Brian G. Kral
A5017395254- Genetic Associations and Epidemiology
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Asthma and respiratory diseases
- RNA modifications and cancer
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and disorders
- Cardiovascular and exercise physiology
- Inflammatory Biomarkers in Disease Prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
University of Colorado Anschutz Medical Campus
2022
Broad Institute
2020
Brigham and Women's Hospital
2020
Circadian (United States)
2020
National Heart Lung and Blood Institute
2016
National Center for Advancing Translational Sciences
2016
University of Baltimore
2015
Cedars-Sinai Medical Center
2013-2014
OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, high blood pressure, with an increased risk type 2 diabetes cardiovascular disease. This study tests whether common genetic variants pleiotropic effects account for some the correlated architecture among five phenotypes that define MetS. RESEARCH DESIGN AND METHODS Seven studies STAMPEED consortium, comprising 22,161 participants European ancestry, underwent...
Background Genome‐wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite variant‐based genome‐wide improving our understanding of the genetics CAD, contribution structural (SVs) to risk CAD remains largely unclear. Method and Results We leveraged SVs detected from high‐coverage whole genome sequencing data in a diverse group participants National Heart Lung Blood Institute's Trans‐Omics Precision Medicine...
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery lipid-associated alleles using whole genome sequencing (WGS), partly due to limited sample sizes, ancestral diversity, interpretation clinical significance. Among 66,329 ancestrally diverse (56% non-European) participants, we associate 428M variants from deep-coverage WGS with lipid levels; ~400M were not...
Background— Although age and sex distributions of calcified coronary plaque have been well described in the general population, noncalcified (NCP) remain unknown. This is important because NCP a putative precursor for clinical artery disease could serve as sentinel aggressive primary prevention, especially high-risk populations. We examined healthy 30- to 74-year-old individuals from families with early onset disease. Methods Results— Participants GeneSTAR family study (N=805), mean...
<b><i>Background:</i></b> African Americans (AAs) have a higher prevalence of extreme ischemic white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) than do European (EAs) based the Cardiovascular Health Study (CHS) score. Ischemic disease, limited to deep matter, may be biologically distinct from disease in other regions and reflect previously observed trend toward an increased risk subcortical lacunar infarcts AAs. We hypothesized that WMH volume...
Abstract BACKGROUND The blood brain barrier (BBB) severely limits delivery of therapeutic agents to the brain. Regadenoson, an FDA approved adenosine A2 agonist, transiently increases BBB permeability in rodents a 70kDa dextran. This multi-institutional, NIH funded study examined regadenoson’s ability alter patients with gliomas. METHODS Adults supratentorial gliomas at low-risk for regadenoson complications were treated one seven dose levels known be safe humans. Successful disruption was...
Abstract Background Previous work has shown a role of CCL2, key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor provides protection against human atherosclerotic cardiovascular disease. Methods Computationally predicted damaging or loss-of-function (REVEL > 0.5) variants within CCR2 were detected whole-exome-sequencing data from 454,775 UK Biobank participants and tested for association with endpoints...
Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant factor for microstructural disruption apparently healthy middle-aged individuals a family history of early-onset coronary artery disease.This was cross-sectional analysis participants Genetic Study Atherosclerosis Risk DTI. Regional fractional anisotropy 181 segmented...
<h3>Background</h3> Siblings of individuals with premature coronary heart disease have a high prevalence low-density lipoprotein cholesterol (LDL-C) levels requiring treatment. <h3>Objective</h3> To evaluate management strategies for LDL-C in apparently healthy 30- to 59-year-old siblings documented prior age 60 years. <h3>Methods</h3> In 2-year trial care provided by either nurse trained lipid (NURS) or enhanced primary (EPC), which physicians received recommendations based on national...
Previous studies have suggested less cardioprotective benefit of aspirin in adults with diabetes, raising concerns about "aspirin resistance" and potentially reduced effectiveness for prevention cardiovascular disease (CVD). To examine differences platelet response to by diabetes status. We examined before after (81 mg/day 14 days) 2113 (175 1,938 without diabetes), the Genetic Study Aspirin Responsiveness cohort, who had family history early-onset CVD. In vivo activation (urinary...
We aim to determine, in healthy high-risk adults, the association between subclinical coronary artery disease and white matter hyperintensity (WMH) volume location, independent of atherosclerotic risk factors.Seven hundred eighty-two asymptomatic first-degree relatives index cases with early-onset (<60 years old) from GeneSTAR (Genetic Study Atherosclerosis Risk) contemporaneous computed tomography angiography brain magnetic resonance imaging were analyzed. Multilevel mixed-effects linear...