Mohammed E. Al‐Sofiani

ORCID: 0000-0003-4420-9378
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About
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Research Areas
  • Diabetes Management and Research
  • Diabetes Management and Education
  • Dietary Effects on Health
  • Diabetes Treatment and Management
  • Diabetes and associated disorders
  • COVID-19 Clinical Research Studies
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Artificial Intelligence in Healthcare
  • Mobile Health and mHealth Applications
  • Cardiovascular Health and Risk Factors
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Chronic Disease Management Strategies
  • Medication Adherence and Compliance
  • Diet and metabolism studies
  • Botulinum Toxin and Related Neurological Disorders
  • Adipokines, Inflammation, and Metabolic Diseases
  • Diet, Metabolism, and Disease
  • Long-Term Effects of COVID-19
  • Frailty in Older Adults
  • Pharmacology and Obesity Treatment
  • Clinical practice guidelines implementation
  • Vitamin D Research Studies
  • Sepsis Diagnosis and Treatment
  • Obesity and Health Practices
  • Nutrition and Health in Aging

Johns Hopkins University
2018-2025

King Saud University
2015-2025

King Saud Medical City
2021-2022

Johns Hopkins Medicine
2020

University at Buffalo, State University of New York
2015

David C. Klonoff Jing Wang David Rodbard Michael A. Kohn Chengdong Li and 89 more Dorian Liepmann David Kerr David Ahn Anne L. Peters Guillermo E. Umpierrez Jane Jeffrie Seley Nicole Y. Xu Kevin T. Nguyen Gregg D. Simonson Michael S. D. Agus Mohammed E. Al‐Sofiani Gustavo Armaiz-Peña Timothy S. Bailey Ananda Basu Tadej Battelino Sewagegn Yeshiwas Pierre‐Yves Benhamou B. Wayne Bequette Thomas Blevins Marc D. Breton Jessica R. Castle J. Geoffrey Chase Kong Y. Chen Pratik Choudhary Mark A. Clements Kelly L. Close Curtiss B. Cook Thomas Danne Francis J. Doyle Angela Drincic Kathleen Dungan Steven V. Edelman Niels Ejskjær Juan Espinoza G. Alexander Fleming Gregory P. Forlenza Guido Freckmann Rodolfo J. Galindo Ana María Gómez Hanna A. Gutow Lutz Heinemann Irl B. Hirsch Thanh D. Hoang Roman Hovorka Johan Jendle Linong Ji Shashank Joshi Michaël Joubert Suneil K. Koliwad Rayhan A. Lal M. Cecilia Lansang Wei-An Lee Lalantha Leelarathna Lawrence A. Leiter Marcus Lind Michelle L. Litchman Julia K. Mader Katherine Mahoney Boris Mankovsky Umesh Masharani Nestoras Mathioudakis Alexander Yur'evich Mayorov Jordan Messler Joshua D. Miller Viswanathan Mohan James H. Nichols Kirsten Nørgaard David N. O’Neal Francisco J. Pasquel Athena Philis‐Tsimikas Thomas R. Pieber Moshe Phillip William H. Polonsky Rodica Pop‐Busui Gerry Rayman Eun‐Jung Rhee Steven Russell Viral N. Shah Jennifer L. Sherr Koji Sode Elias K. Spanakis Deborah J. Wake Kayo Waki Amisha Wallia Melissa E. Weinberg Howard Wolpert Eugene E. Wright Mihail Zilbermint Boris Kovatchev

Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...

10.1177/19322968221085273 article EN Journal of Diabetes Science and Technology 2022-03-29

Abstract Background Information on the clinical characteristics and outcomes of hospitalized Covid-19 patients with or without diabetes mellitus (DM) is limited in Arab region. This study aims to fill this gap. Methods In single-center retrospective study, medical records adults confirmed [RT-PCR positive for SARS-CoV2] at King Saud University Medical City (KSUMC)-King Khaled Hospital (KKUH), Riyadh, Saudi Arabia from May July 2020 were analyzed. Clinical, radiological serological...

