Steven L. Carroll
A5071472484- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Genetic Associations and Epidemiology
- Neuropeptides and Animal Physiology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Soft tissue tumors and treatment
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Hereditary Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Soft tissue tumor case studies
- Signaling Pathways in Disease
Medical University of South Carolina
2015-2024
MUSC Hollings Cancer Center
2023-2024
University of Alabama at Birmingham
2008-2021
Boston University
2017-2018
University of Miami
2017-2018
Framingham Heart Study
2018
Institute for Neurodegenerative Disorders
2018
The University of Texas Health Science Center at San Antonio
2018
Erasmus MC
2018
Johns Hopkins University
2016-2018
Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP) and corticobasal syndrome, a common extended haplotype spanning across MAPT locus is associated with increased risk of PSP Parkinson's disease.We identified rare variant (p.A152T) patient clinical diagnosis assessed its frequency multiple independent series patients neurodegenerative conditions...
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated AD. Recently, several rare variants identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin C (UNC5C) that affect risk for Despite the many successes, architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance...
Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture AD among other populations is less understood.We conducted a transethnic genome-wide association study (GWAS) late-onset Stage 1 sample including Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by Disease Genetics Consortium. Suggestive results from novel were followed up using summarized International Genomics Project GWAS dataset.Genome-wide...
Schwann cell dedifferentiation and proliferation is a prerequisite to axonal regeneration in the injured peripheral nervous system. The neuregulin (NRG) family of growth differentiation factors may play particularly important role this process, because these axon-associated molecules are potent mitogens vitro. We have examined DNA synthesis expression NRGs their receptors, erbB membrane tyrosine kinases, rat sciatic nerve, sensory ganglia, spinal cord 0-30 d postaxotomy. Analysis NRG cDNAs...
All members of the neurotrophin family neuronal growth factors promote survival and neurite outgrowth dorsal root ganglion (DRG) neurons in vitro. The trk protooncogenes encodes receptors that are now thought to mediate biological effects neurotrophins. In order learn more about dependence DRG on neurotrophins vivo, we have studied mRNA expression developing DRGs embryonic postnatal rats. We show here expressed thoracic lumbar by day 13 (E13), which is only 24-48 hr after neurogenesis begins...
Abstract Introduction Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD would be valuable, as non‐AD intellectual disabilities DS overlap clinically. We hypothesized that elevations amyloid β (Aβ) peptides phosphorylated‐tau neuronal exosomes may document preclinical AD. Methods neuropathogenic proteins Aβ 1–42 , P‐T181‐tau, P‐S396‐tau were quantified by enzyme‐linked immunosorbent assays extracts purified...
To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF).NF1 experts from various research clinical backgrounds reviewed terms currently in use for cNF as well clinical, histologic, radiographic features these tumors using published unpublished data.Neurofibromas develop within nerves, soft tissue, skin. The primary distinction between other is that are limited to skin whereas may involve skin, but not There important cellular,...
<h3>Objective:</h3> To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) the <i>ATP-binding cassette, subfamily A</i> (<i>ABC1</i>), <i>member 7</i> (<i>ABCA7</i>) gene, known risk factor for late-onset AD. <h3>Methods:</h3> Custom capture sequencing was performed on ∼150 kb encompassing <i>ABCA7</i> 40 AA cases and 37 controls carrying allele (rs115550680). Association testing an deletion identified large data sets (discovery n = 1,068;...
Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals DS are often excluded. Furthermore, timely diagnosis management is not available. Of the genetic causes people represent largest cohort. Currently, there knowledge gap regarding underlying neurobiological mechanisms DS-related AD...
Abstract The neuregulin (NRG) family of growth and differentiation factors their erbB receptors contribute importantly to the development nervous system, but distribution function in adult brain are poorly understood. present study showed that erbB2, erbB3, erbB4 transcripts protein distributed throughout all areas rat brain. These three were differentially expressed neurons glia. Some only a subset kinases, whereas other sequestered each these polypeptides into distinct cellular...
Neuregulin-1 (NRG-1) regulates developmental neuronal survival and synaptogenesis, astrocytic differentiation, microglial activation. Given these NRG-1 actions, we hypothesized that the synaptic loss, gliosis, inflammation, death occurring in Alzheimer disease (AD) is associated with altered expression of its receptors (the erbB2, erbB3, erbB4 membrane tyrosine kinases). We examined distribution erbB kinases hippocampus AD patients cognitively normal controls transgenic mice coexpress...
Herpes simplex virus type 1 (HSV-1) mutants lacking the γ134.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 to express immunostimulatory genes may potentiate therapeutic efficacy. We have previously demonstrated improved preclinical efficacy, biodistribution, and safety of M002, a γ134.5-deleted engineered murine IL-12. Herein, we describe biodistribution M032, that expresses human IL-12 after intracerebral administration nonhuman primates,...
Neuroinflammation is a key element of AD pathology and conceivably result disturbed resolution. Resolution inflammation an active process which strictly orchestrated following the acute inflammatory response after removal stimuli. Acute actively terminated by specialized pro-resolving mediators (SPMs) thereby promoting healing return to homeostasis. Failed resolution may contribute persistent neuroinflammation aggravate pathology. BLT1 (leukotriene B4 receptor) ChemR23 (chemerin receptor 23)...
Abstract The exact mechanisms leading to CNS inflammation and myelin destruction in multiple sclerosis its animal model, experimental allergic encephalomyelitis (EAE) remain equivocal. In both EAE, complement activation is thought play a pivotal role by recruiting inflammatory cells, increasing phagocytosis macrophages, exerting direct cytotoxic effects through the deposition of membrane attack complex on oligodendrocytes. Despite this assumption, attempts evaluate complement’s contribution...
Surface-active phospholipid-containing particles are traditionally considered to be the product of type II pneumocytes. We now demonstrate membrane-bound lamellar cytoplasmic organelles in adult and suckling rat enterocytes that densely reactive with phospholipid-staining reagents. These structures were seen basolateral space, within intercellular junctions, unraveling on lumenal surface, more abundant after fat feeding. Light scrapings intestinal mucosa washings contained these bodies, as...
Tamoxifen is widely used to treat estrogen receptor-positive breast cancer. Recent findings that tamoxifen and its derivative 4-hydroxytamoxifen (OHT) can exert receptor-independent cytotoxic effects have prompted the initiation of clinical trials evaluate use in receptor-negative malignancies. For example, OHT malignant peripheral nerve sheath tumors (MPNST) where not involved. In this study, we gained insights into by studying how it kills MPNST cells. Although caspases were activated...