A5101744209- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Breast Implant and Reconstruction
- Neurological Disease Mechanisms and Treatments
- Cognitive Functions and Memory
- Reconstructive Surgery and Microvascular Techniques
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Health disparities and outcomes
- Neurobiology of Language and Bilingualism
- Computational Drug Discovery Methods
- Intensive Care Unit Cognitive Disorders
- Breast Cancer Treatment Studies
- GDF15 and Related Biomarkers
- Frailty in Older Adults
University of North Texas Health Science Center
2016-2025
University of North Texas
2016-2025
Albert B. Chandler Hospital
2024
Alzheimer’s Disease Neuroimaging Initiative
2023
University of Bristol
2023
Texas College
2022
NIHR Bristol Biomedical Research Centre
2021
Health First
2021
Bristol Regional Medical Center
2021
The University of Texas Health Science Center at San Antonio
2019
CNS Vital Signs (CNSVS) is a computerized neurocognitive test battery that was developed as routine clinical screening instrument. It comprised of seven tests: verbal and visual memory, finger tapping, symbol digit coding, the Stroop Test, shifting attention continuous performance test. Because CNSVS well-known neuropsychological tests, one should expect its psychometric properties to resemble those conventional tests upon which it based. 1069 subjects age 7–90 participated in normative...
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population society as whole. With numbers of people with ADRDs predicted to rise dramatically across world, scientific community can no longer neglect need for research focusing on among underrepresented ethnoracial diverse groups. The Association International Society Advance Research Treatment (ISTAART; alz.org/ISTAART ) comprises number professional interest areas (PIAs), each major area...
Abstract The last decade has seen a substantial increase in research focused on the identification of blood‐based biomarkers that have utility Alzheimer's disease (AD). Blood‐based significant advantages being time‐ and cost‐efficient as well reduced invasiveness increased patient acceptance. Despite these efforts, field been hampered by lack reproducibility an unclear path for moving basic discovery toward clinical utilization. Here we reviewed recent literature AD to provide current state...
Both patients suffering from schizophrenia and recurring mood disorder show cognitive impairments as established by a variety of neuropsychological tests. The aim the present study was to investigate performance euthymic who had possible relationship between episodes hospitalization impairments.Twenty-six with DSM-III-R diagnosis were investigated using Synonym Reasoning Block-Test Battery part Halstead-Reitan Test Battery.An overall lowered in test results found. There significant positive...
<h3>Abstract</h3> <h3>Background:</h3> We evaluated smell identification as a biomarker for Alzheimer disease (AD) by assessing its utility in differentiating normal aging from an amnestic disorder and determining predictive value conversion mild cognitive impairment (aMCI) to AD. <h3>Methods:</h3> Cross-sectional study (AD = 262, aMCI 110, controls 194) measuring (University of Pennsylvania Smell Identification Test [UPSIT]) status was performed, well longitudinal analysis participants (n...
This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care.
Despite the clinical implementation, there remain significant gaps in our knowledge regarding impact of race/ethnicity or common medical comorbidity on plasma Alzheimer's disease (AD) biomarkers.Plasma biomarkers amyloid beta (Aβ)40, Aβ42 , total tau, and neurofilament light chain (NfL) were measured across cognitively normal Mexican Americans (n = 445) non-Hispanic Whites 520).Dyslipidemia was associated with elevated Aβ40 (P .01) .001) while hypertension .003), < .001), tau .002) levels....
Abstract Introduction No large‐scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Methods Baseline data were analyzed among n = 890 Mexican Americans and 813 non‐Hispanic Whites from the multi‐ethnic Health & Aging Brain Latino Elders (HABLE) study. Plasma NfL was measured on Simoa platform. Results In unadjusted models, significantly associated with age ( P < .001), hypertension dyslipidemia .02), diabetes .001). Covarying for sex,...
Objective: To determine the association of symptom burden to work limitation among working survivors malignant brain tumors. Methods: Working adults with tumors (n = 95) and a non-cancer comparison 131) group completed web-based questionnaire. Measures demographics, tumor type treatment, fatigue, emotional distress, cognitive limitations, factors that can positively impact work, including health behaviors problem solving, were obtained. Results: Survivors reported higher levels limitations...
Using the mandibular inferior border of four fox hounds from an extraoral approach, six high-profile Brånemark implants were placed in each animal and bone grafted. Graft materials studied included demineralized freeze-dried allograft with without irradiation sterilization (3.8 x 10(4) Gy), corticocancellous iliac autograft, blood clot, a control. Corticocancellous grafts expanded polytetrafluoroethylene (EPTFE) barriers. The barrier function improved both graft volume incorporated...