10.1186/s12933-020-01184-4 article EN cc-by Cardiovascular Diabetology 2020-12-01

Background: The importance of telemedicine in diabetes care became more evident during the coronavirus disease 2019 (COVID-19) pandemic as many people with diabetes, especially those areas without well-established telemedicine, lost access to their health providers (HCPs) this pandemic. Subjects and Methods: We describe a simplified protocol Diabetes Telemedicine Clinic that utilizes technological tools readily available most clinics around world. report satisfaction 145 patients 14 HCPs who...

10.1177/1932296820947094 article EN cc-by Journal of Diabetes Science and Technology 2020-08-07

As the world continues to cautiously navigate its way through coronavirus disease 2019 (COVID-19) pandemic, several breakthroughs in therapies and vaccines are currently being developed scrutinized. Consequently, alternative for severe acute respiratory 2 (SARS-CoV-2) prevention, such as vitamin D supplementation, while hypothetically promising, require substantial evidence from countries affected by COVID-19. The present retrospective case–control study aims identify differences status...

10.1007/s40520-021-01831-0 article EN other-oa Aging Clinical and Experimental Research 2021-03-31
David C. Klonoff Guido Freckmann Stefan Pleus Boris Kovatchev David Kerr and 89 more Chui Tse Chengdong Li Michael S. D. Agus Kathleen Dungan Barbora Voglová Hagerf Jan S. Krouwer Wei-An Lee Shivani Misra Sang Youl Rhee Ashutosh Sabharwal Jane Jeffrie Seley Viral N. Shah Nam K. Tran Kayo Waki Chris Worth Tiffany Tian Rachel E. Aaron Keetan Rutledge Cindy Ho Alessandra T. Ayers Amanda Adler David Ahn Halis Kaan Aktürk Mohammed E. Al‐Sofiani Timothy S. Bailey Matt Baker Lia Bally Raveendhara R. Bannuru Elizabeth M Bauer Yong Mong Bee Julia E. Blanchette Eda Cengiz J. Geoffrey Chase Kong Y. Chen Daniel R. Cherñavvsky Mark A. Clements Gerard L. Coté Ketan Dhatariya Andjela Drincic Niels Ejskjær Juan Espinoza Chiara Fabris G. Alexander Fleming Mônica Andrade Lima Gabbay Rodolfo J. Galindo Ana María Gómez Medina Lutz Heinemann Norbert Hermanns Thanh D. Hoang Sufyan Hussain Peter G. Jacobs Johan Jendle Shashank Joshi Suneil K. Koliwad Rayhan A. Lal Lawrence A. Leiter Marcus Lind Julia K. Mader Alberto Maran Umesh Masharani Nestoras Mathioudakis Michael J. McShane Chhavi Mehta Sun Joon Moon James H. Nichols David N. O’Neal Francisco J. Pasquel Anne L. Peters Andreas Pfützner Rodica Pop‐Busui Pratistha Ranjitkar Connie M. Rhee David B. Sacks Signe Schmidt Simon M. Schwaighofer Bin Sheng Gregg D. Simonson Koji Sode Elias K. Spanakis Nicole L. Spartano Guillermo E. Umpierrez Maryam Vareth Hubert W. Vesper Jing Wang Eugene E. Wright Alan H.B. Wu Sewagegn Yeshiwas Mihail Zilbermint Michael A. Kohn

An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).

10.1177/19322968241275701 article EN Journal of Diabetes Science and Technology 2024-10-06

OBJECTIVE To compare the fasting experience and glycemic control during Ramadan among people with type 1 diabetes (PWT1D) who use automated insulin delivery (AID) versus other modalities of treatment. RESEARCH DESIGN AND METHODS A total 294 PWT1D attempted in 2022 were categorized on basis treatment modality into one five groups: 1) AID (n = 62); 2) conventional pump + continuous glucose monitoring (CGM; n 37); 3) self-monitoring blood (SMBG; 8); 4) multiple daily injections (MDI) CGM 155);...

