A5068803228- Global Public Health Policies and Epidemiology
- Health Promotion and Cardiovascular Prevention
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Chronic Disease Management Strategies
- Lipoproteins and Cardiovascular Health
- Genetic Mapping and Diversity in Plants and Animals
- COVID-19 Clinical Research Studies
- Estrogen and related hormone effects
- Genetics and Neurodevelopmental Disorders
- Pharmaceutical Economics and Policy
- Potassium and Related Disorders
- Smoking Behavior and Cessation
- Long-Term Effects of COVID-19
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Metastasis and carcinoma case studies
- Cardiovascular Health and Risk Factors
- Synthesis of β-Lactam Compounds
- Cardiac electrophysiology and arrhythmias
Pfizer (United States)
2014-2025
Portuguese Army
2014
Mayo Clinic
2006
Columbia University
1998-2002
Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (Mpro) inhibitor with potent pan–human-coronavirus activity in vitro.
SummaryMaximum-likelihood analysis (via LOD score) provides the most powerful method for finding linkage when mode of inheritance (MOI) is known. However, because one must assume an MOI, application LOD-score to complex disease has been questioned. Although it known that can legitimately maximize maximum score with respect genetic parameters, this approach raises three concerns: (1) multiple testing, (2) effect on power detect linkage, and (3) adequacy approximate MOI true MOI. We evaluated...
Background Increased urbanization in the developing world parallels a rising burden of chronic diseases. Developing countries account for ∼80% global cardiovascular (CV) deaths, but contribute paucity systematic epidemiological data on CV risk factors. Objective To estimate prevalence factors rural and urban cohorts attending general practice clinics Africa Middle East (AfME) region. Methods In cross-sectional study, presence (hypertension, diabetes mellitus (diabetes), dyslipidemia,...
Limited data exist on the epidemiology of cardiovascular risk factors in Saudi Arabia, particularly relation to differences between nationals and expatriates Arabia. The aim this analysis was describe current prevalence among patients attending general practice clinics across Arabia.In cross-sectional epidemiological Africa Middle East Cardiovascular Epidemiological (ACE) study, (hypertension, diabetes, dyslipidemia, obesity, smoking, abdominal obesity) evaluated adults primary care Group...
Abstract Introduction In contrast to nonsteroidal aromatase inhibitors, the steroidal inactivator exemestane does not have detrimental effects on bone in animal models. This study was designed compare of with inhibitors anastrozole and letrozole serum urine levels biomarkers turnover healthy postmenopausal women. Methods Changes concentrations bone-turnover markers, estrogens, lipids were assessed after daily administration (25 mg), (2.5 (1 or placebo for 24 weeks The primary end point...
Sildenafil, approved for pulmonary arterial hypertension (PAH), has a recommended adult dose of 20 mg TID, with previously 5-mg TID by the US Food and Drug Administration. Safety concerns arose because common off-label use higher doses, particularly after pediatric data linked doses to increased mortality. To assess this, Administration mandated study evaluating effects various sildenafil on mortality in adults PAH.
Abstract Previous work using two‐point linkage analysis showed that performing a lod score (LOD) twice, once assuming dominant and recessive inheritance, then taking the larger of two values (designated MMLS) usually has more power to detect than any other method tested. Using computer simulation for variety complex inheritance models, we demonstrated MMLS comparable with true model. However, reports in literature suggested approach might fail multipoint due genetic model misspecification....
SummarySeveral loci and candidate genes for epilepsies or epileptic syndromes map have been suggested to chromosome 8. We investigated families with adolescent-onset idiopathic generalized epilepsy (IGE), linkage markers spanning The IGEs that we studied included juvenile myoclonic (JME), only tonic-clonic seizures occurring either randomly during the day (random grand mal) on awakening (awakening mal), absence (JAE). looked a gene common all these IGEs, but also specific subforms of IGE....
