A5090887945- Microfluidic and Capillary Electrophoresis Applications
- Rheology and Fluid Dynamics Studies
- Fluid Dynamics and Turbulent Flows
- Microfluidic and Bio-sensing Technologies
- Advancements in Transdermal Drug Delivery
- Fluid Dynamics and Vibration Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Aerodynamics and Acoustics in Jet Flows
- Electrowetting and Microfluidic Technologies
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Heat Transfer and Optimization
- Advanced MEMS and NEMS Technologies
- Analytical Chemistry and Sensors
- Nanofabrication and Lithography Techniques
- Fluid Dynamics and Thin Films
- Neuroscience and Neural Engineering
- Lattice Boltzmann Simulation Studies
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Heat Transfer and Boiling Studies
- Advanced Sensor and Energy Harvesting Materials
- Dermatology and Skin Diseases
- Particle Dynamics in Fluid Flows
- Electrohydrodynamics and Fluid Dynamics
University of California, Berkeley
2012-2023
Stanford University
2018
Rice University
2018
Tata Institute of Fundamental Research
2018
Northeastern University
2018
Harvard University
2018
Cochin University of Science and Technology
2018
University of Oxford
2018
University of California, San Francisco
2000-2017
Berkeley Geochronology Center
2017
The role of streamwise vortex structures in the near-field (x/d < 10) evolution a round jet is examined. In free shear layers vorticity develops into Bernal-Roshko which are pairs. Similar shown to exist jets. These structures, evolve and amplify braid region between primary vortical drastically alter entrainment process near field increase rate at fluid entrained jet. As flow evolves downstream, efficiency entraining increases relative that azimuthal vorticity. Beyond end potential core...
We have demonstrated the fluidic self-assembly of micromachined silicon parts onto and quartz substrates in a preconfigured pattern with submicrometer positioning precision. Self-assembly is accomplished using photolithographically defined part substrate binding sites that are complementary shapes hydrophobic self-assembled monolayers. The patterned passed through film adhesive on water, causing to selectively coat sites. Next, microscopic parts, fabricated from silicon-on-insulator wafers...
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
In recent years, microneedles were proposed as a method to painlessly deliver drugs past the stratum corneum. Microneedles have been fabricated in several designs, but limited studies tested microneedle injections humans. this work, we compare with topical application (TA) investigate if enhance vivo drug delivery corneum.In vitro tests used measure pressures and injection volumes. performed on volar forearm of 11 healthy volunteers. Two sets microneedles, pointed symmetric, develop...
Drug delivery based on MEMS technology requires an invasive interface such as microneedles, which connects the microsystem with biological environment. Two-dimensional arrays of rigid hollow microneedles have been fabricated from single-crystal silicon using a combination deep reactive ion etching and isotropic techniques. The needles are typically 200 /spl mu/m long wide base channel diameter 40 mu/m. fabrication process allows creating either blunt or sharp tips. Their shape size make...
Chronic diseases are becoming more prevalent, and the complexities of managing patients continue to escalate, since their care must be balanced between home clinical settings. Diabetes is most advanced example, where self-monitoring has been shown necessary. Glucometers point-of-care (POC) devices that have become standard platforms at Similarly, many other POC biosensors also developed. Enzymes often used in these sensors because specificity reaction products can electrochemically...
Background The ability to measure blood velocities is critical for studying vascular development, physiology, and pathology. A key challenge quantify a wide range of in vessels deep within living specimens with concurrent diffraction-limited resolution imaging cells. Two-photon laser scanning microscopy (TPLSM) has shown tremendous promise analyzing hundreds micrometers animals cellular resolution. However, current analysis TPLSM-based data limited the lower not adequate study faster many...
A basic step in many biological assays is separating and isolating different types of cells from raw samples. To better meet these requirements microfluidic devices for miniature biomedical analytical systems, an alternative method has been devised by mimicking the physiological process leukocyte recruitment to blood vessel walls: adhesive cell rolling transient tethering. Reproducing interactions on surfaces microstructured fluidic channels can serve capture concentrate even fractionate a...
ABSTRACT There is limited knowledge of interspecies interactions in biofilm communities. In this study, Pseudomonas sp. strain GJ1, a 2-chloroethanol (2-CE)-degrading organism, and putida DMP1, p -cresol-degrading produced distinct biofilms response to model mixed waste streams composed 2-CE various -cresol concentrations. The two organisms maintained commensal relationship, with DMP1 mitigating the inhibitory effects on GJ1. A triple-labeling technique compatible confocal microscopy was...
Noninvasive immunization technologies have the potential to revolutionize global health by providing easy-to-administer vaccines at low cost, enabling mass immunizations during pandemics. Existing such as transdermal microneedles are costly, deliver drugs slowly, and cannot generate mucosal immunity, which is important for optimal immunity against pathogens. We present a needle-free microjet device termed MucoJet, three-dimensional microelectromechanical systems-based drug delivery...
Abstract A research project is currently underway to develop small-scale internal combustion engines fueled by liquid hydrocarbons. The ultimate goal of the MEMS Rotary Internal Combustion Engine Project a hydrocarbon MEMS-size rotary micro-engine capable delivering power on order milli-watts. This part larger effort portable, autonomous generation system with an magnitude improvement in energy density over alkaline or lithium-ion batteries. (Wankel-type) engine well suited for fabrication...
Abstract Design and fabrication of a Silicon-based MEMS rotary engine are discussed in this paper. This work is part an effort currently underway to develop portable, autonomous power generation system potentially capable having order magnitude improvement energy density over alkaline or lithium-ion batteries. Central the development small-scale internal combustion engines fueled by high liquid hydrocarbons delivering on milli-Watts. The (Wankel-type) well suited for due its planar geometry,...
This paper presents a disposable minimally invasive self-calibrating continuous glucose monitor consisting of hollow out-of-plane microneedles to sample interstitial fluid from the epidermis, an integrated porous poly-Si dialysis membrane and enzyme-based flow-through sensor. The proposed system can be fabricated on wafer-level using standard MEMS technology novel in-device enzyme immobilization technique that allows patterning enzymes inside micro-scale flow channels after wafer bonding....
A continuous microfluidic mixer utilizing pulsatile flow micropumps has been created using an SOI process.While individual MEMS mixers, pumps, and valves have developed, this work presents integrated, planar system novel mixing, valving, bonding processes in order to deliver well mixed fluids at controllable rates.