A5103057846- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- CRISPR and Genetic Engineering
- Analytical Chemistry and Sensors
- Graphene and Nanomaterials Applications
- RNA regulation and disease
- Molecular Junctions and Nanostructures
- RNA Interference and Gene Delivery
- Research, Science, and Academia
- Reproductive tract infections research
- Molecular Sensors and Ion Detection
- Career Development and Diversity
- Pharmaceutical and Antibiotic Environmental Impacts
- Pluripotent Stem Cells Research
- Conducting polymers and applications
- Biotin and Related Studies
- Advanced Memory and Neural Computing
- ZnO doping and properties
- Science and Science Education
- Toxin Mechanisms and Immunotoxins
- Nanotechnology research and applications
- Advanced Biosensing Techniques and Applications
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
Keck Graduate Institute
2017-2023
Claremont Colleges
2018-2023
University of California, Berkeley
2014-2021
Cardea Services
2021
University of Copenhagen
2021
Berkeley College
2018
Buck Institute for Research on Aging
2017
Berkeley Geochronology Center
2017
Sensors (United States)
2014-2015
Hearst (United States)
2015
Chronic diseases are becoming more prevalent, and the complexities of managing patients continue to escalate, since their care must be balanced between home clinical settings. Diabetes is most advanced example, where self-monitoring has been shown necessary. Glucometers point-of-care (POC) devices that have become standard platforms at Similarly, many other POC biosensors also developed. Enzymes often used in these sensors because specificity reaction products can electrochemically...
Noninvasive immunization technologies have the potential to revolutionize global health by providing easy-to-administer vaccines at low cost, enabling mass immunizations during pandemics. Existing such as transdermal microneedles are costly, deliver drugs slowly, and cannot generate mucosal immunity, which is important for optimal immunity against pathogens. We present a needle-free microjet device termed MucoJet, three-dimensional microelectromechanical systems-based drug delivery...
Abstract Increasing access to modern clinical practices concomitantly extends lifespan, ironically revealing new classes of degenerative and inflammatory diseases later years. Here, an electronic graphene field‐effect transistor (gFET) is reported, termed EV‐chip, for label‐free, rapid identification quantification exosomes (EV) associated with aging through specific surface markers, CD63 CD151. Studies suggest that blood‐derived carry biomolecules can be used toward diagnostic applications...
Studies of heterochronic parabiosis, where two animals different ages are joined surgically, provided proof-of-principle results that systemic proteins have broad age-specific effects on tissue health and repair. In an effort to identify these proteins, we previously developed a method selectively label the proteome only one animal in parabiosis utilizing bio-orthogonal non-canonical amino acid tagging (BONCAT), which can metabolically during their de novo synthesis by incorporating...
A digital point-of-care biosensor for measuring reactive oxygen species is presented based on novel responsive polymer-based electrodes. The able to detect a drug-induced liver injury by monitoring the oxidative stress in blood.
The discovery of CRISPR has revolutionized the field genome engineering, but potential this technology is far from reaching its limits. In review, we explore broad range applications to highlight rapid expansion beyond gene editing alone. It been demonstrated that can control expression, spatiotemporally image in vivo, and detect specific nucleic acid sequences for diagnostics. addition, new technologies are under development improve quality controls editing, thereby improving reliability...
As we deepen our understanding of biological machineries, increasingly recognize the mechanisms at work within living organisms and vast potential these systems offer for technological innovation. The fusion machineries with cutting-edge technology has to create a new era solutions some most pressing challenges facing humanity today. integration field effect nano biosensing technologies, opens up unprecedented avenues advancements in healthcare, monitoring, biosecurity, much more. Graphene...
State-of-the-art ultra-sensitive blood glucose-monitoring biosensors, based on glucose oxidase (GOx) covalently linked to a single layer graphene (SLG), will be valuable next generation diagnostic tool for personal glycemic level management. We report here our observations of sensor matrix structure obtained using multi-physics approach towards analysis small-angle neutron scattering (SANS) graphene-based biosensor functionalized with GOx under different pH conditions various hierarchical...
A new turn-off fluorescent substrate for horseradish peroxidase is introduced, termed clics, which enhances the sensitivity of commercial enzyme-linked immunosorbant assays (ELISA) by 32-fold and detects chlamydial infections in patients. Clics are cost-effective, stable, can be easily incorporated ELISA kits, therefore should have a great impact fields medicine biology.
Stimuli-responsive polymers have a wide range of clinical applications from targeted drug delivery to medical diagnostics. On page 1433, D. Liepmann, N. Murthy, and co-workers develop new stimuli-responsive polymer that is sensitive reactive oxygen species, utilize it point-of-care biosensor for measuring oxidative stress liver injury.
The discovery of CRISPR technology has revolutionized the fields transcriptional activation and repression, genome editing, gene-based therapeutics, diagnostics. applications this have been rapidly expanding as researchers continue to discover new Cas enzymes, engineer high fidelity orthologs, modify synthesize guide RNAs efficiently direct these enzymes their targets. In talk, we will introduce first-generation DNA biosensors that combine with ultra-sensitivity graphene-based field effect...