A significant number of cardiovascular disease (CVD)-related deaths occur in developing countries. An increasing prevalence CVD is associated with a change the macro-economy these In this post hoc analysis, risk factor (CVDRF) evaluated across countries based on national income Africa and Middle East Region (AfME).Data from Cardiovascular Epidemiological (ACE) study were used; cross-sectional 14 AfME (94 clinics) July 2011-April 2012, which CVDRF stable adult outpatients. World Bank...
Abstract Locus heterogeneity is a major confounding factor in linkage analysis. When no prior knowledge of exists, and one aims to detect simultaneously, classical distribution theory log‐likelihood ratios does not hold. Despite some theoretical work on this problem, generally accepted practical guidelines exist. Nor has anyone rigorously examined the combined effect testing for simultaneously maximizing over two genetic models (dominant, recessive). The phase represents another...
3520 Background: This report examines UGT1A1*28, toxicity, and outcome in trial NCCTG N9741 patients (pts) receiving combination chemotherapy for advanced colorectal cancer. Methods: Blood samples were collected from 520 pts randomized between 2/18/00 7/18/02. Pts treated with irinotecan/5-fluorouracil (5FU)/leucovorin (LV) (IFL, n=114), oxaliplatin/5FU/LV (FOLFOX, n=299), irinotecan/oxaliplatin (IROX, n=107). 19% of IFL received full-dose (125 mg/m 2 ) irinotecan; the rest a reduced dose...
In patients with active cancer and acute venous thromboembolism (VTE), the low-molecular-weight-heparin (LMWH) dalteparin is more effective than vitamin K antagonist (VKA) in reducing risk of recurrent (rVTE) without increasing bleeding. However, relative benefit LMWH versus VKA at high or low rVTE bleeding unclear. This post hoc analysis used data from CLOT study to explore efficacy safety preventing thrombosis high- low-risk cancer. High-risk were defined by metastatic disease and/or...
Background: Visit-to-visit office blood pressure (BP) variability (BPV) has been associated with morbidity and mortality outcomes in several cardiovascular conditions. The aim of this study was to evaluate the association between BPV patients heart failure reduced ejection fraction effect eplerenone on BPV. Methods results: We evaluated associations BPV, calculated as SBP coefficient variation (SBP-CoV = SD/mean × 100%), primary composite endpoint or hospitalization (HFH), its components,...
Incidence and mortality of candidaemia/invasive candidiasis (C/IC) is relatively high in Latin America versus North Europe. To assess efficacy safety intravenous (IV) anidulafungin American adults with documented C/IC. All patients this open-label study received initial IV optional step-down to oral voriconazole after 5 days; total treatment duration was 14-42 days. The primary endpoint global response (clinical + microbiological response) at end (EOT); missing/indeterminate responses were...
With globalization and rapid urbanization, demographic epidemiologic transitions have become important determinants for the emergence of cardiovascular disease (CVD).To estimate prevalence CVD risk factors in adult out-patients attending general practice non-specialist clinics urban rural Nigeria.As part Africa Middle East Cardiovascular Epidemiological (ACE) study, a cross-sectional study was undertaken presence hypertension, diabetes mellitus, dyslipidemia, obesity, smoking abdominal...
Limited data exit on the epidemiology of cardiovascular risk factors in Saudi Arabia particularly relation to differences between local citizens and expatriates. The aim this analysis is describe current prevalence among patients attending general practice clinics Arabia. In a cross- sectional epidemiological study, presence (hypertension, diabetes, dyslipidaemia, obesity, smoking, abdominal obesity) was evaluated stable adult outpatients primary care Groups comparison were made A total 550...
<p><strong>Background: </strong><span style="font-family: Calibri;">T</span>he Africa Middle East (AfME) Cardiovascular Epidemiological (ACE) study demonstrated that cardiovascular risk factors are highly prevalent among relatively young adult outpatients attending general practice clinics across AfME regions.</p><p><strong>Objective: </strong>Based on the broader estimates from ACE Study, this sub-analysis evaluated prevalence of in...