Ryan Huebinger
A5070206207- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Alzheimer's disease research and treatments
- Disaster Response and Management
- Airway Management and Intubation Techniques
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Sepsis Diagnosis and Treatment
- Marine animal studies overview
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Bioinformatics and Genomic Networks
- Intensive Care Unit Cognitive Disorders
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Healthcare professionals’ stress and burnout
- Burn Injury Management and Outcomes
- Ultrasound in Clinical Applications
- Injury Epidemiology and Prevention
- Healthcare Technology and Patient Monitoring
- COVID-19 and healthcare impacts
University of New Mexico
2023-2025
University of New Mexico Hospital
2025
National Heart Lung and Blood Institute
2023-2024
The University of Texas Health Science Center at Houston
2020-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2024
The University of Texas Southwestern Medical Center
2009-2023
University of California, Los Angeles
2023
Texas Medical Center
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
University of California, San Francisco
2023
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated AD. Recently, several rare variants identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin C (UNC5C) that affect risk for Despite the many successes, architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance...
Abstract Background Most research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants focuses initial symptomatology with limited longer-term data. We characterized prevalences of prolonged symptoms 3 months post–SARS-CoV-2 infection across variant time-periods (pre-Delta, Delta, and Omicron). Methods This multicenter prospective cohort study adults illness tested for SARS-CoV-2 compared fatigue severity, symptoms, organ system–based ≥3 among participants a positive...
<h3>Abstract</h3> <h3>Background:</h3> We evaluated smell identification as a biomarker for Alzheimer disease (AD) by assessing its utility in differentiating normal aging from an amnestic disorder and determining predictive value conversion mild cognitive impairment (aMCI) to AD. <h3>Methods:</h3> Cross-sectional study (AD = 262, aMCI 110, controls 194) measuring (University of Pennsylvania Smell Identification Test [UPSIT]) status was performed, well longitudinal analysis participants (n...
<h3>Objective:</h3> To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) the <i>ATP-binding cassette, subfamily A</i> (<i>ABC1</i>), <i>member 7</i> (<i>ABCA7</i>) gene, known risk factor for late-onset AD. <h3>Methods:</h3> Custom capture sequencing was performed on ∼150 kb encompassing <i>ABCA7</i> 40 AA cases and 37 controls carrying allele (rs115550680). Association testing an deletion identified large data sets (discovery n = 1,068;...
To further the understanding of post-COVID conditions, and provide a more nuanced description symptom progression, resolution, emergence, reemergence after SARS-CoV-2 infection or COVID-like illness, analysts examined data from Innovative Support for Patients with Infections Registry (INSPIRE), prospective multicenter cohort study. This report includes analysis on self-reported symptoms collected 1,296 adults illness who were tested using Food Drug Administration-approved polymerase chain...
Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation lipids and other substrates.
Importance Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use. Objective To compare patient-reported outcomes of physical, mental, and social well-being among adults with illness who received a positive vs negative test result for infection. Design, Setting, Participants This cohort study was planned interim analysis an ongoing multicenter prospective longitudinal registry (the...
Background Reports on medium and long-term sequelae of SARS-CoV-2 infections largely lack quantification incidence relative risk. We describe the rationale methods Innovative Support for Patients with Registry (INSPIRE) that combines patient-reported outcomes data from digital health records to understand predictors impacts infection. Methods INSPIRE is a prospective, multicenter, longitudinal study individuals symptoms infection in eight regions across US. Adults are eligible enrollment if...
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with a complex pathophysiology. Type 2 diabetes (T2D) strong risk factor for AD that shares similar abnormal features including metabolic dysregulation and brain pathology such as amyloid and/or Tau deposits. Emerging evidence suggests circulating branched-chain amino acids (BCAAs) are associated T2D. While excess BCAAs shown to be harmful neurons, its connection poorly understood. Here we show individuals have elevated...
The prevalence, incidence, and interrelationships of persistent symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection vary. There are limited data on specific phenotypes symptoms. Using latent class analysis (LCA) modeling, we sought to identify whether COVID-19 were present 3 months 6 post-infection.
Introduction Data on ethnic and racial differences in symptoms health-related impacts following SARS-CoV-2 infection are limited. We aimed to estimate the 3 6 months after first infection. Methods Participants included adults with enrolled a prospective multicenter US study between 12/11/2020 7/4/2022 as primary cohort of interest, well SARS-CoV-2-negative account for non-SARS-CoV-2-infection impacts, who completed enrollment 3-month surveys ( N = 3,161; 2,402 SARS-CoV-2-positive, 759...
Importance Chronic symptoms reported following an infection with SARS-CoV-2, such as cognitive problems, overlap included in the definition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objective To evaluate prevalence ME/CFS-like illness subsequent to acute SARS-CoV-2 infection, changes ME/CFS through 12 months follow-up, and association test results at infection–like index illness. Design, Setting, Participants This prospective, multisite, longitudinal cohort study...
Accurate prehospital identification of patients with acute ischemic stroke (AIS) from large vessel occlusion (LVO) facilitates direct transport to hospitals that perform endovascular thrombectomy. We hypothesize a cut-off score the Cincinnati Prehospital Stroke Scale (CPSS), simple assessment tool currently used by emergency medical services (EMS) providers, can be identify LVO.Consecutively enrolled, confirmed AIS arriving via EMS between August 2012 and April 2014 at high-volume center in...
Long-term symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are a major concern, yet their prevalence is poorly understood.
Abstract Background While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence symptoms across pre-Delta, Delta, Omicron. Methods conducted an analysis Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. determined association...
Although disparities exist in aspirin administration for chest pain and ST elevation myocardial infarctions (STEMI), little is known about community-based prehospital patients. We evaluated using a national database. conducted retrospective analysis of the 2018-2021 NEMSIS database linked to census data, including adult encounters. created two cohorts: dispatch reason identified STEMI on EKG. stratified patients based majority ZIP Code race/ethnicity (>50% White, Black, Hispanic) into...