A5102925331- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Extracellular vesicles in disease
- Amino Acid Enzymes and Metabolism
- Meningioma and schwannoma management
- Down syndrome and intellectual disability research
- Dementia and Cognitive Impairment Research
- interferon and immune responses
- Chronic Disease Management Strategies
- Sarcoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Heart Failure Treatment and Management
- Brain Metastases and Treatment
- Neurogenetic and Muscular Disorders Research
- Neuroendocrine Tumor Research Advances
- Hematological disorders and diagnostics
- Retinal Imaging and Analysis
- Peripheral Neuropathies and Disorders
- Global Public Health Policies and Epidemiology
- Prion Diseases and Protein Misfolding
- IgG4-Related and Inflammatory Diseases
University of Colorado System
2024-2025
University of Colorado Anschutz Medical Campus
2023-2024
University of Colorado Health
2024
University of Southern California
2020-2023
University of Colorado Denver
2023
Instituto Tecnológico de Santo Domingo
2020-2021
Children's Hospital of Los Angeles
2021
Keck Hospital of USC
2021
Cedars-Sinai Medical Center
2018-2019
Abstract During the diagnostic workup of lung adenocarcinomas (LAC), pathologists evaluate distinct histological tumor growth patterns. The percentage each pattern on multiple slides bears prognostic significance. To assist with quantification patterns, we constructed a pipeline equipped convolutional neural network (CNN) and soft-voting as decision function to recognize solid, micropapillary, acinar, cribriform non-tumor areas. Slides primary LAC were obtained from Cedars-Sinai Medical...
Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first decades life locus coeruleus (LC), brain's main noradrenaline supply. However, technical challenges in-vivo assessments have impeded research into role LC disease. We studied participants with or known to be at-risk for mutations genes causing autosomal-dominant disease (ADAD) early onset, providing a unique window pathogenesis largely disentangled from age-related factors. Using high-resolution MRI...
Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals DS are often excluded. Furthermore, timely diagnosis management is not available. Of the genetic causes people represent largest cohort. Currently, there knowledge gap regarding underlying neurobiological mechanisms DS-related AD...
Abstract The Grade of meningioma has significant implications for selecting treatment regimens ranging from observation to surgical resection with adjuvant radiation. For most patients, meningiomas are diagnosed radiologically, and is not determined unless a procedure performed. goal this study train novel auto-classification network determine I II using T1-contrast enhancing (T1-CE) T2-Fluid attenuated inversion recovery (FLAIR) magnetic resonance (MR) images. Ninety-six consecutive naïve...
Abstract Abnormally phosphorylated tau, an indicator of Alzheimer’s disease, accumulates in the first decades life locus coeruleus (LC), brain’s main noradrenaline supply. However, technical challenges reliable in-vivo assessments have impeded research into role LC disease. We studied participants with or known to be at-risk for mutations genes causing autosomal-dominant disease (ADAD) early onset, providing a unique window pathogenesis largely disentangled from age-related factors. Using...
Abstract The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, an increased mortality risk for people Alzheimer’s disease (AD) and/or Down syndrome (DS). However, few studies have evaluated the neuropathological inflammatory sequelae postmortem brain tissue obtained from AD DS severe infections. We examined tau, beta-amyloid (Aβ), markers nucleoprotein DS, AD, healthy non-demented controls compared non-infected each...
Pulmonary capillary hemangiomatosis (PCH) is a rare and controversial entity that known to be cause of pulmonary hypertension microscopically characterized by proliferation dilated capillary-sized channels along in the alveolar walls. Clinically, it mostly seen adults. Clinical features are nonspecific findings such as shortness breath, cough, chest pain, fatigue. It can clinically indistinguishable from pre-capillary arterial disorders primary (PAH) or chronic thromboembolic hypertension....
We describe a patient with cerebral amyloid angiopathy-related inflammation (CAA-ri) presenting as Alzheimer disease (AD) mass lesion symptom onset at age 59. He was found to have nonenhancing in the right temporal lobe on magnetic resonance imaging without evidence of hemorrhage. underwent biopsy which showed beta blood vessel walls and perivascular inflammatory infiltrate consistent CAA-ri. Neurofibrillary tangles were present flortaucipir positron emission tomography bilateral signal...