The purpose of the study was to provide characterization Mexican Americans who meet criteria for Alzheimer's disease (AD) and mild cognitive impairment (MCI). For study, 1,069 participants ages 40 above self-identified as either non-Hi
Numerous serum and plasma based biomarkers of systemic inflammation have been linked to both neuropsychiatric disorders Alzheimer's disease (AD). The present study investigated the relationship clinical cardiovascular risk (chole
Abstract Background Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines MCI among Mexican Americans. Methods Data from 1628 participants (non‐Hispanic n = 1002; American 626) were analyzed two ongoing studies aging and Alzheimer's disease, Project FRONTIER (Facing Rural Obstacles to health Now Through Intervention, Education & Research) TARCC (Texas Research Care Consortium). Results When looking at the full...
Objectives . To investigate the link between neurocognitive measures and various aspects of daily living (ADL IADL) in women men with mild Alzheimer′s disease (AD). Methods Participants were 202 AD patients (91 male, 111 female) CDR global scores ≤1. ADLs IADLs ratings obtained from caregivers. Cognitive domains assessed neuropsychological testing. Results Memory executive functioning related to IADL scores. Executive was linked total ADL. Comparisons stratified on gender found attention...
This study aimed to provide normative references for Mexican Americans on neuropsychological measures of cognitive functioning. Data were analyzed from a total 797 Mexican-Americans recruited across three Texas-based studies with approximately one-half the participants tested in Spanish. Normative tables include: MMSE, AMNART, WMS-III (Logical Memory I, II; Visual Reproduction Digit Span), CERAD, RAVLT, Exit25, CLOX 1 & 2, Trail Making Test- A&B, BNT, COWA, and Animal Naming. The norms...
Background: There is a need for more reliable diagnostic tools the early detection of Alzheimer’s disease (AD). This can be challenge due to number factors and logistics making machine learning viable option. Objective: In this paper, we present on Support Vector Machine Leave-One-Out Recursive Feature Elimination Cross Validation (SVM-RFE-LOO) algorithm use in AD show how SVM-RFE-LOO method used both classification prediction AD. Methods: Data were analyzed n = 300 participants ( 150 AD;...
Background Due to their low cost, less invasive nature, and ready availability, plasma biomarkers of Alzheimer's disease have been proposed as one-time screening tools for clinical trials research. The impact ethnoracial factors on these has received little attention. current cross-sectional study investigated the levels Aβ 40 , 42 total tau (t tau), neurofilament light (NfL) across diagnoses each three major groups in United States a community-based cohort older adults. Methods A 1,862...
<i>Aims:</i> Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through Texas Alzheimer’s Research Consortium cohort. <i>Methods:</i> A total of 399 participants [probable disease (AD) n = 198, controls 201] were available for analysis. The BDNF assayed via multiplex immunoassay. Regression analyses utilized examine relation functioning. <i>Results:</i> There no significant...
Background: The links between diabetes, depression, and Alzheimer's disease (AD) has been established, but they are still poorly understood. However, little research examined the effect that comorbidity of depression diabetes on cognitive impairment in an ethnically diverse sample. Ob jective: purpose this study was to investigate relationship comorbid dysfunction; examine population. Methods Results: Analyses data from 2,436 participants (914 men 1,522 women) three separate cohorts: HABLE,...
Mucositis is an inflammatory process that can involve the mucosal epithelial cells from mouth to rectum. Historically, mucositis and stomatitis were used interchangeably, but momentum has increased toward more specific terminology since 2000s. Stomatitis refers diseases of mouth, including mucosa, dentition, periapices, periodontium, whereas globally involving mucous membranes oral cavity gastrointestinal tract. In addition, differentiation needed regarding remainder tract require use a...
Background: The aim of this study is to evaluate the link between C-reactive protein (CRP) and Alzheimer's disease (AD) mild cognitive impairment (MCI) among Mexican Americans. Methods: Non-fasting serum CRP levels, Mini-Mental State Examination
Background: To date, the therapeutic paradigm for Alzheimer’s disease (AD) has focused on a single intervention all patients. However, large literature in oncology supports benefits of precision medicine approach to therapy. Here we test precision-medicine AD Objective: determine if baseline, blood-based proteomic companion diagnostic predicts response NSAID Methods: Proteomic assays plasma from multicenter, randomized, double-blind, placebo-controlled, parallel group trial, with 1-year...