10.2337/dc23-1968 article EN Diabetes Care 2024-01-30

Background: Diabetes mellitus (DM) and vitamin D deficiency are major health concerns around the world. Evidence suggests a possible role of in improvement insulin secretion sensitivity. Objectives: We assessed whether supplementation could be used deficient-type II diabetes to improve glucose metabolism, components metabolic syndrome (MetS) specific inflammatory biomarkers. Patients Methods: A double blind, randomized clinical trial was conducted King Khalid University Hospital, Saudi...

10.5812/ijem.22604 article EN cc-by-nc International Journal of Endocrinology and Metabolism 2015-01-10

To minimize the spread of Coronavirus Disease-2019, Saudi Arabia imposed a nationwide lockdown for over 6 weeks. We examined impact on glycemic control in individuals with type 1 diabetes (T1D) using continuous glucose monitoring (CGM); and assessed whether changes differ between those who attended telemedicine visit during versus did not.Flash CGM data from 101 T1D were retrospectively evaluated. Participants categorized into two groups: Attended (n = 61) or not attend 40). Changes metrics...

10.1016/j.diabres.2021.108682 article EN other-oa Diabetes Research and Clinical Practice 2021-02-03

Diabetes treatment requires the use of medical sharps for glycemic control. Improper collection and disposal poses substantial threats to people with diabetes (PWD), health care professionals, environment, public health. To identify prevalence predictors improper practices among PWD in Saudi Arabia. We surveyed 288 at King Saud University Center Riyadh, Arabia, from September October 2021. asked questions about demographics, history, practices, prior education on proper practices. defined...

10.1177/19322968251318747 article EN Journal of Diabetes Science and Technology 2025-02-14

Abstract Aims To determine the prevalence and factors associated with depression anxiety among people without diabetes during coronavirus disease 2019 (COVID‐19) outbreak. Methods A cross‐sectional questionnaire‐based study collecting demographic mental health data from 2166 participants living in Arab Gulf region (568 diabetes, 1598 diabetes). Depression were assessed using 9‐item Patient Health Questionnaire 7‐item Generalized Anxiety Disorder scale, respectively. Results The of symptoms...

10.1111/1753-0407.13149 article EN Journal of Diabetes 2020-12-23

<h3>Importance</h3> The net benefit of aspirin for prevention cardiovascular disease (CVD), particularly primary prevention, remains debated in people with and without diabetes. Recent studies suggest that the benefits preventive may be outweighed by potential harm older adults; therefore, it is important to monitor current use order minimize risk future oldest segment population. <h3>Objective</h3> To determine prevalence US adults diabetes both secondary age, sex, CVD category. <h3>Design,...

10.1001/jamanetworkopen.2021.12210 article EN cc-by-nc-nd JAMA Network Open 2021-06-21

Abstract Aim To report on the effectiveness and safety of MiniMed 780G automated insulin delivery system in real‐world users during month Ramadan. Materials Methods CareLink Personal data were extracted from Gulf region. Users included if they had ≥10 days sensor glucose Ramadan 2022 as well before after. For main analysis, continuous monitoring endpoints aggregated per reported by time day (daytime: 05.31‐18.00 h, night‐time). Additional analyses performed to study pace at which algorithm...

10.1111/dom.15389 article EN cc-by-nc-nd Diabetes Obesity and Metabolism 2023-12-27

Previous studies have suggested less cardioprotective benefit of aspirin in adults with diabetes, raising concerns about "aspirin resistance" and potentially reduced effectiveness for prevention cardiovascular disease (CVD). To examine differences platelet response to by diabetes status. We examined before after (81 mg/day 14 days) 2113 (175 1,938 without diabetes), the Genetic Study Aspirin Responsiveness cohort, who had family history early-onset CVD. In vivo activation (urinary...