To describe a case of paraneoplastic neuronal intermediate filament (NIF) encephalitis associated with chronic lymphocytic leukemia (CLL), highlighting postmortem neuropathological findings.
Background: Down syndrome (DS) is one of the most commonly occurring chromosomal conditions. Most individuals with DS develop Alzheimer’s disease (AD) by 50 years age. Recent evidence suggests that AD pathology in locus coeruleus (LC) an early event sporadic AD. It likely widespread axonal network LC neurons contributes to spread tau brain, although this has not been investigated DS-AD. Objective: The main purpose study was profile and neuroinflammation LC, comparing DS-AD postmortem human...
ABSTRACT Chordomas are rare, generally slow-growing spinal tumors that nonetheless exhibit progressive characteristics over time, leading to malignant phenotypes and high recurrence rates, despite maximal therapeutic interventions. The notoriously resistant therapies often in locations make gross total resections difficult. Here, we describe a new chordoma cell line (ARF-8) derived from an extensive clival extended back the cervical spine. From cultured characterized ARF-8 cellular...
Chordomas are rare, generally slow-growing spinal tumors that nonetheless exhibit progressive characteristics over time, leading to malignant phenotypes and high recurrence rates, despite maximal therapeutic interventions. The notoriously resistant therapies often located in regions complicate achieving gross total resections. Cell lines from these rare as well. We cultured a new chordoma cell line (ARF-8) derived an extensive clival extended back the cervical spine. characterized ARF-8...
Parkinson's disease (PD) is a severe neurological for which there no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces sural nerve tissue into either the basal forebrain containing nucleus basalis Meynert (NBM) midbrain substantia nigra (SN). The grafts did not exhibit significant cell death host-tissue reaction up to 55 months post-grafting contained peripheral...
Meningiomas are the most common primary brain tumors in adults with management varying widely based on World Health Organization (WHO) grade. However, there limited datasets available for researchers to develop and validate radiomic models. The purpose of our manuscript is report first dataset meningiomas Cancer Imaging Archive (TCIA).
Abstract Diffuse midline glioma, H3 K27M-altered, WHO grade 4 is an infiltrating glioma; however, K27M mutation can also be seen in circumscribed, non-infiltrating gliomas and rarely non-midline tumors. We report 2 unusual examples. A 37-year-old female developed a right posterior frontal resection showed infiltrative tumor with brisk mitotic activity, elevated MIB-1 (20%), negative p53 expression, ATRX retention, but no necrosis or microvascular proliferation. Molecular workup neither...
Abstract BACKGROUND Banan et al (PMID 2776277) recently identified infratentorial IDH-mutant astrocytomas (Inf-IDHmt) as a distinct subtype in which 80% have non-canonical mutations, precluding the use of IDH1 R132H immunohistochemistry (IHC) for diagnosis. They note “molecular testing is critical detection these tumors”. Only 47% ATRX loss by IHC and only 56% MGMT promotor methylation. Thus, it that neurosurgeons take this into account during surgical planning due to requirement adequate...
Abstract Background The neuropathology associated with PSEN1 mutations shares many features late‐onset Alzheimer’s disease although atypical are also seen. An important question is whether the manifestations of dose‐dependent. We present neuropathological findings a homozygote for pathogenic A431E mutation in relative to heterozygotes and finding retinal Aβ lesions consistent those that were topographically detected vivo by fluorescence imaging. Methods A began having symptoms at age 33...
Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) and sporadic late‐onset AD (LOAD) have similar biomarker profiles, supporting a shared pathophysiology. While both ADAD LOAD are known to be heterogeneous, there few studies that compared the heterogeneity of neurodegeneration as indexed by volumetric MRI in ADAD. Here we apply data‐driven model brain atrophy subtypes from characterize within Method We used cross‐sectional ADNI Estudio de la Enfermaded Alzheimer en...
Introduction: There is sparse published data on Heart Failure (HF) in the Caribbean region where cultural, ethnic and socioeconomical differences may play a role all aspects of this entity. We sought to study clinical profiles treatment characteristics patients with HF Dominican Republic. Methods: Electronic records tertiary care CV center were used recruit stable from outpatient cardiology clinic immediately post hospital discharge. Results: From May 2015 2020, 700 consecutive subjects any...