A5063379362- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Dental Implant Techniques and Outcomes
- Escherichia coli research studies
- Child Nutrition and Water Access
- Dermatological diseases and infestations
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Periodontal Regeneration and Treatments
- Entomological Studies and Ecology
- Clostridium difficile and Clostridium perfringens research
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Aquaculture disease management and microbiota
- Digestive system and related health
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Nasal Surgery and Airway Studies
- Dental Anxiety and Anesthesia Techniques
- Reading and Literacy Development
- Probiotics and Fermented Foods
University of Utah
2016-2024
University of Colorado Anschutz Medical Campus
2017-2024
Johns Hopkins University
2019-2023
University of Florida
2023
University of Haiti
2023
University of Colorado Denver
1996-2020
University of Utah Hospital
2019
Massachusetts General Hospital
2019
Denver Health Medical Center
2017
University of Pennsylvania
2015
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits by constraining the nlrp3 inflammasome. was increased in biopsies from patients with active IBD and preclinical models of inflammation. miR-223-/y mice presented exacerbated myeloid-driven experimental colitis heightened clinical, histopathological,...
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that aid in protection against bacterial pathogens at mucosal surfaces through the release of inflammatory cytokines and cytotoxic molecules. Recent evidence suggests MAIT can also provide B cell help. In this study, we describe a population CXCR5+ follicular helper (Tfh)–like (MAITfh) have capacity to help within lymphoid organs. MAITfh preferentially located near germinal centers human tonsils express classical...
Using the mandibular inferior border of four fox hounds from an extraoral approach, six high-profile Brånemark implants were placed in each animal and bone grafted. Graft materials studied included demineralized freeze-dried allograft with without irradiation sterilization (3.8 x 10(4) Gy), corticocancellous iliac autograft, blood clot, a control. Corticocancellous grafts expanded polytetrafluoroethylene (EPTFE) barriers. The barrier function improved both graft volume incorporated...
Clostridium difficile is a Gram-positive spore-forming pathogen and leading cause of nosocomial diarrhea. C. infections are transmitted when ingested spores germinate in the gastrointestinal tract transform into vegetative cells. Germination begins germinant receptor CspC detects bile salts gut. subtilisin-like serine pseudoprotease that activates related CspB protease through an unknown mechanism. Activated cleaves pro-SleC zymogen, which allows activated SleC cortex hydrolase to degrade...
Sporulation is an ancient developmental process that involves the formation of a highly resistant endospore within larger mother cell. In model organism Bacillus subtilis, sporulation-specific sigma factors activate compartment-specific transcriptional programs drive spore morphogenesis. σG activity in forespore depends on secretion complex, known as "feeding tube," bridges cell and maintains integrity. Even though these channel components are conserved all formers, recent studies major...
ABSTRACT Zinc is an essential trace metal required for numerous cellular processes in all forms of life. In order to maintain zinc homeostasis, bacteria have developed several transport systems regulate its uptake. this study, we investigated the enteric pathogen Vibrio cholerae , causative agent cholera. Bioinformatic analysis predicts that two gene clusters, VC2081 VC2083 (annotated as utilization genes znuABC ) and VC2551 VC2555 z inc- r egulated g enes zrgABCDE ), are regulated by...
Abstract Background The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria and maintaining intestinal homeostasis in health disease. Some MGL defects allowing directly contact colonic surface are commonly observed ulcerative colitis (UC). major macromolecular component secreted gel-forming mucin MUC2, whose expression essential for health. In UC, another mucin, MUC5AC, induced. mice, Muc5ac protective during helminth infection. Here we tested functional role...
Sepsis is a systemic inflammatory response to infection and leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like enriched in mucosal tissues that recognize bacterial ligands. We investigated MAIT during clinical experimental sepsis, their contribution host responses. In MAIT-deficient mice had significantly increased mortality load, reduced tissue-specific cytokine WT expressed lower levels IFN-γ IL-17a sepsis compared sham surgery, changes not seen non-MAIT...
Mucosal-associated invariant T (MAIT) cells are unconventional lymphocytes with a semi-conserved TCRα, activated by the presentation of vitamin B metabolites MHC-I related protein, MR1, and diverse innate adaptive effector functions. The role MAIT in acute intestinal infections, especially at mucosal level, is not well known. Here, we analyzed presence phenotype duodenal biopsies paired peripheral blood samples, patients during after culture-confirmed Vibrio cholerae O1 infection....
454 patients were treated with quassia tincture for head lice. At examination one week later only three had hatched There was firm evidence that these been reinfested. The treatment procedure acceptable both to and staff no side-effects observed. As resistance clophenothane has appeared, alternative cures are needed. This study confirms earlier reports on the effectiveness of tincture, which seems be a useful clophenothane. present recommended is two applications an interval week.
Mucosal-associated invariant T (MAIT) cells are innate-like enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vaccine responses to bacterial pathogens such
112 patients with head lice were treated a shampoo containing pyrethrins. All twice an interval of one week. At examination immediately before the second treatment, 6 had small, newly hatched lice, and patient both small mature lice--probably due to reinfestation. This was lice-free after third other treatment. It is concluded that pyrethrins are highly effective against have advantages low toxicity mammals short contact time.
Pneumonia and diarrhea are among the leading causes of death worldwide, epidemiological studies have demonstrated that is associated with an increased risk subsequent pneumonia. Our aim was to determine impact intestinal infection on innate immune responses in lung. Using a mouse model by Salmonella enterica serovar Typhimurium (S. [ST]), we investigated associations between gastrointestinal infections lung bacterial (Klebsiella pneumoniae) challenge. We found alterations frequencies cells...
Abstract is not available.
Mucosal-associated invariant T (MAIT) cells are innate-like that can be activated by microbial antigens and cytokines abundant in mucosal tissues including the colon. MAIT have cytotoxic pro-inflammatory functions potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, role colon cancer, limited. Using an animal model of we show peritumoral injection vivo-expanded RAG1-/- mice with MC38-derived tumors inhibits tumor growth compared to control. Multiplex...
Abstract Mucosal‐associated invariant T (MAIT) cells are innate‐like that can be activated by microbial antigens and cytokines abundant in mucosal tissues including the colon. MAIT have cytotoxic pro‐inflammatory functions potentials for use as adoptive cell therapy. However, studies into their anti‐cancer activity, role colon cancer, limited. Using an animal model of we showed peritumoral injection vivo ‐ expanded RAG1 −/− mice with MC38‐derived tumours inhibits tumour growth compared to...