide collection of stated preference data this purpose and used generate valuation England. The aim paper is report innovative methods modelling those obtain a value set. Nine hundred ninety-six members English general public completed time trade-off (TTO) discrete choice experiment (DCE) tasks. We estimate models, with without interactions,...
Background —Coronary stenting improves outcomes compared with balloon angioplasty, but it is costly and may have other disadvantages. Limiting stent use to patients a suboptimal result after angioplasty (provisional angioplasty) be as effective less expensive. Methods Results —To analyze the cost-effectiveness of provisional scheduled for single-vessel were first randomized receive primary (97 patients) or guided by Doppler flow velocity angiography (523 patients). Patients in latter group...
ABSTRACT ‘Lead Time’ TTO improves upon conventional by providing a uniform method for eliciting positive and negative values. This research investigates (i) the values generated from different combinations of time in poor health full health; order which these appear (lead vs. lag); (ii) whether concur with participants' views about states; (iii) methods handling extreme preferences. n = 208 participants valued five EQ‐5D states, using two four variants. Combinations lead state duration were:...
Little is known about the quality of life following pulmonary embolism (PE). The aim study was to assess 12-month illness burden in terms health-related (HrQoL) and mortality, relation differences patient characteristics.The PREFER VTE registry, a prospective, observational conducted seven European countries, used. Within 2 weeks an acute symptomatic PE, patients were recruited followed up for 12 months. Associations between characteristics HrQoL (EQ-5D-5L) mortality examined using...
Abstract Objectives: To evaluate the cost‐effectiveness of alternative approaches to revascularization for patients with three‐vessel or left main coronary artery disease (CAD). Background: Previous studies have demonstrated that, despite higher initial costs, long‐term costs bypass surgery (CABG) in multivessel CAD are similar those percutaneous intervention (PCI). The impact drug‐eluting stents (DES) on these results is unknown. Methods: SYNTAX trial randomized 1,800 either CABG ( n = 897)...
To investigate the feasibility of discrete choice experiments for valuing EQ-5D-5L states using computer-based data collection, consistency estimated regression coefficients produced after modeling preference data, and to examine similarity values derived across countries.Data were collected in Canada, England, The Netherlands, United States (US). Interactive software was developed standardize format tasks countries, except face-to-face interviewing England. task required respondents choose...