10.1210/jc.2018-01254 article EN The Journal of Clinical Endocrinology & Metabolism 2018-09-27

Abstract Context Older adults have the greatest burden of diabetes; however, contribution age-related muscle loss to its development remains unclear. Objective We assessed relationship lean body mass with aging incident diabetes in community-dwelling adults. Design and Setting studied participants Baltimore Longitudinal Study Aging median follow-up 7 years (range 1-16). Cox proportional hazard models age as time scale were used. Time-dependent measures updated at each visit available....

10.1210/jendso/bvaa043 article EN cc-by-nc-nd Journal of the Endocrine Society 2020-04-30

ObjectiveWell-controlled glucose levels (ie, 70-180 mg/dL) have been associated with lower mortality from COVID-19. The addition of dexamethasone to COVID-19 treatment protocols has raised concerns about the potential negative consequences dexamethasone-induced hyperglycemia.MethodsWe developed a protocol guide management hyperglycemia in hospitalized patients Two 4 medical teams managing at tertiary center Saudi Arabia used and other 2 continued manage discretion treating physicians...

10.1016/j.eprac.2021.07.016 article EN other-oa Endocrine Practice 2021-08-03

&lt;p dir="ltr"&gt;Objective: To compare the fasting experience and glycemic control during Ramadan among people with type 1 diabetes (PWT1D) who use automated insulin delivery (AID) versus other modalities of treatment. Research Design Methods: A total 294 PWT1D attempted 2022 were categorized based on treatment modality into: 1) AID (n=62); 2) Conventional pump + CGM (n=37); 3) Pump self-monitoring blood glucose (SMBG)(n=8); 4) Multiple daily injections (MDI) (n=155); 5) MDI SMBG (n=32)....

10.2337/figshare.24938940.v1 preprint EN cc-by-nc-sa 2024-01-30

Background: Poor adherence to lipid-lowering drugs in diabetic patients with dyslipidemia increases has been linked an increased cardiovascular risk. A better understanding of the determinants and treatment satisfaction among people diabetes is crucial. Objective: We aimed assess prevalence drugs, identify its determinant factors, evaluate users who have dyslipidemia. Methods: surveyed 398 adult dyslipidemia, using a validated medication survey (Adherence Refills Medications Scale)...

10.1177/10600280241262513 article EN Annals of Pharmacotherapy 2024-07-25

Abstract Aim To evaluate the efficacy of a fixed‐ratio combination insulin glargine 100 U/mL plus lixisenatide (iGlarLixi) in people with type 2 diabetes (T2D) using derived time‐in‐range (dTIR). Methods Participant‐level data from LixiLan‐L, LixiLan‐O and LixiLan‐G were pooled dTIR (70‐180 mg/dL), time‐above‐range (&gt; 180 mg/dL) time‐below‐range (dTBR; &lt; 70 calculated participant seven‐point self‐monitored blood glucose profiles. Results This analysis included 2420 participants...

10.1111/dom.15811 article EN cc-by-nc Diabetes Obesity and Metabolism 2024-09-08

Rare disease Background:Diplopia is a common subjective complaint that can be the first manifestation of serious pathology.Here, we report rare case midbrain infarction involving lateral subnucleus oculomotor nuclear complex presenting as diplopia, with no other stroke manifestations. Case Report:An 83-year-old right-handed white man past medical history diabetes mellitus, hypertension, dyslipidemia, and coronary artery presented to emergency department (ED) diplopia unsteadiness.Two days...

10.12659/ajcr.893875 article EN American Journal of Case Reports 2015-01-01

We examined the hearing function in adults with and without type 1 diabetes (T1D) to investigate whether an association exists between loss duration of diabetes, haemoglobin A1C level, complications levels select serum urinary biomarkers.We measured pure tone audiometry (PTA) thresholds; C-reactive protein (CRP), vascular endothelial growth factor (VEGF), soluble receptors for advanced glycation end-product (sRAGE); isoprostane 30 T1D (age 43.8 ± 11.4 years). also PTA thresholds 11 53 5.5...

10.1002/dmrr.3312 article EN Diabetes/Metabolism Research and Reviews 2020-03-19
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