A5016907861- Autoimmune Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Protease and Inhibitor Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- S100 Proteins and Annexins
- Amyotrophic Lateral Sclerosis Research
- Cellular transport and secretion
- Plant Virus Research Studies
- Neurological disorders and treatments
- Cerebrovascular and genetic disorders
- Alzheimer's disease research and treatments
- Parvovirus B19 Infection Studies
- Obsessive-Compulsive Spectrum Disorders
- Gastrointestinal disorders and treatments
- Blood groups and transfusion
- Herpesvirus Infections and Treatments
- Esophageal and GI Pathology
- Acute Lymphoblastic Leukemia research
- Biotin and Related Studies
- Neurogenetic and Muscular Disorders Research
- Peroxisome Proliferator-Activated Receptors
University of Colorado Anschutz Medical Campus
2020-2024
Mayo Clinic
2011-2024
WinnMed
2007-2024
University of Colorado Denver
2020-2024
University at Buffalo, State University of New York
2024
University of Colorado System
2024
Kiyatec (United States)
2024
Neurology, Inc
2022
Florida College
2010-2020
University of Florida
2010-2020
Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease and other tauopathies, but recent studies in conditional mouse model tauopathy (rTg4510) have suggested that NFT formation can be dissociated from memory loss neurodegeneration. This suggests NFTs not the major neurotoxic tau species, at least during early stages pathogenesis. To identify protein we performed biochemical analyses on brain tissues rTg4510 then correlated levels these proteins with loss. We...
Abstract Neuronal and glial deposition of misfolded, proteolytically processed, polyubiquitinated abnormally phosphorylated C‐terminal fragments (CTFs) the TAR DNA binding protein‐43 (TDP‐43) is a pathological hallmark frontotemporal lobar degeneration with ubiquitin positive inclusions (FTLD‐U) certain cases amyotrophic lateral sclerosis. We demonstrate that TDP‐43 can be processed by caspases upon induction apoptosis to major 35 kDa minor 25 CTF. These are initially soluble, but over time...
Numerous loss-of-function mutations in the progranulin ( GRN ) gene cause frontotemporal lobar degeneration with ubiquitin and TAR–DNA binding protein 43-positive inclusions by reduced production secretion of GRN. Consistent observation that has neurotrophic properties, pharmacological stimulation is a promising approach to rescue haploinsufficiency prevent disease progression. We therefore searched for compounds capable selectively increasing levels. Here, we demonstrate four independent...
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in females and gynecologic death. Despite identification a number serum biomarkers, methods to identify early-stage disease predict prognosis remain scarce. We have evaluated two biologically connected leukocyte protease inhibitor (SLPI) progranulin (PGRN).Two-hundred frozen plasma samples were acquired from Mayo Clinic Biospecimen Repository for Ovarian Cancer Research. Samples obtained 50 patients with...
Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications patients with concurrent systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS). Given agents can increase all hematopoietic cell lineages, it is unclear if an increased risk exacerbation underlying lymphocyte-driven autoimmune...
To report a case of JC virus granule cell neuronopathy (GCN) mimicking paraneoplastic cerebellar degeneration (PCD).
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder of which approximately 300 cases have been reported in the literature. Patients with RTS often present early life skeletal and dental abnormalities, short stature, juvenile cataracts, characteristic poikilodermal rash. They are at increased risk for development osteosarcoma that usually presents by second decade life. The genetic defects underlying truncating mutations RECQL4, gene involved chromosomal stability. Several...
Instruction in hematopathology at Mayo Medical School has evolved from instructor‐guided direct inspection under the light microscope (laboratory method), to photomicrographs of glass slides with classroom projection (projection method). These methods have not been compared directly date. Forty‐one second‐year medical students participated this pilot study, a prospective, randomized, crossover study measuring educational performance during hematology pathophysiology course. The were...
Rothmund-Thomson syndrome (RTS) is an autosomal recessive disorder caused by biallelic mutations in RECQL4, a helicase involved with chromosomal instability and DNA repair. Patients typically present poikilodermatous facial rash, photosensitivity, congenital bony abnormalities, short stature, have predilection for osteosarcoma cutaneous malignancies. We 34-year-old male RTS patient, previously diagnosed of the right forearm which was successfully treated resection chemotherapy, who has had...
A 32-year-old man presented with hearing loss and gait difficulties. His symptoms, including double vision, dysarthria, dysphagia, neck posturing, tremors, evolved rapidly over 9 months. Within 15 months of onset, he used a wheelchair. He experienced no improvement after trials intravenous methylprednisolone, immunoglobulins, plasmapheresis, rituximab. CSF testing was unrevealing except for elevated proteins oligoclonal bands. underwent serial brain imaging (figure). Extensive laboratory...
To prospectively assess anti-JCV antibody index (AI) and its relationship to immunoglobulin levels in ocrelizumab-treated MS patients.Monocentric prospective observational study over 24 months assessing AI patients before after initiation of ocrelizumab.No significant change titers was observed 458 ± 300 days ocrelizumab (n = 45, 0.7 2.21 vs. 0.6 2.06, p 0.8). Seroconversion occurred 1/20 initially seronegative patients. There no correlation between changes immunoglobulins.Treatment with is...
Background and objectives: The literature on severe West Nile virus (WNV) neuroinvasive disease (WNND) in patients treated with anti-CD20 therapies is limited to case reports. We systematically characterize cases of WNND the tertiary academic UCHealth system. Methods: A retrospective cohort (January 2016 January 2024) a validated diagnosis medication use was identified electronic medical record (EMR) query followed by individual chart review. Results: 25 patients, whom multiple sclerosis...
Abstract Objective To define the epidemiology and clinical presentation of seropositive neuromyelitis optica spectrum disorder (NMOSD) in a large US health system. Methods We completed retrospective observational study adult patients University Colorado Health System from 1 January 2011 to 31 December 2020, using Data Compass (HDC), data warehouse that combines electronic information with claims public Colorado. screened HDC for either (1) an abnormal aquaporin‐4 IgG test or (2) any G36...
Abstract Drug discovery is a reductive process in which druglike entities are carried through increasingly complex assay formats to tease out the compounds best suited for human studies. In vivo efficacy remains benchmark successful preclinical drug development. Cell-based models mainstay early stages but translatability of different across platforms challenge. oncology, patient-derived xenografts (PDX) gold standard animal studies because they recapitulate key features tumors including...