A5085010097- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Medicinal Plants and Neuroprotection
- Pregnancy and preeclampsia studies
- ZnO doping and properties
- Viral gastroenteritis research and epidemiology
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- Viral Infections and Immunology Research
- Bioactive Natural Diterpenoids Research
- Vibrio bacteria research studies
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Probiotics and Fermented Foods
- Yersinia bacterium, plague, ectoparasites research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gene expression and cancer classification
- Gastric Cancer Management and Outcomes
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Microbial Metabolism and Applications
Shanghai Customs College
2024
University of Toronto
2024
Hospital for Sick Children
2023
Innovation Team (China)
2022-2023
Shenzhen University
2023
Shenzhen University Health Science Center
2022
Claremont McKenna College
2021
Claremont Colleges
2021
Abstract Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing Tbx15 , thus preventing dilated cardiomyopathy leading to lethal failure. Deletion of Kdm8 mouse cardiomyocytes increased H3K36me2 with activation and repression target genes the NAD + pathway before initiated. supplementation prevented mutant mice, TBX15 overexpression blunted...
Abstract Increasing access to modern clinical practices concomitantly extends lifespan, ironically revealing new classes of degenerative and inflammatory diseases later years. Here, an electronic graphene field‐effect transistor (gFET) is reported, termed EV‐chip, for label‐free, rapid identification quantification exosomes (EV) associated with aging through specific surface markers, CD63 CD151. Studies suggest that blood‐derived carry biomolecules can be used toward diagnostic applications...
Postbiotics possess various functional activities, closely linked to their source bacterial strains and preparation methods. Therefore, the activities of postbiotics need be evaluated through in vitro vivo This study aims prepare a postbiotic explore its antihemolytic, anti-inflammatory, antioxidant, antibacterial activities. Specifically, named PostbioP-6 was prepared by intercepting 1–5 kDa Lacticaseibacillus paracasei Postbiotic-P6 fermentation broth. The results demonstrate that...
The development of novel antibacterial agents from plant sources is emerging as a successful strategy to combat antibiotic resistance in pathogens. In this study, we systemically investigated the activity and underlying mechanisms baicalin against methicillin-resistant
Stably Expressed Genes (SEGs) are a set of genes with invariant expression. Identification SEGs, especially among both healthy and diseased tissues, is clinical relevance to enable more accurate data integration, gene expression comparison biomarker detection. However, it remains unclear how many global SEGs there are, whether development-, tissue- or cell-specific diseases can influence their In this research, we systematically investigate human at single-cell level observe...
Foodborne viruses have become an important threat to food safety and human health. Among the foodborne viruses, group A rotavirus is most pathogen of diarrhea in autumn winter. The field detection crucial for early control infection patient management. Quantitative real-time reverse transcription-polymerase chain reaction widely used virus detection. However, technique relies on high-cost instruments trained personnel, which limit its use In this study, we developed accurate, realizable,...
Abstract Background: Preeclampsia is an important clinical syndrome occurring during pregnancy. It shows genetic disposition, and the risk has large ethnic heterogeneity. The study was designed to investigate of preeclampsia in Chinese pregnancies, apply it early screening disease. Methods: We performed a genome-wide association screen candidate loci associated with people, validated them independent cohort enlarged size. also trained prediction models using genotypes newly identified...
Abstract Gram-negative bacteria deliver effector proteins into eukaryotic host cells through type III and IV secretion systems, causing infections diseases. It remains unclear about the signals guiding specific of effectors. Here, we adopted an in silico approach to analyze mRNA sequences encoding putative peptides essential for effective translocation A surprisingly high proportion effectors showed tolerance on frameshift mutations signal-encoding sequences, contrast, very low percentage...
In article number 2000594, Kiana Aran and co-coworkers show exosomes binding to a graphene field-effect transistor (gFET), termed EV-chip. The EV-chip enables label-free, rapid, point-of-care identification quantification of blood-derived containing biomarkers associated with cancer other age-related diseases. sensor is ideal for use in physician's office or simple biological laboratory. Image credits: Ella Maru Studio.