A5101584709- Heart Failure Treatment and Management
- Healthcare Policy and Management
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and Mental Health
- Primary Care and Health Outcomes
- Tuberculosis Research and Epidemiology
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Suicide and Self-Harm Studies
- Influenza Virus Research Studies
- Blood Pressure and Hypertension Studies
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Disaster Response and Management
- Chronic Disease Management Strategies
- Cardiac Imaging and Diagnostics
Yale New Haven Hospital
2016-2025
Yale University
2012-2024
Yale New Haven Health System
2014-2024
Center for Outcomes Research and Clinical Epidemiology
2024
Harvard University Press
2023
University of British Columbia
2023
Brigham and Women's Hospital
2023
Inspire Institute
2022
Hulunbuir University
2022
University of Alberta
2019
The COVID-19 pandemic has disproportionately affected Hispanic or Latino, non-Hispanic Black (Black), American Indian Alaska Native (AI/AN), and Hawaiian Other Pacific Islander (NH/PI) populations in the United States. These have experienced higher rates of infection mortality compared with White (White) population (1-5) greater excess (i.e., percentage increase number persons who died relative to expected deaths for a given place time) (6). A limitation existing research on among...
This study uses national death certificate data to characterize trends in and excess mortality from drug overdoses, homicides, unintentional injuries, motor vehicle crashes, suicide during the first 6 months of pandemic US.
The current acute kidney injury (AKI) risk prediction model for patients undergoing percutaneous coronary intervention (PCI) from the American College of Cardiology (ACC) National Cardiovascular Data Registry (NCDR) employed regression techniques. This study aimed to evaluate whether models using machine learning techniques could significantly improve AKI after PCI.We used same cohort and candidate variables develop NCDR CathPCI model, including 947,091 who underwent PCI procedures between...
Background— Despite increasing attention on reducing relatively costly hospital practices while maintaining the quality of care, few studies have examined how hospitals use intensive care unit (ICU), a high-cost setting, for patients admitted with heart failure (HF). We characterized patterns ICU admission HF and determined their association ICU-level therapies patient outcomes. Methods Results— identified 166 224 discharges from 341 in 2009–2010 Premier Perspective database. excluded <25...
IMPORTANCE Current guidelines allow substantial discretion in use of noninvasive cardiac imaging for patients without acute myocardial infarction (AMI) who are being evaluated ischemia. Imaging may affect downstream testing and outcomes. OBJECTIVE To characterize hospital variation the association with testing, interventions, DESIGN, SETTING, AND PARTICIPANTS Cross-sectional study hospitals using 2010 administrative data from Premier, Inc, including suspected ischemia on initial evaluation...
The Centers for Medicare & Medicaid Services publicly reports risk-standardized mortality rates (RSMRs) within 30-days of admission and, in 2013, unplanned readmission (RSRRs) discharge patients hospitalized with acute myocardial infarction (AMI), heart failure (HF), and pneumonia. Current reported data do not focus on variation national results or annual changes.Describe U.S. hospital performance AMI, HF, pneumonia updated measures to provide perspective variation.To identify recent changes...
Mortality From Drug Overdose, Homicide, Unintentional Injuries, Motor Vehicle Crashes, and Suicide During the COVID-19 Pandemic
<h3>Importance</h3> An increasing proportion of people in the US hospitalized for acute myocardial infarction (AMI) are younger than 55 years, with largest increase young women. Effective prevention requires an understanding risk factors associated AMI women compared men. <h3>Objectives</h3> To assess sex-specific associations demographic, clinical, and psychosocial first among adults overall, by subtype. <h3>Design, Setting, Participants</h3> This study used a case-control design 2264...
New methods such as machine learning techniques have been increasingly used to enhance the performance of risk predictions for clinical decision-making. However, commonly reported metrics may not be sufficient capture advantages these newly proposed models their adoption by health care professionals improve care. Machine often estimation certain subpopulations that missed metrics.This article addresses limitations comparison and proposes additional metrics. Our discussions cover related...
Importance Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use. Objective To compare patient-reported outcomes of physical, mental, and social well-being among adults with illness who received a positive vs negative test result for infection. Design, Setting, Participants This cohort study was planned interim analysis an ongoing multicenter prospective longitudinal registry (the...
Long-term symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are a major concern, yet their prevalence is poorly understood.
Abstract Background While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence symptoms across pre-Delta, Delta, Omicron. Methods conducted an analysis Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. determined association...
Heart failure as recognized and treated in typical practice may represent a complex condition that defies discrete categorizations. To illuminate this complexity, we examined treatment strategies for patients hospitalized decompensated heart failure. We focused on the receipt of medications appropriate other acute conditions associated with shortness breath including asthma, pneumonia, exacerbated chronic obstructive pulmonary disease.
Objectives To determine how often hospitalized older adults principally diagnosed with pneumonia, chronic obstructive pulmonary disease ( COPD ), or heart failure HF ) are concurrently treated for two more of these acute cardiopulmonary conditions. Design Retrospective cohort study. Setting 368 U.S. hospitals in the Premier research database. Participants Individuals aged 65 and , 2009 2010. Measurements Proportion episodes conditions during first 2 hospital days. Results Of 91,709 pneumonia...
Determining the association of contrast volume during percutaneous coronary intervention (PCI) with risk acute kidney injury (AKI) is important for optimizing PCI safety.To quantify how AKI associated volume, accounting possibility nonlinearity and heterogeneity among different baseline risks.This prognostic study used data from American College Cardiology National Cardiovascular Data Registry CathPCI 1694 US hospitals. Derivation analysis included 2 076 694 individuals who underwent July 1,...
We evaluated the immunogenicity and protective efficacy of a combined DNA vaccine containing six genes encoding immunodominant antigens from Mycobacterium bovis Brucella abortus. The number lymph node spleen cultures positive for M. B. abortus calves immunized with was significantly reduced (p < 0.01) compared unvaccinated after challenge virulent 544. group displayed stronger antigen-specific interferon-γ (IFN-γ) responses IFN-γ ELISPOT activities 2 months final immunization challenge....
Risk adjustment models using claims-based data are central in evaluating health care performance. Although US Centers for Medicare & Medicaid Services (CMS) apply well-vetted statistical approaches, recent changes the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coding system and advances computational capabilities may provide an opportunity enhancement.To examine whether already available would enhance risk yield greater discrimination...